Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2
Identifieur interne : 000997 ( Pmc/Checkpoint ); précédent : 000996; suivant : 000998Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2
Auteurs : Adam B. Goldring [États-Unis] ; Dylan F. Cooke [États-Unis] ; Mary K. L. Baldwin [États-Unis] ; Gregg H. Recanzone [États-Unis] ; Adam G. Gordon [États-Unis] ; Tingrui Pan [États-Unis] ; Scott I. Simon [États-Unis] ; Leah Krubitzer [États-Unis]Source :
- Journal of Neurophysiology [ 0022-3077 ] ; 2014.
Abstract
The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (
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DOI: 10.1152/jn.00141.2014
PubMed: 25143537
PubMed Central: 4233279
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Goldring</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. 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Baldwin</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. 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Gordon</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. 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II. Alterations in response properties of neurons in areas 1 and 2</title><author><name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. Cooke</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Baldwin, Mary K L" sort="Baldwin, Mary K L" uniqKey="Baldwin M" first="Mary K. L." last="Baldwin">Mary K. L. Baldwin</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Neurobiology, Physiology, and Behavior, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Gordon, Adam G" sort="Gordon, Adam G" uniqKey="Gordon A" first="Adam G." last="Gordon">Adam G. Gordon</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. Simon</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of Neurophysiology</title><idno type="ISSN">0022-3077</idno><idno type="eISSN">1522-1598</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (<italic>Macaca mulatta</italic>) before, during, and after reversible deactivation of areas 5L or 7b or motor cortex (M1/PM), while select locations on the hand and forelimb were stimulated. Response changes were quantified as increases and decreases to stimulus-driven activity relative to baseline and analyzed during three recording epochs: during deactivation (“cool”) and at two time points after deactivation (“rewarm 1,” “rewarm 2”). Although the type of response change observed was variable, for neurons at the recording sites tested >90% exhibited a significant change in response during cooling of 7b while cooling area 5L or M1/PM produced a change in 75% and 64% of sites, respectively. These results suggest that regions in the PPC, and to a lesser extent motor cortex, shape the response characteristics of neurons in areas 1 and 2 and that this kind of feedback modulation is necessary for normal somatosensory processing. Furthermore, this modulation appears to happen on a minute-by-minute basis and may serve as the substrate for phenomena such as somatosensory attention.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurophysiol</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurophysiol</journal-id><journal-id journal-id-type="hwp">jn</journal-id><journal-id journal-id-type="pmc">jn</journal-id><journal-id journal-id-type="publisher-id">JN</journal-id><journal-title-group><journal-title>Journal of Neurophysiology</journal-title></journal-title-group><issn pub-type="ppub">0022-3077</issn><issn pub-type="epub">1522-1598</issn><publisher><publisher-name>American Physiological Society</publisher-name><publisher-loc>Bethesda, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25143537</article-id><article-id pub-id-type="pmc">4233279</article-id><article-id pub-id-type="publisher-id">JN-00141-2014</article-id><article-id pub-id-type="doi">10.1152/jn.00141.2014</article-id><article-categories><subj-group subj-group-type="heading"><subject>Sensory Processing</subject></subj-group></article-categories><title-group><article-title>Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Goldring</surname><given-names>Adam B.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Cooke</surname><given-names>Dylan F.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Baldwin</surname><given-names>Mary K. L.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Recanzone</surname><given-names>Gregg H.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gordon</surname><given-names>Adam G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Tingrui</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simon</surname><given-names>Scott I.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Krubitzer</surname><given-names>Leah</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><sup>1</sup>Center for Neuroscience, University of California, Davis, California;</aff><aff id="aff2"><sup>2</sup>Department of Psychology, University of California, Davis, California;</aff><aff id="aff3"><sup>3</sup>Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California; and</aff><aff id="aff4"><sup>4</sup>Department of Biomedical Engineering, University of California, Davis, California</aff></contrib-group><author-notes><fn id="fn1" fn-type="equal"><label>*</label><p>A. B. Goldring and D. F. Cooke contributed equally to this work.</p></fn><corresp id="cor1">Address for reprint requests and other correspondence: L. Krubitzer, <addr-line>Center for Neuroscience, 1544 Newton Ct., Davis, CA 95618</addr-line> (e-mail: <email>lakrubitzer@ucdavis.edu</email>).</corresp></author-notes><pub-date pub-type="epub"><day>20</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>112</volume><issue>10</issue><fpage>2545</fpage><lpage>2560</lpage><history><date date-type="received"><day>19</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>14</day><month>8</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 the American Physiological Society</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>American Physiological Society</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z9k02214002545.pdf"></self-uri><abstract><p>The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (<italic>Macaca mulatta</italic>) before, during, and after reversible deactivation of areas 5L or 7b or motor cortex (M1/PM), while select locations on the hand and forelimb were stimulated. Response changes were quantified as increases and decreases to stimulus-driven activity relative to baseline and analyzed during three recording epochs: during deactivation (“cool”) and at two time points after deactivation (“rewarm 1,” “rewarm 2”). Although the type of response change observed was variable, for neurons at the recording sites tested >90% exhibited a significant change in response during cooling of 7b while cooling area 5L or M1/PM produced a change in 75% and 64% of sites, respectively. These results suggest that regions in the PPC, and to a lesser extent motor cortex, shape the response characteristics of neurons in areas 1 and 2 and that this kind of feedback modulation is necessary for normal somatosensory processing. Furthermore, this modulation appears to happen on a minute-by-minute basis and may serve as the substrate for phenomena such as somatosensory attention.</p></abstract><kwd-group><kwd>posterior parietal cortex</kwd><kwd>premotor cortex</kwd><kwd>motor cortex</kwd><kwd>cortical deactivation</kwd><kwd>feedback modulation</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name></region><name sortKey="Baldwin, Mary K L" sort="Baldwin, Mary K L" uniqKey="Baldwin M" first="Mary K. L." last="Baldwin">Mary K. L. Baldwin</name><name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. Cooke</name><name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. Cooke</name><name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name><name sortKey="Gordon, Adam G" sort="Gordon, Adam G" uniqKey="Gordon A" first="Adam G." last="Gordon">Adam G. Gordon</name><name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name><name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name><name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name><name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name><name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name><name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. Simon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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