An integrated approach to patient-specific predictive modeling for single ventricle heart palliation
Identifieur interne : 002451 ( Ncbi/Curation ); précédent : 002450; suivant : 002452An integrated approach to patient-specific predictive modeling for single ventricle heart palliation
Auteurs : Chiara Corsini [Italie] ; Catriona Baker [Royaume-Uni] ; Ethan Kung [États-Unis] ; Silvia Schievano [Royaume-Uni] ; Gregory Arbia [France] ; Alessia Baretta [Italie] ; Giovanni Biglino [Royaume-Uni] ; Francesco Migliavacca [Italie] ; Gabriele Dubini [Italie] ; Giancarlo Pennati [Italie] ; Alison Marsden [États-Unis] ; Irene Vignon-Clementel [France] ; Andrew Taylor [Royaume-Uni] ; Tain-Yen Hsia [Royaume-Uni] ; Adam Dorfman [États-Unis]Source :
- Computer methods in biomechanics and biomedical engineering [ 1025-5842 ] ; 2013.
Abstract
In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling.
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DOI: 10.1080/10255842.2012.758254
PubMed: 23343002
PubMed Central: 4242799
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France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea><wicri:noRegion>Le Chesnay</wicri:noRegion><wicri:noRegion>Le Chesnay</wicri:noRegion></affiliation></author><author><name sortKey="Baretta, Alessia" sort="Baretta, Alessia" uniqKey="Baretta A" first="Alessia" last="Baretta">Alessia Baretta</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Biglino, Giovanni" sort="Biglino, Giovanni" uniqKey="Biglino G" first="Giovanni" last="Biglino">Giovanni Biglino</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Marsden, Alison" sort="Marsden, Alison" uniqKey="Marsden A" first="Alison" last="Marsden">Alison Marsden</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vignon Clementel, Irene" sort="Vignon Clementel, Irene" uniqKey="Vignon Clementel I" first="Irene" last="Vignon-Clementel">Irene Vignon-Clementel</name><affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea><wicri:noRegion>Le Chesnay</wicri:noRegion><wicri:noRegion>Le Chesnay</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dorfman, Adam" sort="Dorfman, Adam" uniqKey="Dorfman A" first="Adam" last="Dorfman">Adam Dorfman</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23343002</idno><idno type="pmc">4242799</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242799</idno><idno type="RBID">PMC:4242799</idno><idno type="doi">10.1080/10255842.2012.758254</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001B34</idno><idno 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Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Baker, Catriona" sort="Baker, Catriona" uniqKey="Baker C" first="Catriona" last="Baker">Catriona Baker</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kung, Ethan" sort="Kung, Ethan" uniqKey="Kung E" first="Ethan" last="Kung">Ethan Kung</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schievano, Silvia" sort="Schievano, Silvia" uniqKey="Schievano S" first="Silvia" last="Schievano">Silvia Schievano</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Arbia, Gregory" sort="Arbia, Gregory" uniqKey="Arbia G" first="Gregory" last="Arbia">Gregory Arbia</name><affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea><wicri:noRegion>Le Chesnay</wicri:noRegion><wicri:noRegion>Le Chesnay</wicri:noRegion></affiliation></author><author><name sortKey="Baretta, Alessia" sort="Baretta, Alessia" uniqKey="Baretta A" first="Alessia" last="Baretta">Alessia Baretta</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Biglino, Giovanni" sort="Biglino, Giovanni" uniqKey="Biglino G" first="Giovanni" last="Biglino">Giovanni Biglino</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Marsden, Alison" sort="Marsden, Alison" uniqKey="Marsden A" first="Alison" last="Marsden">Alison Marsden</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vignon Clementel, Irene" sort="Vignon Clementel, Irene" uniqKey="Vignon Clementel I" first="Irene" last="Vignon-Clementel">Irene Vignon-Clementel</name><affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea><wicri:noRegion>Le Chesnay</wicri:noRegion><wicri:noRegion>Le Chesnay</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name><affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dorfman, Adam" sort="Dorfman, Adam" uniqKey="Dorfman A" first="Adam" last="Dorfman">Adam Dorfman</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><series><title level="j">Computer methods in biomechanics and biomedical engineering</title><idno type="ISSN">1025-5842</idno><idno type="eISSN">1476-8259</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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