An integrated approach to patient-specific predictive modeling for single ventricle heart palliation
Identifieur interne : 001411 ( Pmc/Checkpoint ); précédent : 001410; suivant : 001412An integrated approach to patient-specific predictive modeling for single ventricle heart palliation
Auteurs : Chiara Corsini [Italie] ; Catriona Baker [Royaume-Uni] ; Ethan Kung [États-Unis] ; Silvia Schievano [Royaume-Uni] ; Gregory Arbia [France] ; Alessia Baretta [Italie] ; Giovanni Biglino [Royaume-Uni] ; Francesco Migliavacca [Italie] ; Gabriele Dubini [Italie] ; Giancarlo Pennati [Italie] ; Alison Marsden [États-Unis] ; Irene Vignon-Clementel [France] ; Andrew Taylor [Royaume-Uni] ; Tain-Yen Hsia [Royaume-Uni] ; Adam Dorfman [États-Unis]Source :
- Computer methods in biomechanics and biomedical engineering [ 1025-5842 ] ; 2013.
Abstract
In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling.
Url:
DOI: 10.1080/10255842.2012.758254
PubMed: 23343002
PubMed Central: 4242799
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4242799Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An integrated approach to patient-specific predictive modeling for single ventricle heart palliation</title>
<author><name sortKey="Corsini, Chiara" sort="Corsini, Chiara" uniqKey="Corsini C" first="Chiara" last="Corsini">Chiara Corsini</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Catriona" sort="Baker, Catriona" uniqKey="Baker C" first="Catriona" last="Baker">Catriona Baker</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kung, Ethan" sort="Kung, Ethan" uniqKey="Kung E" first="Ethan" last="Kung">Ethan Kung</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schievano, Silvia" sort="Schievano, Silvia" uniqKey="Schievano S" first="Silvia" last="Schievano">Silvia Schievano</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arbia, Gregory" sort="Arbia, Gregory" uniqKey="Arbia G" first="Gregory" last="Arbia">Gregory Arbia</name>
<affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baretta, Alessia" sort="Baretta, Alessia" uniqKey="Baretta A" first="Alessia" last="Baretta">Alessia Baretta</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biglino, Giovanni" sort="Biglino, Giovanni" uniqKey="Biglino G" first="Giovanni" last="Biglino">Giovanni Biglino</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marsden, Alison" sort="Marsden, Alison" uniqKey="Marsden A" first="Alison" last="Marsden">Alison Marsden</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vignon Clementel, Irene" sort="Vignon Clementel, Irene" uniqKey="Vignon Clementel I" first="Irene" last="Vignon-Clementel">Irene Vignon-Clementel</name>
<affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dorfman, Adam" sort="Dorfman, Adam" uniqKey="Dorfman A" first="Adam" last="Dorfman">Adam Dorfman</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23343002</idno>
<idno type="pmc">4242799</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242799</idno>
<idno type="RBID">PMC:4242799</idno>
<idno type="doi">10.1080/10255842.2012.758254</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001B34</idno>
<idno type="wicri:Area/Pmc/Curation">001B34</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001411</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An integrated approach to patient-specific predictive modeling for single ventricle heart palliation</title>
<author><name sortKey="Corsini, Chiara" sort="Corsini, Chiara" uniqKey="Corsini C" first="Chiara" last="Corsini">Chiara Corsini</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Catriona" sort="Baker, Catriona" uniqKey="Baker C" first="Catriona" last="Baker">Catriona Baker</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kung, Ethan" sort="Kung, Ethan" uniqKey="Kung E" first="Ethan" last="Kung">Ethan Kung</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schievano, Silvia" sort="Schievano, Silvia" uniqKey="Schievano S" first="Silvia" last="Schievano">Silvia Schievano</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arbia, Gregory" sort="Arbia, Gregory" uniqKey="Arbia G" first="Gregory" last="Arbia">Gregory Arbia</name>
<affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baretta, Alessia" sort="Baretta, Alessia" uniqKey="Baretta A" first="Alessia" last="Baretta">Alessia Baretta</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biglino, Giovanni" sort="Biglino, Giovanni" uniqKey="Biglino G" first="Giovanni" last="Biglino">Giovanni Biglino</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marsden, Alison" sort="Marsden, Alison" uniqKey="Marsden A" first="Alison" last="Marsden">Alison Marsden</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vignon Clementel, Irene" sort="Vignon Clementel, Irene" uniqKey="Vignon Clementel I" first="Irene" last="Vignon-Clementel">Irene Vignon-Clementel</name>
<affiliation wicri:level="1"><nlm:aff id="A4">INRIA Paris-Rocquencourt, Le Chesnay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRIA Paris-Rocquencourt, Le Chesnay</wicri:regionArea>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
<wicri:noRegion>Le Chesnay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dorfman, Adam" sort="Dorfman, Adam" uniqKey="Dorfman A" first="Adam" last="Dorfman">Adam Dorfman</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Computer methods in biomechanics and biomedical engineering</title>
<idno type="ISSN">1025-5842</idno>
<idno type="eISSN">1476-8259</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P3">In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9802899</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22066</journal-id>
<journal-id journal-id-type="nlm-ta">Comput Methods Biomech Biomed Engin</journal-id>
<journal-id journal-id-type="iso-abbrev">Comput Methods Biomech Biomed Engin</journal-id>
<journal-title-group><journal-title>Computer methods in biomechanics and biomedical engineering</journal-title>
</journal-title-group>
<issn pub-type="ppub">1025-5842</issn>
<issn pub-type="epub">1476-8259</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23343002</article-id>
<article-id pub-id-type="pmc">4242799</article-id>
<article-id pub-id-type="doi">10.1080/10255842.2012.758254</article-id>
<article-id pub-id-type="manuscript">NIHMS642680</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>An integrated approach to patient-specific predictive modeling for single ventricle heart palliation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Corsini</surname>
<given-names>Chiara</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="author-notes" rid="FN1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baker</surname>
<given-names>Catriona</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="author-notes" rid="FN1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kung</surname>
<given-names>Ethan</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schievano</surname>
<given-names>Silvia</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arbia</surname>
<given-names>Gregory</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baretta</surname>
<given-names>Alessia</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Biglino</surname>
<given-names>Giovanni</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Migliavacca</surname>
<given-names>Francesco</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dubini</surname>
<given-names>Gabriele</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pennati</surname>
<given-names>Giancarlo</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marsden</surname>
<given-names>Alison</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vignon-Clementel</surname>
<given-names>Irene</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>Andrew</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hsia</surname>
<given-names>Tain-Yen</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dorfman</surname>
<given-names>Adam</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<on-behalf-of>for the Modeling of Congenital Hearts Alliance (MOCHA) Investigators</on-behalf-of>
<xref ref-type="author-notes" rid="FN2">2</xref>
</contrib-group>
<aff id="A1"><label>a</label>
Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milano, Italy</aff>
<aff id="A2"><label>b</label>
Cardiorespiratory Unit, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK</aff>
<aff id="A3"><label>c</label>
Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA</aff>
<aff id="A4"><label>d</label>
INRIA Paris-Rocquencourt, Le Chesnay, France</aff>
<aff id="A5"><label>e</label>
Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA</aff>
<author-notes><title>Notes</title>
<fn id="FN1"><label>1</label>
<p id="P1">Joint first authors.</p>
</fn>
<fn id="FN2"><label>2</label>
<p id="P2">MOCHA investigators: Andrew Taylor, MD, Alessandro Giardini, MD, Sachin Khambadkone, MD, Silvia Schievano, PhD, Marc de Leval, MD, and T.-Y. Hsia, MD (Institute of Cardiovascular Sciences, UCL, London, UK); Edward Bove, MD and Adam Dorfman, MD (University of Michigan, Ann Arbor, MI, USA); G. Hamilton Baker, MD and Anthony Hlavacek (Medical University of South Carolina, Charleston, SC, USA); Francesco Migliavacca, PhD, Giancarlo Pennati, PhD, and Gabriele Dubini, PhD (Politecnico di Milano, Milan, Italy); Alison Marsden, PhD (University of California, San Diego, CA, USA); Jeffrey Feinstein, MD (Stanford University, Stanford, CA, USA); Irene Vignon-Clementel (INRIA, Paris, France); Richard Figliola, PhD and John McGregor, PhD (Clemson University, Clemson, SC, USA)</p>
</fn>
<corresp id="CR1"><label>*</label>
Corresponding author. <email>francesco.migliavacca@polimi.it</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>1</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>24</day>
<month>11</month>
<year>2014</year>
</pub-date>
<volume>17</volume>
<issue>14</issue>
<fpage>1572</fpage>
<lpage>1589</lpage>
<pmc-comment>elocation-id from pubmed: 10.1080/10255842.2012.758254</pmc-comment>
<permissions><copyright-statement>© 2013 Taylor & Francis</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p id="P3">In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling.</p>
</abstract>
<kwd-group><kwd>computational fluid dynamics</kwd>
<kwd>lumped parameter network</kwd>
<kwd>multi-scale model</kwd>
<kwd>congenital heart disease</kwd>
<kwd>virtual surgery</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Californie</li>
<li>Grand Londres</li>
<li>Michigan</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Corsini, Chiara" sort="Corsini, Chiara" uniqKey="Corsini C" first="Chiara" last="Corsini">Chiara Corsini</name>
</noRegion>
<name sortKey="Baretta, Alessia" sort="Baretta, Alessia" uniqKey="Baretta A" first="Alessia" last="Baretta">Alessia Baretta</name>
<name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name>
<name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name>
<name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Baker, Catriona" sort="Baker, Catriona" uniqKey="Baker C" first="Catriona" last="Baker">Catriona Baker</name>
</region>
<name sortKey="Biglino, Giovanni" sort="Biglino, Giovanni" uniqKey="Biglino G" first="Giovanni" last="Biglino">Giovanni Biglino</name>
<name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name>
<name sortKey="Schievano, Silvia" sort="Schievano, Silvia" uniqKey="Schievano S" first="Silvia" last="Schievano">Silvia Schievano</name>
<name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Kung, Ethan" sort="Kung, Ethan" uniqKey="Kung E" first="Ethan" last="Kung">Ethan Kung</name>
</region>
<name sortKey="Dorfman, Adam" sort="Dorfman, Adam" uniqKey="Dorfman A" first="Adam" last="Dorfman">Adam Dorfman</name>
<name sortKey="Marsden, Alison" sort="Marsden, Alison" uniqKey="Marsden A" first="Alison" last="Marsden">Alison Marsden</name>
</country>
<country name="France"><noRegion><name sortKey="Arbia, Gregory" sort="Arbia, Gregory" uniqKey="Arbia G" first="Gregory" last="Arbia">Gregory Arbia</name>
</noRegion>
<name sortKey="Vignon Clementel, Irene" sort="Vignon Clementel, Irene" uniqKey="Vignon Clementel I" first="Irene" last="Vignon-Clementel">Irene Vignon-Clementel</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001411 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001411 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:4242799 |texte= An integrated approach to patient-specific predictive modeling for single ventricle heart palliation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:23343002" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |