Asymmetrical olfactory acuity and neuroleptic treatment in schizophrenia
Identifieur interne : 008700 ( Main/Merge ); précédent : 008699; suivant : 008701Asymmetrical olfactory acuity and neuroleptic treatment in schizophrenia
Auteurs : S. E. Purdon [Canada] ; P. Flor-Henry [Canada]Source :
- Schizophrenia research [ 0920-9964 ] ; 2000.
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Abstract
Uni-rhinal olfactory acuity in schizophrenia was investigated in two experiments. The first assessed the presence of a predicted atypical asymmetry of nostril laterality and the second assessed the effect of antipsychotic treatment on the asymmetry. Although olfactory identification impairment has been well documented in schizophrenia, olfactory acuity has been neglected. This may be an oversight as cerebral structures of the mesial temporal lobe important to olfactory perception have often been implicated in the pathophysiology of schizophrenia and it is thus reasonable to postulate a primary impairment of olfactory acuity in schizophrenia. In addition, unmedicated patients with schizophrenia have exhibited asymmetrical laterality favouring the right over the left hemisphere in studies of visual, haptic, and auditory perception, and the few published prospective treatment studies have suggested a reversal of this asymmetry with first generation neuroleptic treatments. In experiment 1 a generalization of the perceptual asymmetry to olfactory acuity was examined by measurement of n-butanol olfactory thresholds with the Connecticut Chemosensory Perception Exam (CCPE) in an unmedicated sample of 17 patients with schizophrenia and 17 age, gender, and handedness matched normal controls. The patient sample showed an asymmetrical impairment of the left nostril that was not apparent in the normal control sample. In experiment 2, the CCPE was administered to a new sample of 10 patients with schizophrenia before and after neuroleptic treatment. The asymmetry observed in experiment I was replicated, and the relative advantage of the right nostril shifted to a relative advantage of the left nostril over the course of 8 weeks of treatment. Results are discussed in relation to cerebral aspects of schizophrenia and potential implications to cognitive change from treatment.
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Flor-Henry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Alberta Hospital Edmonton, Box 307</s1><s2>Edmonton, Alberta, T5J 2J7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta, T5J 2J7</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0466810</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0466810 INIST</idno><idno type="RBID">Pascal:00-0466810</idno><idno type="wicri:Area/PascalFrancis/Corpus">001459</idno><idno type="wicri:Area/PascalFrancis/Curation">000054</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001239</idno><idno type="wicri:doubleKey">0920-9964:2000:Purdon S:asymmetrical:olfactory:acuity</idno><idno type="wicri:Area/Main/Merge">008700</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Asymmetrical olfactory acuity and neuroleptic treatment in schizophrenia</title><author><name sortKey="Purdon, S E" sort="Purdon, S E" uniqKey="Purdon S" first="S. E." last="Purdon">S. E. Purdon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Alberta Hospital Edmonton, Box 307</s1><s2>Edmonton, Alberta, T5J 2J7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta, T5J 2J7</wicri:noRegion></affiliation></author><author><name sortKey="Flor Henry, P" sort="Flor Henry, P" uniqKey="Flor Henry P" first="P." last="Flor-Henry">P. Flor-Henry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Alberta Hospital Edmonton, Box 307</s1><s2>Edmonton, Alberta, T5J 2J7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta, T5J 2J7</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Schizophrenia research</title><title level="j" type="abbreviated">Schizophr. res.</title><idno type="ISSN">0920-9964</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Schizophrenia research</title><title level="j" type="abbreviated">Schizophr. res.</title><idno type="ISSN">0920-9964</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acuity</term><term>Asymmetry</term><term>Brain (vertebrata)</term><term>Central nervous system</term><term>Chemotherapy</term><term>Clinical investigation</term><term>Comparative study</term><term>Experimental study</term><term>Follow up study</term><term>Hemispheric specialization</term><term>Human</term><term>Laterality</term><term>Neuroleptic</term><term>Olfaction</term><term>Perception</term><term>Psychotropic</term><term>Schizophrenia</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Schizophrénie</term><term>Etude expérimentale</term><term>Acuité</term><term>Olfaction</term><term>Perception</term><term>Spécialisation hémisphérique</term><term>Latéralité</term><term>Asymétrie</term><term>Etude comparative</term><term>Traitement</term><term>Chimiothérapie</term><term>Neuroleptique</term><term>Psychotrope</term><term>Encéphale</term><term>Système nerveux central</term><term>Exploration clinique</term><term>Etude longitudinale</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Uni-rhinal olfactory acuity in schizophrenia was investigated in two experiments. The first assessed the presence of a predicted atypical asymmetry of nostril laterality and the second assessed the effect of antipsychotic treatment on the asymmetry. Although olfactory identification impairment has been well documented in schizophrenia, olfactory acuity has been neglected. This may be an oversight as cerebral structures of the mesial temporal lobe important to olfactory perception have often been implicated in the pathophysiology of schizophrenia and it is thus reasonable to postulate a primary impairment of olfactory acuity in schizophrenia. In addition, unmedicated patients with schizophrenia have exhibited asymmetrical laterality favouring the right over the left hemisphere in studies of visual, haptic, and auditory perception, and the few published prospective treatment studies have suggested a reversal of this asymmetry with first generation neuroleptic treatments. In experiment 1 a generalization of the perceptual asymmetry to olfactory acuity was examined by measurement of n-butanol olfactory thresholds with the Connecticut Chemosensory Perception Exam (CCPE) in an unmedicated sample of 17 patients with schizophrenia and 17 age, gender, and handedness matched normal controls. The patient sample showed an asymmetrical impairment of the left nostril that was not apparent in the normal control sample. In experiment 2, the CCPE was administered to a new sample of 10 patients with schizophrenia before and after neuroleptic treatment. The asymmetry observed in experiment I was replicated, and the relative advantage of the right nostril shifted to a relative advantage of the left nostril over the course of 8 weeks of treatment. Results are discussed in relation to cerebral aspects of schizophrenia and potential implications to cognitive change from treatment.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Purdon, S E" sort="Purdon, S E" uniqKey="Purdon S" first="S. E." last="Purdon">S. E. Purdon</name></noRegion><name sortKey="Flor Henry, P" sort="Flor Henry, P" uniqKey="Flor Henry P" first="P." last="Flor-Henry">P. Flor-Henry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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