In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt
Identifieur interne : 002680 ( Main/Merge ); précédent : 002679; suivant : 002681In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt
Auteurs : Xiao Wei Tan [Singapour] ; Andri Riau [Singapour] ; Zhi Long Shi [Singapour] ; Anna C S. Tan [Singapour] ; Koon Gee Neoh [Singapour] ; Khiam Aik Khor [Singapour] ; Roger W. Beuerman [Singapour] ; Donald Tan [Singapour] ; Jodhbir S. Mehta [Singapour]Source :
- British Journal of Ophthalmology [ 0007-1161 ] ; 2012-09.
Abstract
Aim Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO2) in a simulated in vitro cornea inflammation environment. Methods Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO2. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy. Results There were less cytokines secreted from human corneal fibroblasts seeded on TiO2 substrates as compared with HA. TiO2 was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO2 was more stable than HA after long-term incubation with ATF. Conclusions TiO2 is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. This would reduce resorption rates for KPro surgery.
Url:
- https://api.istex.fr/document/17555A97CEBD6DC260CE6D7CF8DF71BDDF82C538/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432489
DOI: 10.1136/bjophthalmol-2012-301633
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Beuerman</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS SRP Neuroscience and Behavioral Disorders</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Donald" sort="Tan, Donald" uniqKey="Tan D" first="Donald" last="Tan">Donald Tan</name><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Mehta, Jodhbir S" sort="Mehta, Jodhbir S" uniqKey="Mehta J" first="Jodhbir S" last="Mehta">Jodhbir S. Mehta</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Clinical Sciences, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Ophthalmology</title><title level="j" type="abbrev">Br J Ophthalmol</title><idno type="ISSN">0007-1161</idno><idno type="eISSN">1468-2079</idno><imprint><publisher>BMJ Publishing Group Ltd.</publisher><pubPlace>BMA House, Tavistock Square, London, WC1H 9JR</pubPlace><date type="published" when="2012-09">2012-09</date><biblScope unit="volume">96</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1252">1252</biblScope></imprint><idno type="ISSN">0007-1161</idno></series><idno type="istex">17555A97CEBD6DC260CE6D7CF8DF71BDDF82C538</idno><idno type="DOI">10.1136/bjophthalmol-2012-301633</idno><idno type="href">bjophthalmol-96-1252.pdf</idno><idno type="ArticleID">bjophthalmol-2012-301633</idno><idno type="PMID">22802307</idno><idno type="local">bjophthalmol;96/9/1252</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aim Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO2) in a simulated in vitro cornea inflammation environment. Methods Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO2. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy. Results There were less cytokines secreted from human corneal fibroblasts seeded on TiO2 substrates as compared with HA. TiO2 was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO2 was more stable than HA after long-term incubation with ATF. Conclusions TiO2 is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. This would reduce resorption rates for KPro surgery.</div></front></TEI><double doi="10.1136/bjophthalmol-2012-301633"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt</title><author><name sortKey="Tan, Xiao Wei" sort="Tan, Xiao Wei" uniqKey="Tan X" first="Xiao Wei" last="Tan">Xiao Wei Tan</name></author><author><name sortKey="Riau, Andri" sort="Riau, Andri" uniqKey="Riau A" first="Andri" last="Riau">Andri Riau</name></author><author><name sortKey="Shi, Zhi Long" sort="Shi, Zhi Long" uniqKey="Shi Z" first="Zhi Long" last="Shi">Zhi Long Shi</name></author><author><name sortKey="Tan, Anna C S" sort="Tan, Anna C S" uniqKey="Tan A" first="Anna C S" last="Tan">Anna C S. Tan</name></author><author><name sortKey="Neoh, Koon Gee" sort="Neoh, Koon Gee" uniqKey="Neoh K" first="Koon Gee" last="Neoh">Koon Gee Neoh</name></author><author><name sortKey="Khor, Khiam Aik" sort="Khor, Khiam Aik" uniqKey="Khor K" first="Khiam Aik" last="Khor">Khiam Aik Khor</name></author><author><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W" last="Beuerman">Roger W. Beuerman</name></author><author><name sortKey="Tan, Donald" sort="Tan, Donald" uniqKey="Tan D" first="Donald" last="Tan">Donald Tan</name></author><author><name sortKey="Mehta, Jodhbir S" sort="Mehta, Jodhbir S" uniqKey="Mehta J" first="Jodhbir S" last="Mehta">Jodhbir S. Mehta</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:17555A97CEBD6DC260CE6D7CF8DF71BDDF82C538</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1136/bjophthalmol-2012-301633</idno><idno type="url">https://api.istex.fr/document/17555A97CEBD6DC260CE6D7CF8DF71BDDF82C538/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003091</idno><idno type="wicri:Area/Istex/Curation">003091</idno><idno type="wicri:Area/Istex/Checkpoint">000082</idno><idno type="wicri:doubleKey">0007-1161:2012:Tan X:in:vitro:effect</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt</title><author><name sortKey="Tan, Xiao Wei" sort="Tan, Xiao Wei" uniqKey="Tan X" first="Xiao Wei" last="Tan">Xiao Wei Tan</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Riau, Andri" sort="Riau, Andri" uniqKey="Riau A" first="Andri" last="Riau">Andri Riau</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Zhi Long" sort="Shi, Zhi Long" uniqKey="Shi Z" first="Zhi Long" last="Shi">Zhi Long Shi</name><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Tan, Anna C S" sort="Tan, Anna C S" uniqKey="Tan A" first="Anna C S" last="Tan">Anna C S. Tan</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Neoh, Koon Gee" sort="Neoh, Koon Gee" uniqKey="Neoh K" first="Koon Gee" last="Neoh">Koon Gee Neoh</name><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Khor, Khiam Aik" sort="Khor, Khiam Aik" uniqKey="Khor K" first="Khiam Aik" last="Khor">Khiam Aik Khor</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Mechanical and Aerospace Engineering, Nanyang Technological University</wicri:regionArea><wicri:noRegion>Nanyang Technological University</wicri:noRegion></affiliation></author><author><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W" last="Beuerman">Roger W. Beuerman</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS SRP Neuroscience and Behavioral Disorders</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Donald" sort="Tan, Donald" uniqKey="Tan D" first="Donald" last="Tan">Donald Tan</name><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Mehta, Jodhbir S" sort="Mehta, Jodhbir S" uniqKey="Mehta J" first="Jodhbir S" last="Mehta">Jodhbir S. Mehta</name><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Clinical Sciences, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Ophthalmology</title><title level="j" type="abbrev">Br J Ophthalmol</title><idno type="ISSN">0007-1161</idno><idno type="eISSN">1468-2079</idno><imprint><publisher>BMJ Publishing Group Ltd.</publisher><pubPlace>BMA House, Tavistock Square, London, WC1H 9JR</pubPlace><date type="published" when="2012-09">2012-09</date><biblScope unit="volume">96</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1252">1252</biblScope></imprint><idno type="ISSN">0007-1161</idno></series><idno type="istex">17555A97CEBD6DC260CE6D7CF8DF71BDDF82C538</idno><idno type="DOI">10.1136/bjophthalmol-2012-301633</idno><idno type="href">bjophthalmol-96-1252.pdf</idno><idno type="ArticleID">bjophthalmol-2012-301633</idno><idno type="PMID">22802307</idno><idno type="local">bjophthalmol;96/9/1252</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aim Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO2) in a simulated in vitro cornea inflammation environment. Methods Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO2. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy. Results There were less cytokines secreted from human corneal fibroblasts seeded on TiO2 substrates as compared with HA. TiO2 was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO2 was more stable than HA after long-term incubation with ATF. Conclusions TiO2 is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. This would reduce resorption rates for KPro surgery.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt</title><author><name sortKey="Tan, Xiao Wei" sort="Tan, Xiao Wei" uniqKey="Tan X" first="Xiao Wei" last="Tan">Xiao Wei Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Riau, Andri" sort="Riau, Andri" uniqKey="Riau A" first="Andri" last="Riau">Andri Riau</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Zhi Long" sort="Shi, Zhi Long" uniqKey="Shi Z" first="Zhi Long" last="Shi">Zhi Long Shi</name><affiliation wicri:level="4"><nlm:aff id="aff2">School of Chemical and Bimolecular Engineering, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Tan, Anna C S" sort="Tan, Anna C S" uniqKey="Tan A" first="Anna C S" last="Tan">Anna C S. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Neoh, Koon Gee" sort="Neoh, Koon Gee" uniqKey="Neoh K" first="Koon Gee" last="Neoh">Koon Gee Neoh</name><affiliation wicri:level="4"><nlm:aff id="aff2">School of Chemical and Bimolecular Engineering, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Khor, Khiam Aik" sort="Khor, Khiam Aik" uniqKey="Khor K" first="Khiam Aik" last="Khor">Khiam Aik Khor</name><affiliation wicri:level="1"><nlm:aff id="aff4">School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Mechanical and Aerospace Engineering, Nanyang Technological University</wicri:regionArea><wicri:noRegion>Nanyang Technological University</wicri:noRegion></affiliation></author><author><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W" last="Beuerman">Roger W. Beuerman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Duke-NUS SRP Neuroscience and Behavioral Disorders, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS SRP Neuroscience and Behavioral Disorders</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Donald" sort="Tan, Donald" uniqKey="Tan D" first="Donald" last="Tan">Donald Tan</name><affiliation wicri:level="4"><nlm:aff id="aff2">School of Chemical and Bimolecular Engineering, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Mehta, Jodhbir S" sort="Mehta, Jodhbir S" uniqKey="Mehta J" first="Jodhbir S" last="Mehta">Jodhbir S. Mehta</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Clinical Sciences, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22802307</idno><idno type="pmc">3432489</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432489</idno><idno type="RBID">PMC:3432489</idno><idno type="doi">10.1136/bjophthalmol-2012-301633</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001C18</idno><idno type="wicri:Area/Pmc/Curation">001C18</idno><idno type="wicri:Area/Pmc/Checkpoint">001713</idno><idno type="wicri:Area/Ncbi/Merge">002145</idno><idno type="wicri:Area/Ncbi/Curation">002145</idno><idno type="wicri:Area/Ncbi/Checkpoint">002145</idno><idno type="wicri:doubleKey">0007-1161:2012:Tan X:in:vitro:effect</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt</title><author><name sortKey="Tan, Xiao Wei" sort="Tan, Xiao Wei" uniqKey="Tan X" first="Xiao Wei" last="Tan">Xiao Wei Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Riau, Andri" sort="Riau, Andri" uniqKey="Riau A" first="Andri" last="Riau">Andri Riau</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Zhi Long" sort="Shi, Zhi Long" uniqKey="Shi Z" first="Zhi Long" last="Shi">Zhi Long Shi</name><affiliation wicri:level="4"><nlm:aff id="aff2">School of Chemical and Bimolecular Engineering, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Tan, Anna C S" sort="Tan, Anna C S" uniqKey="Tan A" first="Anna C S" last="Tan">Anna C S. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Neoh, Koon Gee" sort="Neoh, Koon Gee" uniqKey="Neoh K" first="Koon Gee" last="Neoh">Koon Gee Neoh</name><affiliation wicri:level="4"><nlm:aff id="aff2">School of Chemical and Bimolecular Engineering, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Khor, Khiam Aik" sort="Khor, Khiam Aik" uniqKey="Khor K" first="Khiam Aik" last="Khor">Khiam Aik Khor</name><affiliation wicri:level="1"><nlm:aff id="aff4">School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Mechanical and Aerospace Engineering, Nanyang Technological University</wicri:regionArea><wicri:noRegion>Nanyang Technological University</wicri:noRegion></affiliation></author><author><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W" last="Beuerman">Roger W. Beuerman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Duke-NUS SRP Neuroscience and Behavioral Disorders, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS SRP Neuroscience and Behavioral Disorders</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Donald" sort="Tan, Donald" uniqKey="Tan D" first="Donald" last="Tan">Donald Tan</name><affiliation wicri:level="4"><nlm:aff id="aff2">School of Chemical and Bimolecular Engineering, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Chemical and Bimolecular Engineering, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Mehta, Jodhbir S" sort="Mehta, Jodhbir S" uniqKey="Mehta J" first="Jodhbir S" last="Mehta">Jodhbir S. Mehta</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute</wicri:regionArea><wicri:noRegion>Singapore Eye Research Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Singapore National Eye Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Centre</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Clinical Sciences, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author></analytic><series><title level="j">The British Journal of Ophthalmology</title><idno type="ISSN">0007-1161</idno><idno type="eISSN">1468-2079</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO<sub>2</sub>) in a simulated in vitro cornea inflammation environment.</p></sec><sec><title>Methods</title><p>Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO<sub>2</sub>. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy.</p></sec><sec><title>Results</title><p>There were less cytokines secreted from human corneal fibroblasts seeded on TiO<sub>2</sub> substrates as compared with HA. TiO<sub>2</sub> was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO<sub>2</sub> was more stable than HA after long-term incubation with ATF.</p></sec><sec><title>Conclusions</title><p>TiO<sub>2</sub> is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. 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