Normalization of nutritional status by various levels of vitamin E supplementation during murine AIDS
Identifieur interne : 009273 ( Main/Exploration ); précédent : 009272; suivant : 009274Normalization of nutritional status by various levels of vitamin E supplementation during murine AIDS
Auteurs : Yuejian Wang [États-Unis] ; Bailin Liang [États-Unis] ; Ronald R. Watson [États-Unis]Source :
- Nutrition Research [ 0271-5317 ] ; 1994.
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Abstract
Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine AIDS which is functionally similar to human AIDS. Dietary supplementation, with a 15-, 150- and 450-fold increase of vitamin E in a liquid diet (National Council Research), significantly restored serum and haptic vitamin A and E which had been reduced by retrovirus infection. They also significantly restored hepatic copper, which had been reduced by retrovirus infection, whereas only 150- and 450-fold vitamin E improved hepatic zinc level. Vitamin E supplementation at all levels had no effects on hepatic zinc and copper levels in normal mice, whereas they significantly increased serum and hepatic vitamin A and E concentrations. Vitamin E supplementation at all levels significantly increased intestinal vitamin A and E levels during murine AIDS, whereas only intestinal vitamin E levels was altered by various levels of vitamin E supplementation. Interestingly, vitamin E supplementation had no effect on intestinal copper level, whereas they significantly increased intestinal zinc level in the normal mice and only 450-fold vitamin E supplementation significantly elevated intestinal level of zinc. These data indicate that dietary vitamin E supplementation at extremely high levels was not toxic, can improve undernutrition initiated by retrovirus infection during progression to murine AIDS, which should favorably affect immune response.
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DOI: 10.1016/S0271-5317(05)80297-0
Affiliations:
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Dietary supplementation, with a 15-, 150- and 450-fold increase of vitamin E in a liquid diet (National Council Research), significantly restored serum and haptic vitamin A and E which had been reduced by retrovirus infection. They also significantly restored hepatic copper, which had been reduced by retrovirus infection, whereas only 150- and 450-fold vitamin E improved hepatic zinc level. Vitamin E supplementation at all levels had no effects on hepatic zinc and copper levels in normal mice, whereas they significantly increased serum and hepatic vitamin A and E concentrations. Vitamin E supplementation at all levels significantly increased intestinal vitamin A and E levels during murine AIDS, whereas only intestinal vitamin E levels was altered by various levels of vitamin E supplementation. Interestingly, vitamin E supplementation had no effect on intestinal copper level, whereas they significantly increased intestinal zinc level in the normal mice and only 450-fold vitamin E supplementation significantly elevated intestinal level of zinc. These data indicate that dietary vitamin E supplementation at extremely high levels was not toxic, can improve undernutrition initiated by retrovirus infection during progression to murine AIDS, which should favorably affect immune response.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li></region></list><tree><country name="États-Unis"><region name="Arizona"><name sortKey="Wang, Yuejian" sort="Wang, Yuejian" uniqKey="Wang Y" first="Yuejian" last="Wang">Yuejian Wang</name></region><name sortKey="Liang, Bailin" sort="Liang, Bailin" uniqKey="Liang B" first="Bailin" last="Liang">Bailin Liang</name><name sortKey="Liang, Bailin" sort="Liang, Bailin" uniqKey="Liang B" first="Bailin" last="Liang">Bailin Liang</name><name sortKey="Wang, Yuejian" sort="Wang, Yuejian" uniqKey="Wang Y" first="Yuejian" last="Wang">Yuejian Wang</name><name sortKey="Watson, Ronald R" sort="Watson, Ronald R" uniqKey="Watson R" first="Ronald R." last="Watson">Ronald R. 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