Cellular force measurement for force reflected biomanipulation
Identifieur interne : 006C67 ( Main/Exploration ); précédent : 006C66; suivant : 006C68Cellular force measurement for force reflected biomanipulation
Auteurs : Deok-Ho Kim [Corée du Sud] ; Byungkyu Kim [Corée du Sud] ; Seok Yun [Corée du Sud] ; Sangjoo Kwon [Corée du Sud]Source :
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In biological cell manipulations, manual thrust or penetration of injection pipette into single cells is usually performed by a skilled operator, relying on the visual feedback information only. Accurately measuring cellular force is a requirement for minimally invasive cell injection and it is essential in investigating biomechanical properties of cell membranes. We have fabricated an end-effector with microforce sensing capability for bio cell injections using PVDF piezoelectric polymer and measured several mN level Injection force for zebrafish egg cell. Experimental results show that the cellular force level is changed as the injection pipette penetrates yolk and chorion sequentially. As well, the experimental setup with haptic interface suggests that a more reliable blomanipulation can be achieved by supplying real-time cellular force feedback to the operator.
Affiliations:
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Le document en format XML
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Microsystems Research Center, Korea Institute of Science and Technology (KIST) P. O. Box 131</s1>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomechanics</term>
<term>Force control</term>
<term>Force measurement</term>
<term>Gripper</term>
<term>Membrane</term>
<term>Real time</term>
<term>Tactile sensitivity</term>
<term>Thrust</term>
<term>User interface</term>
<term>Vinylidene fluoride polymer</term>
<term>Visual information</term>
<term>Visual servoing</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Asservissement visuel</term>
<term>Temps réel</term>
<term>Commande force</term>
<term>Mesure force</term>
<term>Poussée</term>
<term>Information visuelle</term>
<term>Biomécanique</term>
<term>Membrane</term>
<term>Préhenseur</term>
<term>Vinylidène fluorure polymère</term>
<term>Interface utilisateur</term>
<term>Sensibilité tactile</term>
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<front><div type="abstract" xml:lang="en">In biological cell manipulations, manual thrust or penetration of injection pipette into single cells is usually performed by a skilled operator, relying on the visual feedback information only. Accurately measuring cellular force is a requirement for minimally invasive cell injection and it is essential in investigating biomechanical properties of cell membranes. We have fabricated an end-effector with microforce sensing capability for bio cell injections using PVDF piezoelectric polymer and measured several mN level Injection force for zebrafish egg cell. Experimental results show that the cellular force level is changed as the injection pipette penetrates yolk and chorion sequentially. As well, the experimental setup with haptic interface suggests that a more reliable blomanipulation can be achieved by supplying real-time cellular force feedback to the operator.</div>
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<affiliations><list><country><li>Corée du Sud</li>
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<name sortKey="Kim, Byungkyu" sort="Kim, Byungkyu" uniqKey="Kim B" first="Byungkyu" last="Kim">Byungkyu Kim</name>
<name sortKey="Kwon, Sangjoo" sort="Kwon, Sangjoo" uniqKey="Kwon S" first="Sangjoo" last="Kwon">Sangjoo Kwon</name>
<name sortKey="Yun, Seok" sort="Yun, Seok" uniqKey="Yun S" first="Seok" last="Yun">Seok Yun</name>
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