Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models
Identifieur interne : 003526 ( Main/Exploration ); précédent : 003525; suivant : 003527Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models
Auteurs : Lisa E. Williams [États-Unis] ; Vilayanur S. Ramachandran [États-Unis] ; Edward M. Hubbard [États-Unis] ; David L. Braff [États-Unis] ; Gregory A. Light [États-Unis]Source :
- Schizophrenia research [ 0920-9964 ] ; 2010.
Abstract
When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.
Url:
DOI: 10.1016/j.schres.2009.10.021
PubMed: 19931421
PubMed Central: 2910228
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P2">When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.</p>
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