Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models
Identifieur interne : 003526 ( Main/Exploration ); précédent : 003525; suivant : 003527Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models
Auteurs : Lisa E. Williams [États-Unis] ; Vilayanur S. Ramachandran [États-Unis] ; Edward M. Hubbard [États-Unis] ; David L. Braff [États-Unis] ; Gregory A. Light [États-Unis]Source :
- Schizophrenia research [ 0920-9964 ] ; 2010.
Abstract
When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.
Url:
DOI: 10.1016/j.schres.2009.10.021
PubMed: 19931421
PubMed Central: 2910228
Affiliations:
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Williams</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ramachandran, Vilayanur S" sort="Ramachandran, Vilayanur S" uniqKey="Ramachandran V" first="Vilayanur S." last="Ramachandran">Vilayanur S. 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Williams</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ramachandran, Vilayanur S" sort="Ramachandran, Vilayanur S" uniqKey="Ramachandran V" first="Vilayanur S." last="Ramachandran">Vilayanur S. Ramachandran</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hubbard, Edward M" sort="Hubbard, Edward M" uniqKey="Hubbard E" first="Edward M." last="Hubbard">Edward M. Hubbard</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Psychology and Human Development, Vanderbilt University, Peabody College #552, 230 Appleton Place, Nashville, TN 37203-5721, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychology and Human Development, Vanderbilt University, Peabody College #552, 230 Appleton Place, Nashville, TN 37203-5721</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Braff, David L" sort="Braff, David L" uniqKey="Braff D" first="David L." last="Braff">David L. Braff</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Psychiatry, University of California San Diego. 9500 Gilman Drive La Jolla, CA 92093-0804C, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychiatry, University of California San Diego. 9500 Gilman Drive La Jolla, CA 92093-0804C</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Light, Gregory A" sort="Light, Gregory A" uniqKey="Light G" first="Gregory A." last="Light">Gregory A. Light</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Psychiatry, University of California San Diego. 9500 Gilman Drive La Jolla, CA 92093-0804C, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Psychiatry, University of California San Diego. 9500 Gilman Drive La Jolla, CA 92093-0804C</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Schizophrenia research</title><idno type="ISSN">0920-9964</idno><idno type="eISSN">1573-2509</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Williams, Lisa E" sort="Williams, Lisa E" uniqKey="Williams L" first="Lisa E." last="Williams">Lisa E. Williams</name></region><name sortKey="Braff, David L" sort="Braff, David L" uniqKey="Braff D" first="David L." last="Braff">David L. Braff</name><name sortKey="Hubbard, Edward M" sort="Hubbard, Edward M" uniqKey="Hubbard E" first="Edward M." last="Hubbard">Edward M. Hubbard</name><name sortKey="Light, Gregory A" sort="Light, Gregory A" uniqKey="Light G" first="Gregory A." last="Light">Gregory A. Light</name><name sortKey="Ramachandran, Vilayanur S" sort="Ramachandran, Vilayanur S" uniqKey="Ramachandran V" first="Vilayanur S." last="Ramachandran">Vilayanur S. Ramachandran</name><name sortKey="Ramachandran, Vilayanur S" sort="Ramachandran, Vilayanur S" uniqKey="Ramachandran V" first="Vilayanur S." last="Ramachandran">Vilayanur S. Ramachandran</name><name sortKey="Williams, Lisa E" sort="Williams, Lisa E" uniqKey="Williams L" first="Lisa E." last="Williams">Lisa E. Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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