Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models
Identifieur interne : 001020 ( Pmc/Curation ); précédent : 001019; suivant : 001021Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models
Auteurs : Lisa E. Williams [États-Unis] ; Vilayanur S. Ramachandran [États-Unis] ; Edward M. Hubbard [États-Unis] ; David L. Braff [États-Unis] ; Gregory A. Light [États-Unis]Source :
- Schizophrenia research [ 0920-9964 ] ; 2010.
Abstract
When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.
Url:
DOI: 10.1016/j.schres.2009.10.021
PubMed: 19931421
PubMed Central: 2910228
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<front><div type="abstract" xml:lang="en"><p id="P2">When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.</p>
</div>
</front>
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<title-group><article-title>Superior Size-Weight Illusion Performance in Patients with Schizophrenia: Evidence for Deficits in Forward Models</article-title>
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<given-names>Lisa E.</given-names>
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Department of Psychology, University of California San Diego. 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</aff>
<aff id="A2"><label>b</label>
Center for Brain and Cognition, University of California San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, USA</aff>
<aff id="A3"><label>c</label>
Department of Psychology and Human Development, Vanderbilt University, Peabody College #552, 230 Appleton Place, Nashville, TN 37203-5721, USA</aff>
<aff id="A4"><label>d</label>
Department of Psychiatry, University of California San Diego. 9500 Gilman Drive La Jolla, CA 92093-0804C, USA</aff>
<author-notes><corresp id="FN1">Correspondence: Lisa E. Williams, Department of Psychology, University of California, San Diego, 9500 Gilman Drive #0109, La Jolla, CA 92093-0109, Tel: (858) 752-9619, Fax: (858) 534-7190, <email>lewilliams1@gmail.com</email>
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<year>2010</year>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>8</month>
<year>2011</year>
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<volume>121</volume>
<issue>1-3</issue>
<fpage>101</fpage>
<lpage>106</lpage>
<abstract><p id="P2">When non-psychiatric individuals compare the weights of two similar objects of identical mass, but of different sizes, the smaller object is often perceived as substantially heavier. This size-weight illusion (SWI) is thought to be generated by a violation of the common expectation that the large object will be heavier, possibly via a mismatch between an efference copy of the movement and the actual sensory feedback received. As previous research suggests patients with schizophrenia have deficits in forward model/efference copy mechanisms, we hypothesized that schizophrenic patients would show a reduced SWI. The current study compared the strength of the SWI in schizophrenic patients to matched non-psychiatric participants; weight discrimination for same-sized objects was also assessed. We found a reduced SWI for schizophrenic patients, which resulted in better (more veridical) weight discrimination performance on illusion trials compared to non-psychiatric individuals. This difference in the strength of the SWI persisted when groups were matched for weight discrimination performance. The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed.</p>
</abstract>
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<contract-num rid="MH1">R01 MH079777-02
||MH</contract-num>
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