Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex
Identifieur interne : 006612 ( Main/Curation ); précédent : 006611; suivant : 006613Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex
Auteurs : Le H. Hua [États-Unis] ; Irina A. Strigo [États-Unis] ; Leslie C. Baxter [États-Unis] ; Sterling C. Johnson [États-Unis] ; A. D. Craig [États-Unis]Source :
- American journal of physiology. Regulatory, integrative and comparative physiology [ 0363-6119 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Activation, Adult, Brain Mapping, Capacity, Cerebral Cortex (physiology), Cold Temperature, Cooling, Discrimination, Female, Functional imaging, Hand, Haptic perception, Human, Humans, Insular cortex, Localization, Magnetic Resonance Imaging, Male, Neck, Nuclear magnetic resonance imaging, Sensation, Skin Temperature (physiology), Somatotopy, Thermosensing (physiology).
- MESH :
- physiology : Cerebral Cortex, Skin Temperature, Thermosensing.
- Adult, Brain Mapping, Cold Temperature, Female, Hand, Humans, Magnetic Resonance Imaging, Male, Neck.
Abstract
Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation. which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.
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Pascal:06-0025445Le document en format XML
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<front><div type="abstract" xml:lang="en">Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation. which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.</div>
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<front><div type="abstract" xml:lang="en">Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation. which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.</div>
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<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.</title>
<author><name sortKey="Hua, Le H" sort="Hua, Le H" uniqKey="Hua L" first="Le H" last="Hua">Le H. Hua</name>
<affiliation wicri:level="2"><nlm:affiliation>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strigo, Irina A" sort="Strigo, Irina A" uniqKey="Strigo I" first="Irina A" last="Strigo">Irina A. Strigo</name>
</author>
<author><name sortKey="Baxter, Leslie C" sort="Baxter, Leslie C" uniqKey="Baxter L" first="Leslie C" last="Baxter">Leslie C. Baxter</name>
</author>
<author><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C" last="Johnson">Sterling C. Johnson</name>
</author>
<author><name sortKey="Craig, A D Bud" sort="Craig, A D Bud" uniqKey="Craig A" first="A D Bud" last="Craig">A D Bud Craig</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="doi">10.1152/ajpregu.00123.2005</idno>
<idno type="RBID">pubmed:15805097</idno>
<idno type="pmid">15805097</idno>
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<idno type="wicri:doubleKey">0363-6119:2005:Hua L:anteroposterior:somatotopy:of</idno>
<idno type="wicri:Area/Main/Merge">006572</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.</title>
<author><name sortKey="Hua, Le H" sort="Hua, Le H" uniqKey="Hua L" first="Le H" last="Hua">Le H. Hua</name>
<affiliation wicri:level="2"><nlm:affiliation>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strigo, Irina A" sort="Strigo, Irina A" uniqKey="Strigo I" first="Irina A" last="Strigo">Irina A. Strigo</name>
</author>
<author><name sortKey="Baxter, Leslie C" sort="Baxter, Leslie C" uniqKey="Baxter L" first="Leslie C" last="Baxter">Leslie C. Baxter</name>
</author>
<author><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C" last="Johnson">Sterling C. Johnson</name>
</author>
<author><name sortKey="Craig, A D Bud" sort="Craig, A D Bud" uniqKey="Craig A" first="A D Bud" last="Craig">A D Bud Craig</name>
</author>
</analytic>
<series><title level="j">American journal of physiology. Regulatory, integrative and comparative physiology</title>
<idno type="ISSN">0363-6119</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
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</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Brain Mapping</term>
<term>Cerebral Cortex (physiology)</term>
<term>Cold Temperature</term>
<term>Female</term>
<term>Hand</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neck</term>
<term>Skin Temperature (physiology)</term>
<term>Thermosensing (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebral Cortex</term>
<term>Skin Temperature</term>
<term>Thermosensing</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Brain Mapping</term>
<term>Cold Temperature</term>
<term>Female</term>
<term>Hand</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neck</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.</div>
</front>
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