Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.
Identifieur interne : 000739 ( Ncbi/Merge ); précédent : 000738; suivant : 000740Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.
Auteurs : Le H. Hua [États-Unis] ; Irina A. Strigo ; Leslie C. Baxter ; Sterling C. Johnson ; A D Bud CraigSource :
- American journal of physiology. Regulatory, integrative and comparative physiology [ 0363-6119 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- physiology : Cerebral Cortex, Skin Temperature, Thermosensing.
- Adult, Brain Mapping, Cold Temperature, Female, Hand, Humans, Magnetic Resonance Imaging, Male, Neck.
Abstract
Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.
DOI: 10.1152/ajpregu.00123.2005
PubMed: 15805097
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Baxter</name></author><author><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C" last="Johnson">Sterling C. Johnson</name></author><author><name sortKey="Craig, A D Bud" sort="Craig, A D Bud" uniqKey="Craig A" first="A D Bud" last="Craig">A D Bud Craig</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1152/ajpregu.00123.2005</idno><idno type="RBID">pubmed:15805097</idno><idno type="pmid">15805097</idno><idno type="wicri:Area/PubMed/Corpus">001948</idno><idno type="wicri:Area/PubMed/Curation">001948</idno><idno type="wicri:Area/PubMed/Checkpoint">001743</idno><idno type="wicri:Area/Ncbi/Merge">000739</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.</title><author><name sortKey="Hua, Le H" sort="Hua, Le H" uniqKey="Hua L" first="Le H" last="Hua">Le H. Hua</name><affiliation wicri:level="2"><nlm:affiliation>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Strigo, Irina A" sort="Strigo, Irina A" uniqKey="Strigo I" first="Irina A" last="Strigo">Irina A. Strigo</name></author><author><name sortKey="Baxter, Leslie C" sort="Baxter, Leslie C" uniqKey="Baxter L" first="Leslie C" last="Baxter">Leslie C. Baxter</name></author><author><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C" last="Johnson">Sterling C. Johnson</name></author><author><name sortKey="Craig, A D Bud" sort="Craig, A D Bud" uniqKey="Craig A" first="A D Bud" last="Craig">A D Bud Craig</name></author></analytic><series><title level="j">American journal of physiology. Regulatory, integrative and comparative physiology</title><idno type="ISSN">0363-6119</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Cerebral Cortex (physiology)</term><term>Cold Temperature</term><term>Female</term><term>Hand</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Neck</term><term>Skin Temperature (physiology)</term><term>Thermosensing (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebral Cortex</term><term>Skin Temperature</term><term>Thermosensing</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Cold Temperature</term><term>Female</term><term>Hand</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Neck</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15805097</PMID><DateCreated><Year>2005</Year><Month>07</Month><Day>14</Day></DateCreated><DateCompleted><Year>2005</Year><Month>09</Month><Day>01</Day></DateCompleted><DateRevised><Year>2010</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0363-6119</ISSN><JournalIssue CitedMedium="Print"><Volume>289</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Aug</Month></PubDate></JournalIssue><Title>American journal of physiology. Regulatory, integrative and comparative physiology</Title><ISOAbbreviation>Am. J. Physiol. Regul. Integr. Comp. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.</ArticleTitle><Pagination><MedlinePgn>R319-R325</MedlinePgn></Pagination><Abstract><AbstractText>Prior data indicate that graded activation by innocuous thermal stimuli occurs in the dorsal posterior insular (dpIns) cortex of humans, rather than the parietal somatosensory regions traditionally thought necessary for discriminative somatic sensations. We hypothesized that if the dpIns subserves the haptic capacity of localization in addition to discrimination, then it should be somatotopically organized. Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, we found unimodal foci arranged in an anteroposterior somatotopographic pattern, consistent with participation of the dpIns in localization as well as discrimination. This gradient is orthogonal to the mediolateral somatotopy of parietal somatosensory regions, which supports the fundamental conceptual differentiation of the interoceptive somatic representation in the dpIns from the parietal exteroceptive representations. These data also support the suggestion that the poststroke central pain syndrome associated with lesions of the dpIns is a thermoregulatory dysfunction. Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hua</LastName><ForeName>Le H</ForeName><Initials>le H</Initials><AffiliationInfo><Affiliation>Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strigo</LastName><ForeName>Irina A</ForeName><Initials>IA</Initials></Author><Author ValidYN="Y"><LastName>Baxter</LastName><ForeName>Leslie C</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Sterling C</ForeName><Initials>SC</Initials></Author><Author ValidYN="Y"><LastName>Craig</LastName><ForeName>A D Bud</ForeName><Initials>AD</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>NS 40413</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>03</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Physiol Regul Integr Comp Physiol</MedlineTA><NlmUniqueID>100901230</NlmUniqueID><ISSNLinking>0363-6119</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R317-R318</RefSource><PMID Version="1">16014447</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003080">Cold Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006225">Hand</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009333">Neck</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012881">Skin Temperature</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013697">Thermosensing</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2005</Year><Month>3</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>4</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>9</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>4</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">00123.2005</ArticleId><ArticleId IdType="doi">10.1152/ajpregu.00123.2005</ArticleId><ArticleId IdType="pubmed">15805097</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li></region></list><tree><noCountry><name sortKey="Baxter, Leslie C" sort="Baxter, Leslie C" uniqKey="Baxter L" first="Leslie C" last="Baxter">Leslie C. Baxter</name><name sortKey="Craig, A D Bud" sort="Craig, A D Bud" uniqKey="Craig A" first="A D Bud" last="Craig">A D Bud Craig</name><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C" last="Johnson">Sterling C. Johnson</name><name sortKey="Strigo, Irina A" sort="Strigo, Irina A" uniqKey="Strigo I" first="Irina A" last="Strigo">Irina A. Strigo</name></noCountry><country name="États-Unis"><region name="Arizona"><name sortKey="Hua, Le H" sort="Hua, Le H" uniqKey="Hua L" first="Le H" last="Hua">Le H. Hua</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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