Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane
Identifieur interne : 001054 ( Main/Curation ); précédent : 001053; suivant : 001055Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane
Auteurs : Rosanna La Rocca [Italie] ; Rossana Tallerico [Italie] ; Almosawy Talib Hassan [Italie, Iraq] ; Gobind Das [Italie] ; Lakshmikanth Tadepally [Suède] ; Marco Matteucci [Danemark] ; Carlo Liberale [Italie] ; Maria Mesuraca [Italie] ; Domenica Scumaci [Italie] ; Francesco Gentile [Italie] ; Gheorghe Cojoc [Italie] ; Gerardo Perozziello [Italie] ; Antonio Ammendolia [Italie] ; Adriana Gallo [Italie] ; Klas K Rre [Suède] ; Giovanni Cuda [Italie] ; Patrizio Candeloro [Italie] ; Enzo Di Fabrizio [Italie] ; Ennio Carbone [Italie, Suède]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
In our body, cells are continuously exposed to physical forces that can regulate different cell functions such as cell proliferation, differentiation and death. In this work, we employed two different strategies to mechanically stress cancer cells. The cancer and healthy cell populations were treated either with mechanical stress delivered by a micropump (fabricated by deep X-ray nanolithography) or by ultrasound wave stimuli. A specific down-regulation of Major Histocompatibility Complex (MHC) class I molecules expression on cancer cell membrane compared to different kinds of healthy cells (fibroblasts, macrophages, dendritic and lymphocyte cells) was observed, stimulating the cells with forces in the range of nano-newton, and pressures between 1 and 10 bar (1 bar = 100.000 Pascal), depending on the devices used. Moreover, Raman spectroscopy analysis, after mechanical treatment, in the range between 700–1800 cm−1, indicated a relative concentration variation of MHC class I. PCA analysis was also performed to distinguish control and stressed cells within different cell lines. These mechanical induced phenotypic changes increase the tumor immunogenicity, as revealed by the related increased susceptibility to Natural Killer (NK) cells cytotoxic recognition.
Url:
DOI: 10.1371/journal.pone.0111758
PubMed: 25541692
PubMed Central: 4277281
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Gobind Das<affiliation><nlm:aff id="aff4"><addr-line>King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia</addr-line>
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<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cojoc, Gheorghe" sort="Cojoc, Gheorghe" uniqKey="Cojoc G" first="Gheorghe" last="Cojoc">Gheorghe Cojoc</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perozziello, Gerardo" sort="Perozziello, Gerardo" uniqKey="Perozziello G" first="Gerardo" last="Perozziello">Gerardo Perozziello</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ammendolia, Antonio" sort="Ammendolia, Antonio" uniqKey="Ammendolia A" first="Antonio" last="Ammendolia">Antonio Ammendolia</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Surgical and Medical Sciences, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical and Medical Sciences, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gallo, Adriana" sort="Gallo, Adriana" uniqKey="Gallo A" first="Adriana" last="Gallo">Adriana Gallo</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Endocrinology and Experimental Oncology Institute, CNR, Napoli, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Endocrinology and Experimental Oncology Institute, CNR, Napoli</wicri:regionArea>
<wicri:noRegion>Napoli</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="K Rre, Klas" sort="K Rre, Klas" uniqKey="K Rre K" first="Klas" last="K Rre">Klas K Rre</name>
<affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cuda, Giovanni" sort="Cuda, Giovanni" uniqKey="Cuda G" first="Giovanni" last="Cuda">Giovanni Cuda</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Candeloro, Patrizio" sort="Candeloro, Patrizio" uniqKey="Candeloro P" first="Patrizio" last="Candeloro">Patrizio Candeloro</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Fabrizio, Enzo" sort="Di Fabrizio, Enzo" uniqKey="Di Fabrizio E" first="Enzo" last="Di Fabrizio">Enzo Di Fabrizio</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="aff4"><addr-line>King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Carbone, Ennio" sort="Carbone, Ennio" uniqKey="Carbone E" first="Ennio" last="Carbone">Ennio Carbone</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>In our body, cells are continuously exposed to physical forces that can regulate different cell functions such as cell proliferation, differentiation and death. In this work, we employed two different strategies to mechanically stress cancer cells. The cancer and healthy cell populations were treated either with mechanical stress delivered by a micropump (fabricated by deep X-ray nanolithography) or by ultrasound wave stimuli. A specific down-regulation of Major Histocompatibility Complex (MHC) class I molecules expression on cancer cell membrane compared to different kinds of healthy cells (fibroblasts, macrophages, dendritic and lymphocyte cells) was observed, stimulating the cells with forces in the range of nano-newton, and pressures between 1 and 10 bar (1 bar = 100.000 Pascal), depending on the devices used. Moreover, Raman spectroscopy analysis, after mechanical treatment, in the range between 700–1800 cm<sup>−1</sup>
, indicated a relative concentration variation of MHC class I. PCA analysis was also performed to distinguish control and stressed cells within different cell lines. These mechanical induced phenotypic changes increase the tumor immunogenicity, as revealed by the related increased susceptibility to Natural Killer (NK) cells cytotoxic recognition.</p>
</div>
</front>
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