Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Identifieur interne : 000479 ( Main/Exploration ); précédent : 000478; suivant : 000480Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Auteurs : Ivano De Filippis [Brésil, États-Unis] ; Ana Paula S. De Lemos [Brésil] ; Jessica B. Hostetler [États-Unis] ; Kurt Wollenberg [États-Unis] ; Claudio T. Sacchi [Brésil] ; Lee H. Harrison [États-Unis] ; Margaret C. Bash [États-Unis] ; D. Rebecca Prevots [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets
In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST),
A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST,
Url:
DOI: 10.1371/journal.pone.0033016
PubMed: 22431994
PubMed Central: 3303791
Affiliations:
- Brésil, États-Unis
- Maryland, Pennsylvanie, État de Rio de Janeiro
- Pittsburgh, Rio de Janeiro
- Université de Pittsburgh
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Epidemiology of <italic>Neisseria meningitidis</italic>
Serogroup B in Brazil</title>
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<author><name sortKey="De Lemos, Ana Paula S" sort="De Lemos, Ana Paula S" uniqKey="De Lemos A" first="Ana Paula S." last="De Lemos">Ana Paula S. De Lemos</name>
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<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Sacchi, Claudio T" sort="Sacchi, Claudio T" uniqKey="Sacchi C" first="Claudio T." last="Sacchi">Claudio T. Sacchi</name>
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</nlm:aff>
<country xml:lang="fr">Brésil</country>
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<author><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name>
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<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
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<author><name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<series><title level="j">PLoS ONE</title>
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<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><italic>Neisseria meningitidis</italic>
serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of São Paulo (1988–2006) for study (n = 372).</p>
</sec>
<sec><title>Methods</title>
<p>We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets <italic>fHbp</italic>
and <italic>nadA</italic>
.</p>
</sec>
<sec><title>Results</title>
<p>In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), <italic>fetA</italic>
, and <italic>porB</italic>
was significant but diversity was limited for <italic>nadA</italic>
and <italic>fHbp</italic>
. Between 1988 and 1996, the São Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, <italic>fHbp</italic>
variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of <italic>nadA</italic>
were similar to reference allele 1.</p>
</sec>
<sec><title>Conclusions</title>
<p>A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, <italic>fetA</italic>
, and <italic>porB</italic>
, but not in <italic>nadA</italic>
and <italic>fHbp</italic>
.</p>
</sec>
</div>
</front>
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</author>
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</author>
<author><name sortKey="Ramos, Sr" uniqKey="Ramos S">SR Ramos</name>
</author>
<author><name sortKey="Milagres, Lc" uniqKey="Milagres L">LC Milagres</name>
</author>
<author><name sortKey="Camargo, Mcc" uniqKey="Camargo M">MCC Camargo</name>
</author>
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</author>
<author><name sortKey="Gorla, Mc" uniqKey="Gorla M">MC Gorla</name>
</author>
<author><name sortKey="Paiva, Mv" uniqKey="Paiva M">MV Paiva</name>
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<author><name sortKey="Arnold, R" uniqKey="Arnold R">R Arnold</name>
</author>
<author><name sortKey="Huergo, Cc" uniqKey="Huergo C">CC Huergo</name>
</author>
<author><name sortKey="Oster, P" uniqKey="Oster P">P Oster</name>
</author>
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</author>
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</author>
<author><name sortKey="Masignani, V" uniqKey="Masignani V">V Masignani</name>
</author>
<author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name>
</author>
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</author>
<author><name sortKey="Barniak, V" uniqKey="Barniak V">V Barniak</name>
</author>
<author><name sortKey="Farley, Je" uniqKey="Farley J">JE Farley</name>
</author>
<author><name sortKey="Howell, A" uniqKey="Howell A">A Howell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name>
</author>
<author><name sortKey="Adu Bobie, J" uniqKey="Adu Bobie J">J Adu-Bobie</name>
</author>
<author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name>
</author>
<author><name sortKey="Arico, B" uniqKey="Arico B">B Arico</name>
</author>
<author><name sortKey="Savino, B" uniqKey="Savino B">B Savino</name>
</author>
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<biblStruct><analytic><author><name sortKey="Cordeiro, Sm" uniqKey="Cordeiro S">SM Cordeiro</name>
</author>
<author><name sortKey="Neves, Ab" uniqKey="Neves A">AB Neves</name>
</author>
<author><name sortKey="Ribeiro, Ct" uniqKey="Ribeiro C">CT Ribeiro</name>
</author>
<author><name sortKey="Petersen, Ml" uniqKey="Petersen M">ML Petersen</name>
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<author><name sortKey="Gouveia, El" uniqKey="Gouveia E">EL Gouveia</name>
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</author>
<author><name sortKey="Moraes, C" uniqKey="Moraes C">C Moraes</name>
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<author><name sortKey="Klein, C" uniqKey="Klein C">C Klein</name>
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<author><name sortKey="Popovic, T" uniqKey="Popovic T">T Popovic</name>
</author>
<author><name sortKey="De Moraes, Jc" uniqKey="De Moraes J">JC de Moraes</name>
</author>
<author><name sortKey="Whitney, Am" uniqKey="Whitney A">AM Whitney</name>
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</author>
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</author>
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<author><name sortKey="Arico, B" uniqKey="Arico B">B Arico</name>
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<author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name>
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<author><name sortKey="Bambini, S" uniqKey="Bambini S">S Bambini</name>
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</TEI>
<affiliations><list><country><li>Brésil</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Pennsylvanie</li>
<li>État de Rio de Janeiro</li>
</region>
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<name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name>
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