Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Identifieur interne : 000294 ( Ncbi/Merge ); précédent : 000293; suivant : 000295Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Auteurs : Ivano De Filippis [Brésil, États-Unis] ; Ana Paula S. De Lemos [Brésil] ; Jessica B. Hostetler [États-Unis] ; Kurt Wollenberg [États-Unis] ; Claudio T. Sacchi [Brésil] ; Lee H. Harrison [États-Unis] ; Margaret C. Bash [États-Unis] ; D. Rebecca Prevots [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets
In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST),
A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST,
Url:
DOI: 10.1371/journal.pone.0033016
PubMed: 22431994
PubMed Central: 3303791
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Serogroup B in Brazil</title>
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<author><name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name>
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</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Epidemiology of <italic>Neisseria meningitidis</italic>
Serogroup B in Brazil</title>
<author><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name>
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<country xml:lang="fr">Brésil</country>
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<placeName><settlement type="city">Rio de Janeiro</settlement>
<region type="state">État de Rio de Janeiro</region>
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<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Maryland</region>
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</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line>
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</author>
<author><name sortKey="De Lemos, Ana Paula S" sort="De Lemos, Ana Paula S" uniqKey="De Lemos A" first="Ana Paula S." last="De Lemos">Ana Paula S. De Lemos</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo</wicri:regionArea>
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<author><name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B." last="Hostetler">Jessica B. Hostetler</name>
<affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>J. Craig Venter Institute (JCVI), Rockville, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>J. Craig Venter Institute (JCVI), Rockville, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Wollenberg, Kurt" sort="Wollenberg, Kurt" uniqKey="Wollenberg K" first="Kurt" last="Wollenberg">Kurt Wollenberg</name>
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</nlm:aff>
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<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sacchi, Claudio T" sort="Sacchi, Claudio T" uniqKey="Sacchi C" first="Claudio T." last="Sacchi">Claudio T. Sacchi</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Immunology, Instituto Adolfo Lutz, São Paolo, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Immunology, Instituto Adolfo Lutz, São Paolo</wicri:regionArea>
<wicri:noRegion>São Paolo</wicri:noRegion>
</affiliation>
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<author><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name>
<affiliation wicri:level="4"><nlm:aff id="aff8"><addr-line>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line>
</nlm:aff>
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<wicri:regionArea>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
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</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><italic>Neisseria meningitidis</italic>
serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of São Paulo (1988–2006) for study (n = 372).</p>
</sec>
<sec><title>Methods</title>
<p>We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets <italic>fHbp</italic>
and <italic>nadA</italic>
.</p>
</sec>
<sec><title>Results</title>
<p>In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), <italic>fetA</italic>
, and <italic>porB</italic>
was significant but diversity was limited for <italic>nadA</italic>
and <italic>fHbp</italic>
. Between 1988 and 1996, the São Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, <italic>fHbp</italic>
variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of <italic>nadA</italic>
were similar to reference allele 1.</p>
</sec>
<sec><title>Conclusions</title>
<p>A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, <italic>fetA</italic>
, and <italic>porB</italic>
, but not in <italic>nadA</italic>
and <italic>fHbp</italic>
.</p>
</sec>
</div>
</front>
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</author>
<author><name sortKey="Pessoa, Ll" uniqKey="Pessoa L">LL Pessoa</name>
</author>
<author><name sortKey="Ramos, Sr" uniqKey="Ramos S">SR Ramos</name>
</author>
<author><name sortKey="Milagres, Lc" uniqKey="Milagres L">LC Milagres</name>
</author>
<author><name sortKey="Camargo, Mcc" uniqKey="Camargo M">MCC Camargo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Lemos, Ap" uniqKey="De Lemos A">AP de Lemos</name>
</author>
<author><name sortKey="Yara, Ty" uniqKey="Yara T">TY Yara</name>
</author>
<author><name sortKey="Gorla, Mc" uniqKey="Gorla M">MC Gorla</name>
</author>
<author><name sortKey="Paiva, Mv" uniqKey="Paiva M">MV Paiva</name>
</author>
<author><name sortKey="De Souza, Al" uniqKey="De Souza A">AL de Souza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holst, J" uniqKey="Holst J">J Holst</name>
</author>
<author><name sortKey="Martin, D" uniqKey="Martin D">D Martin</name>
</author>
<author><name sortKey="Arnold, R" uniqKey="Arnold R">R Arnold</name>
</author>
<author><name sortKey="Huergo, Cc" uniqKey="Huergo C">CC Huergo</name>
</author>
<author><name sortKey="Oster, P" uniqKey="Oster P">P Oster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pizza, M" uniqKey="Pizza M">M Pizza</name>
</author>
<author><name sortKey="Scarlato, V" uniqKey="Scarlato V">V Scarlato</name>
</author>
<author><name sortKey="Masignani, V" uniqKey="Masignani V">V Masignani</name>
</author>
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</author>
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</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Fletcher, Ld" uniqKey="Fletcher L">LD Fletcher</name>
</author>
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</author>
<author><name sortKey="Barniak, V" uniqKey="Barniak V">V Barniak</name>
</author>
<author><name sortKey="Farley, Je" uniqKey="Farley J">JE Farley</name>
</author>
<author><name sortKey="Howell, A" uniqKey="Howell A">A Howell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giuliani, Mm" uniqKey="Giuliani M">MM Giuliani</name>
</author>
<author><name sortKey="Adu Bobie, J" uniqKey="Adu Bobie J">J Adu-Bobie</name>
</author>
<author><name sortKey="Comanducci, M" uniqKey="Comanducci M">M Comanducci</name>
</author>
<author><name sortKey="Arico, B" uniqKey="Arico B">B Arico</name>
</author>
<author><name sortKey="Savino, B" uniqKey="Savino B">B Savino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cordeiro, Sm" uniqKey="Cordeiro S">SM Cordeiro</name>
</author>
<author><name sortKey="Neves, Ab" uniqKey="Neves A">AB Neves</name>
</author>
<author><name sortKey="Ribeiro, Ct" uniqKey="Ribeiro C">CT Ribeiro</name>
</author>
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<author><name sortKey="Gouveia, El" uniqKey="Gouveia E">EL Gouveia</name>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Baethgen, Lf" uniqKey="Baethgen L">LF Baethgen</name>
</author>
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<biblStruct><analytic><author><name sortKey="Sacchi, Ct" uniqKey="Sacchi C">CT Sacchi</name>
</author>
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</author>
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<biblStruct><analytic><author><name sortKey="Madico, G" uniqKey="Madico G">G Madico</name>
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<author><name sortKey="Welsch, Ja" uniqKey="Welsch J">JA Welsch</name>
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</author>
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</author>
<author><name sortKey="Perlman, Dh" uniqKey="Perlman D">DH Perlman</name>
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</biblStruct>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22431994</article-id>
<article-id pub-id-type="pmc">3303791</article-id>
<article-id pub-id-type="publisher-id">PONE-D-11-20560</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0033016</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Biology</subject>
<subj-group><subject>Microbiology</subject>
</subj-group>
<subj-group><subject>Population Biology</subject>
<subj-group><subject>Epidemiology</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Computer Science</subject>
<subj-group><subject>Computer Modeling</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject>
<subj-group><subject>Epidemiology</subject>
</subj-group>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Bacterial Diseases</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Molecular Epidemiology of <italic>Neisseria meningitidis</italic>
Serogroup B in Brazil</article-title>
<alt-title alt-title-type="running-head"><italic>Neisseria meningitidis</italic>
Serogroup B in Brazil</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>de Filippis</surname>
<given-names>Ivano</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Lemos</surname>
<given-names>Ana Paula S.</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hostetler</surname>
<given-names>Jessica B.</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="author-notes" rid="fn1"><sup>¤</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wollenberg</surname>
<given-names>Kurt</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sacchi</surname>
<given-names>Claudio T.</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harrison</surname>
<given-names>Lee H.</given-names>
</name>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Bash</surname>
<given-names>Margaret C.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Prevots</surname>
<given-names>D. Rebecca</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>National Quality Control Institute (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>Department of Bacteriology, Instituto Adolfo Lutz (IAL), São Paolo, Brazil</addr-line>
</aff>
<aff id="aff5"><label>5</label>
<addr-line>J. Craig Venter Institute (JCVI), Rockville, Maryland, United States of America</addr-line>
</aff>
<aff id="aff6"><label>6</label>
<addr-line>Office of Cyberinfrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America</addr-line>
</aff>
<aff id="aff7"><label>7</label>
<addr-line>Department of Immunology, Instituto Adolfo Lutz, São Paolo, Brazil</addr-line>
</aff>
<aff id="aff8"><label>8</label>
<addr-line>Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Borrow</surname>
<given-names>Ray</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">Health Protection Agency, United Kingdom</aff>
<author-notes><corresp id="cor1">* E-mail: <email>rprevots@niaid.nih.gov</email>
</corresp>
<fn fn-type="con"><p>Conceived and designed the experiments: IDF CTS MCB DRP. Performed the experiments: IDF APL JBH KW CTS MCB DRP. Analyzed the data: IDF JBH KW MCB DRP. Contributed reagents/materials/analysis tools: IDF APL JBH KW CTS LHH MCB DRP. Wrote the paper: IDF KW MCB DRP.</p>
</fn>
<fn id="fn1" fn-type="current-aff"><label>¤</label>
<p>Current address: National Institutes of Health Oxford-Cambridge Scholars Program, United Kingdom</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>14</day>
<month>3</month>
<year>2012</year>
</pub-date>
<volume>7</volume>
<issue>3</issue>
<elocation-id>e33016</elocation-id>
<history><date date-type="received"><day>19</day>
<month>10</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>3</day>
<month>2</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><sec><title>Background</title>
<p><italic>Neisseria meningitidis</italic>
serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of São Paulo (1988–2006) for study (n = 372).</p>
</sec>
<sec><title>Methods</title>
<p>We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets <italic>fHbp</italic>
and <italic>nadA</italic>
.</p>
</sec>
<sec><title>Results</title>
<p>In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), <italic>fetA</italic>
, and <italic>porB</italic>
was significant but diversity was limited for <italic>nadA</italic>
and <italic>fHbp</italic>
. Between 1988 and 1996, the São Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, <italic>fHbp</italic>
variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of <italic>nadA</italic>
were similar to reference allele 1.</p>
</sec>
<sec><title>Conclusions</title>
<p>A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, <italic>fetA</italic>
, and <italic>porB</italic>
, but not in <italic>nadA</italic>
and <italic>fHbp</italic>
.</p>
</sec>
</abstract>
<counts><page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Brésil</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Pennsylvanie</li>
<li>État de Rio de Janeiro</li>
</region>
<settlement><li>Pittsburgh</li>
<li>Rio de Janeiro</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name>
</region>
<name sortKey="De Lemos, Ana Paula S" sort="De Lemos, Ana Paula S" uniqKey="De Lemos A" first="Ana Paula S." last="De Lemos">Ana Paula S. De Lemos</name>
<name sortKey="Sacchi, Claudio T" sort="Sacchi, Claudio T" uniqKey="Sacchi C" first="Claudio T." last="Sacchi">Claudio T. Sacchi</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name>
</region>
<name sortKey="Bash, Margaret C" sort="Bash, Margaret C" uniqKey="Bash M" first="Margaret C." last="Bash">Margaret C. Bash</name>
<name sortKey="De Filippis, Ivano" sort="De Filippis, Ivano" uniqKey="De Filippis I" first="Ivano" last="De Filippis">Ivano De Filippis</name>
<name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name>
<name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B." last="Hostetler">Jessica B. Hostetler</name>
<name sortKey="Prevots, D Rebecca" sort="Prevots, D Rebecca" uniqKey="Prevots D" first="D. Rebecca" last="Prevots">D. Rebecca Prevots</name>
<name sortKey="Wollenberg, Kurt" sort="Wollenberg, Kurt" uniqKey="Wollenberg K" first="Kurt" last="Wollenberg">Kurt Wollenberg</name>
</country>
</tree>
</affiliations>
</record>
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