Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.
Identifieur interne : 000313 ( Ncbi/Curation ); précédent : 000312; suivant : 000314Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.
Auteurs : Isao Tawara [États-Unis] ; Motoko Koyama ; Chen Liu ; Tomomi Toubai ; Dafydd Thomas ; Rebecca Evers ; Peter Chockley ; Evelyn Nieves ; Yaping Sun ; Kathleen P. Lowler ; Chelsea Malter ; Norihiro Nishimoto ; Geoffrey R. Hill ; Pavan ReddySource :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (pharmacologie), Femelle, Interleukine-6 (antagonistes et inhibiteurs), Interleukine-6 (déficit), Interleukine-6 (immunologie), Maladie du greffon contre l'hôte (), Maladie du greffon contre l'hôte (immunologie), Souris, Souris de lignée BALB C, Souris de lignée C3H, Souris de lignée C57BL, Souris de lignée DBA, Souris de souche-129, Transplantation de moelle osseuse (immunologie), Transplantation homologue.
- MESH :
- antagonistes et inhibiteurs : Interleukine-6.
- déficit : Interleukine-6.
- immunologie : Interleukine-6, Maladie du greffon contre l'hôte, Transplantation de moelle osseuse.
- pharmacologie : Anticorps monoclonaux.
- Animaux, Femelle, Maladie du greffon contre l'hôte, Souris, Souris de lignée BALB C, Souris de lignée C3H, Souris de lignée C57BL, Souris de lignée DBA, Souris de souche-129, Transplantation homologue.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (pharmacology), Bone Marrow Transplantation (immunology), Female, Graft vs Host Disease (immunology), Graft vs Host Disease (therapy), Interleukin-6 (antagonists & inhibitors), Interleukin-6 (deficiency), Interleukin-6 (immunology), Mice, Mice, 129 Strain, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Transplantation, Homologous.
- MESH :
- chemical , antagonists & inhibitors : Interleukin-6.
- chemical , deficiency : Interleukin-6.
- chemical , immunology : Interleukin-6.
- chemical , pharmacology : Antibodies, Monoclonal.
- immunology : Bone Marrow Transplantation, Graft vs Host Disease.
- therapy : Graft vs Host Disease.
- Animals, Female, Mice, Mice, 129 Strain, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Transplantation, Homologous.
Abstract
The graft-versus-tumor (GVT) effect is a potent form of immunotherapy against many hematologic malignancies and some solid tumors. The beneficial GVT effect after allogeneic bone marrow transplantation (BMT) is tightly linked to its most significant complication, graft-versus-host disease (GVHD). The role of interleukin-6 (IL-6) after allogeneic BMT is not well understood. This study used a series of complementary knockout and antibody blockade strategies to analyze the impact of IL-6 in multiple clinically relevant murine models of GVHD and GVT.
DOI: 10.1158/1078-0432.CCR-10-1198
PubMed: 21047980
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001B10
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001B10
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001889
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000313
Links to Exploration step
pubmed:21047980Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.</title><author><name sortKey="Tawara, Isao" sort="Tawara, Isao" uniqKey="Tawara I" first="Isao" last="Tawara">Isao Tawara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0942, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0942</wicri:regionArea><wicri:noRegion>Michigan 48109-0942</wicri:noRegion></affiliation></author><author><name sortKey="Koyama, Motoko" sort="Koyama, Motoko" uniqKey="Koyama M" first="Motoko" last="Koyama">Motoko Koyama</name></author><author><name sortKey="Liu, Chen" sort="Liu, Chen" uniqKey="Liu C" first="Chen" last="Liu">Chen Liu</name></author><author><name sortKey="Toubai, Tomomi" sort="Toubai, Tomomi" uniqKey="Toubai T" first="Tomomi" last="Toubai">Tomomi Toubai</name></author><author><name sortKey="Thomas, Dafydd" sort="Thomas, Dafydd" uniqKey="Thomas D" first="Dafydd" last="Thomas">Dafydd Thomas</name></author><author><name sortKey="Evers, Rebecca" sort="Evers, Rebecca" uniqKey="Evers R" first="Rebecca" last="Evers">Rebecca Evers</name></author><author><name sortKey="Chockley, Peter" sort="Chockley, Peter" uniqKey="Chockley P" first="Peter" last="Chockley">Peter Chockley</name></author><author><name sortKey="Nieves, Evelyn" sort="Nieves, Evelyn" uniqKey="Nieves E" first="Evelyn" last="Nieves">Evelyn Nieves</name></author><author><name sortKey="Sun, Yaping" sort="Sun, Yaping" uniqKey="Sun Y" first="Yaping" last="Sun">Yaping Sun</name></author><author><name sortKey="Lowler, Kathleen P" sort="Lowler, Kathleen P" uniqKey="Lowler K" first="Kathleen P" last="Lowler">Kathleen P. Lowler</name></author><author><name sortKey="Malter, Chelsea" sort="Malter, Chelsea" uniqKey="Malter C" first="Chelsea" last="Malter">Chelsea Malter</name></author><author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name></author><author><name sortKey="Hill, Geoffrey R" sort="Hill, Geoffrey R" uniqKey="Hill G" first="Geoffrey R" last="Hill">Geoffrey R. Hill</name></author><author><name sortKey="Reddy, Pavan" sort="Reddy, Pavan" uniqKey="Reddy P" first="Pavan" last="Reddy">Pavan Reddy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21047980</idno><idno type="pmid">21047980</idno><idno type="doi">10.1158/1078-0432.CCR-10-1198</idno><idno type="wicri:Area/PubMed/Corpus">001B10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B10</idno><idno type="wicri:Area/PubMed/Curation">001B10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B10</idno><idno type="wicri:Area/PubMed/Checkpoint">001889</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001889</idno><idno type="wicri:Area/Ncbi/Merge">000313</idno><idno type="wicri:Area/Ncbi/Curation">000313</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.</title><author><name sortKey="Tawara, Isao" sort="Tawara, Isao" uniqKey="Tawara I" first="Isao" last="Tawara">Isao Tawara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0942, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0942</wicri:regionArea><wicri:noRegion>Michigan 48109-0942</wicri:noRegion></affiliation></author><author><name sortKey="Koyama, Motoko" sort="Koyama, Motoko" uniqKey="Koyama M" first="Motoko" last="Koyama">Motoko Koyama</name></author><author><name sortKey="Liu, Chen" sort="Liu, Chen" uniqKey="Liu C" first="Chen" last="Liu">Chen Liu</name></author><author><name sortKey="Toubai, Tomomi" sort="Toubai, Tomomi" uniqKey="Toubai T" first="Tomomi" last="Toubai">Tomomi Toubai</name></author><author><name sortKey="Thomas, Dafydd" sort="Thomas, Dafydd" uniqKey="Thomas D" first="Dafydd" last="Thomas">Dafydd Thomas</name></author><author><name sortKey="Evers, Rebecca" sort="Evers, Rebecca" uniqKey="Evers R" first="Rebecca" last="Evers">Rebecca Evers</name></author><author><name sortKey="Chockley, Peter" sort="Chockley, Peter" uniqKey="Chockley P" first="Peter" last="Chockley">Peter Chockley</name></author><author><name sortKey="Nieves, Evelyn" sort="Nieves, Evelyn" uniqKey="Nieves E" first="Evelyn" last="Nieves">Evelyn Nieves</name></author><author><name sortKey="Sun, Yaping" sort="Sun, Yaping" uniqKey="Sun Y" first="Yaping" last="Sun">Yaping Sun</name></author><author><name sortKey="Lowler, Kathleen P" sort="Lowler, Kathleen P" uniqKey="Lowler K" first="Kathleen P" last="Lowler">Kathleen P. Lowler</name></author><author><name sortKey="Malter, Chelsea" sort="Malter, Chelsea" uniqKey="Malter C" first="Chelsea" last="Malter">Chelsea Malter</name></author><author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name></author><author><name sortKey="Hill, Geoffrey R" sort="Hill, Geoffrey R" uniqKey="Hill G" first="Geoffrey R" last="Hill">Geoffrey R. Hill</name></author><author><name sortKey="Reddy, Pavan" sort="Reddy, Pavan" uniqKey="Reddy P" first="Pavan" last="Reddy">Pavan Reddy</name></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (pharmacology)</term><term>Bone Marrow Transplantation (immunology)</term><term>Female</term><term>Graft vs Host Disease (immunology)</term><term>Graft vs Host Disease (therapy)</term><term>Interleukin-6 (antagonists & inhibitors)</term><term>Interleukin-6 (deficiency)</term><term>Interleukin-6 (immunology)</term><term>Mice</term><term>Mice, 129 Strain</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred DBA</term><term>Transplantation, Homologous</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux (pharmacologie)</term><term>Femelle</term><term>Interleukine-6 (antagonistes et inhibiteurs)</term><term>Interleukine-6 (déficit)</term><term>Interleukine-6 (immunologie)</term><term>Maladie du greffon contre l'hôte ()</term><term>Maladie du greffon contre l'hôte (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris de lignée C57BL</term><term>Souris de lignée DBA</term><term>Souris de souche-129</term><term>Transplantation de moelle osseuse (immunologie)</term><term>Transplantation homologue</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interleukine-6</term><term>Maladie du greffon contre l'hôte</term><term>Transplantation de moelle osseuse</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bone Marrow Transplantation</term><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, 129 Strain</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred DBA</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Maladie du greffon contre l'hôte</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris de lignée C57BL</term><term>Souris de lignée DBA</term><term>Souris de souche-129</term><term>Transplantation homologue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The graft-versus-tumor (GVT) effect is a potent form of immunotherapy against many hematologic malignancies and some solid tumors. The beneficial GVT effect after allogeneic bone marrow transplantation (BMT) is tightly linked to its most significant complication, graft-versus-host disease (GVHD). The role of interleukin-6 (IL-6) after allogeneic BMT is not well understood. This study used a series of complementary knockout and antibody blockade strategies to analyze the impact of IL-6 in multiple clinically relevant murine models of GVHD and GVT.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/TocilizumabV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000313 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000313 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= TocilizumabV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:21047980
|texte= Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:21047980" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a TocilizumabV1
| This area was generated with Dilib version V0.6.34. |  |