Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.
Identifieur interne : 001B10 ( PubMed/Curation ); précédent : 001B09; suivant : 001B11Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.
Auteurs : Isao Tawara [États-Unis] ; Motoko Koyama ; Chen Liu ; Tomomi Toubai ; Dafydd Thomas ; Rebecca Evers ; Peter Chockley ; Evelyn Nieves ; Yaping Sun ; Kathleen P. Lowler ; Chelsea Malter ; Norihiro Nishimoto ; Geoffrey R. Hill ; Pavan ReddySource :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (pharmacologie), Femelle, Interleukine-6 (antagonistes et inhibiteurs), Interleukine-6 (déficit), Interleukine-6 (immunologie), Maladie du greffon contre l'hôte (), Maladie du greffon contre l'hôte (immunologie), Souris, Souris de lignée BALB C, Souris de lignée C3H, Souris de lignée C57BL, Souris de lignée DBA, Souris de souche-129, Transplantation de moelle osseuse (immunologie), Transplantation homologue.
- MESH :
- antagonistes et inhibiteurs : Interleukine-6.
- déficit : Interleukine-6.
- immunologie : Interleukine-6, Maladie du greffon contre l'hôte, Transplantation de moelle osseuse.
- pharmacologie : Anticorps monoclonaux.
- Animaux, Femelle, Maladie du greffon contre l'hôte, Souris, Souris de lignée BALB C, Souris de lignée C3H, Souris de lignée C57BL, Souris de lignée DBA, Souris de souche-129, Transplantation homologue.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (pharmacology), Bone Marrow Transplantation (immunology), Female, Graft vs Host Disease (immunology), Graft vs Host Disease (therapy), Interleukin-6 (antagonists & inhibitors), Interleukin-6 (deficiency), Interleukin-6 (immunology), Mice, Mice, 129 Strain, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Transplantation, Homologous.
- MESH :
- chemical , antagonists & inhibitors : Interleukin-6.
- chemical , deficiency : Interleukin-6.
- chemical , immunology : Interleukin-6.
- chemical , pharmacology : Antibodies, Monoclonal.
- immunology : Bone Marrow Transplantation, Graft vs Host Disease.
- therapy : Graft vs Host Disease.
- Animals, Female, Mice, Mice, 129 Strain, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Transplantation, Homologous.
Abstract
The graft-versus-tumor (GVT) effect is a potent form of immunotherapy against many hematologic malignancies and some solid tumors. The beneficial GVT effect after allogeneic bone marrow transplantation (BMT) is tightly linked to its most significant complication, graft-versus-host disease (GVHD). The role of interleukin-6 (IL-6) after allogeneic BMT is not well understood. This study used a series of complementary knockout and antibody blockade strategies to analyze the impact of IL-6 in multiple clinically relevant murine models of GVHD and GVT.
DOI: 10.1158/1078-0432.CCR-10-1198
PubMed: 21047980
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Lowler</name></author><author><name sortKey="Malter, Chelsea" sort="Malter, Chelsea" uniqKey="Malter C" first="Chelsea" last="Malter">Chelsea Malter</name></author><author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name></author><author><name sortKey="Hill, Geoffrey R" sort="Hill, Geoffrey R" uniqKey="Hill G" first="Geoffrey R" last="Hill">Geoffrey R. Hill</name></author><author><name sortKey="Reddy, Pavan" sort="Reddy, Pavan" uniqKey="Reddy P" first="Pavan" last="Reddy">Pavan Reddy</name></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (pharmacology)</term><term>Bone Marrow Transplantation (immunology)</term><term>Female</term><term>Graft vs Host Disease (immunology)</term><term>Graft vs Host Disease (therapy)</term><term>Interleukin-6 (antagonists & inhibitors)</term><term>Interleukin-6 (deficiency)</term><term>Interleukin-6 (immunology)</term><term>Mice</term><term>Mice, 129 Strain</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred DBA</term><term>Transplantation, Homologous</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux (pharmacologie)</term><term>Femelle</term><term>Interleukine-6 (antagonistes et inhibiteurs)</term><term>Interleukine-6 (déficit)</term><term>Interleukine-6 (immunologie)</term><term>Maladie du greffon contre l'hôte ()</term><term>Maladie du greffon contre l'hôte (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris de lignée C57BL</term><term>Souris de lignée DBA</term><term>Souris de souche-129</term><term>Transplantation de moelle osseuse (immunologie)</term><term>Transplantation homologue</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interleukine-6</term><term>Maladie du greffon contre l'hôte</term><term>Transplantation de moelle osseuse</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bone Marrow Transplantation</term><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, 129 Strain</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred DBA</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Maladie du greffon contre l'hôte</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris de lignée C57BL</term><term>Souris de lignée DBA</term><term>Souris de souche-129</term><term>Transplantation homologue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The graft-versus-tumor (GVT) effect is a potent form of immunotherapy against many hematologic malignancies and some solid tumors. The beneficial GVT effect after allogeneic bone marrow transplantation (BMT) is tightly linked to its most significant complication, graft-versus-host disease (GVHD). The role of interleukin-6 (IL-6) after allogeneic BMT is not well understood. This study used a series of complementary knockout and antibody blockade strategies to analyze the impact of IL-6 in multiple clinically relevant murine models of GVHD and GVT.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21047980</PMID><DateCompleted><Year>2011</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1078-0432</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>1</Issue><PubDate><Year>2011</Year><Month>Jan</Month><Day>01</Day></PubDate></JournalIssue><Title>Clinical cancer research : an official journal of the American Association for Cancer Research</Title><ISOAbbreviation>Clin. Cancer Res.</ISOAbbreviation></Journal><ArticleTitle>Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.</ArticleTitle><Pagination><MedlinePgn>77-88</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1078-0432.CCR-10-1198</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The graft-versus-tumor (GVT) effect is a potent form of immunotherapy against many hematologic malignancies and some solid tumors. The beneficial GVT effect after allogeneic bone marrow transplantation (BMT) is tightly linked to its most significant complication, graft-versus-host disease (GVHD). The role of interleukin-6 (IL-6) after allogeneic BMT is not well understood. This study used a series of complementary knockout and antibody blockade strategies to analyze the impact of IL-6 in multiple clinically relevant murine models of GVHD and GVT.</AbstractText><AbstractText Label="EXPERIMENTAL DESIGN" NlmCategory="METHODS">We examined the effect of the source of IL-6 by analyzing the role IL-6 deficiency in donor T cells, donor bone marrow or in host tissues. We confirmed and extended the relevance of IL-6 deficiency on GVHD and GVT by treating BMT recipients with anti-mouse IL-6 receptor (IL-6R), MR16-1.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Deficiency of IL-6 in donor T cells led to prolongation of survival. Total inhibition of IL-6 with MR16-1 caused an even greater reduction in GVHD-induced mortality. The reduction in GVHD was independent of the direct effects on T effector cell expansion or donor regulatory T cells. GVT responses were preserved after treatment with MR16-1.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">MR16-1 treatment reduced GVHD and preserved sufficient GVT. Tocilizumab, a humanized anti-IL-6R monoclonal antibody (mAb), is approved in several countries including the United States and European Union for the treatment of rheumatoid arthritis and other inflammatory diseases. Blockade of IL-6 with anti-IL-6R mAb therapy may be testable in clinical trials as an adjunct to prevent GVHD in BMT patients without a significant loss of GVT.</AbstractText><CopyrightInformation>©2010 AACR.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tawara</LastName><ForeName>Isao</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0942, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koyama</LastName><ForeName>Motoko</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Chen</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Toubai</LastName><ForeName>Tomomi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Dafydd</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Evers</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Chockley</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Nieves</LastName><ForeName>Evelyn</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yaping</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Lowler</LastName><ForeName>Kathleen P</ForeName><Initials>KP</Initials></Author><Author ValidYN="Y"><LastName>Malter</LastName><ForeName>Chelsea</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Nishimoto</LastName><ForeName>Norihiro</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Geoffrey R</ForeName><Initials>GR</Initials></Author><Author ValidYN="Y"><LastName>Reddy</LastName><ForeName>Pavan</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI075284-04</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL-090775</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI-075284</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL090775-04</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI075284</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL090775</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>11</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Cancer Res</MedlineTA><NlmUniqueID>9502500</NlmUniqueID><ISSNLinking>1078-0432</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016026" MajorTopicYN="N">Bone Marrow Transplantation</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006086" MajorTopicYN="N">Graft vs Host Disease</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057507" MajorTopicYN="N">Mice, 129 Strain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008809" MajorTopicYN="N">Mice, Inbred C3H</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008811" MajorTopicYN="N">Mice, Inbred DBA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014184" MajorTopicYN="N">Transplantation, Homologous</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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