Serveur d'exploration Tocilizumab - Exploration (Accueil)

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Index : AbsEn.i

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Les termes de plus forte occurence

3092patients
2817arthritis
2515treatment
2427tocilizumab
2367disease
2347rheumatoid
1741clinical
1438therapy
1352anti
1310study
1140receptor
1135interleukin
1102inflammatory
1061these
1027associated
1005cell
996were
925review
920efficacy
889therapeutic
880response
877may
870antibody
836patient
828drugs
809after
799treated
797but
789factor
781systemic
778also
762title
759results
755however
749cells
738diseases
721activity
713other
698data
694tnf
690agents
687new
674studies
671effects
666role
655biologic
652safety
632drug
623including
608therapies
604case
591most
588well
583immune
577inflammation
564development
559tumor
559biological
557first
556severe
555necrosis
554both
549risk
540high
535chronic
534levels
533who
533trials
527sec
527analysis
523potential
512effective
511cytokine
510increased
507abstract
506there
506during
495syndrome
491all
487report
483methotrexate
481monoclonal
481effect
478tcz
475years
474modifying
470inhibitors
466management
465related
453refractory
447remission
447idiopathic
447autoimmune
445current
437year
437significant
434evidence
429non
427pathogenesis
425than
422rituximab
419juvenile
418early
418compared
415induced
414important
413rheumatic
413cases
404recent
399biologics
398adverse
397human
392specific
391novel
387long
386protein
385factors
378reported
377still
377although
376background
376acute
373cytokines
370different
369several
368only
368diagnosis
364significantly
364abatacept
362serum
361onset
361joint
361against
360symptoms
356term
356showed
351present
350had
349active
348dose
346due
343target
343inhibitor
341antibodies
334expression
333life
332controlled
331infection
330common
329evaluate
322outcomes
318available
313low
313cancer
312literature
311treatments
311par
311further
310targeting
310phase
309could
309antirheumatic
307will
306while
306system
306shown
305objective
304events
303activation
300humanized
300developed
297mechanisms
295arteritis
294combination
293improved
293conventional
292trial
292therefore
292aim
290large
290characterized
289progression
288over
288observed
286mediated
286inhibition
285should
284months
284administration
280effectiveness
275many
274currently
272various
272practice
272demonstrated
270blockade
268addition
267responses
266when
266weeks
266approved
265function
264control
263without
263those
263signaling
261found
261findings
260old
260involved
260infections
258infliximab
255rate
254adult
254adalimumab
252strategies
252provide
252number
250targeted
250dmards
249suggest
249recently
249multiple
247through
247randomized
247improvement
245time
244whether
244group
243rare
242etanercept
240major
240here
239changes
238understanding
238type
237impact
236rheumatology
236following
236evaluated
234three
231higher
231agent
230key
228vasculitis
227options
226tissue
226production
226approach
225cohort
224often
224manifestations
224future
224damage
223outcome
223disorders
223blood
223assess
222bone
221antigen
217disorder
216reduced
216possible
216increase
214level
214italic
214failure
213treat
212pathway
212immunosuppressive
211positive
211identified
211children
210involvement
210investigated
210course
210complications
209remains
209primary
208under
208despite
208care
208age
207reactive
207monotherapy
207investigate
207conditions
207assessment
206model
206health
206being
205limited
205because
204pathways
204considered
203promising
203known
202research
201line
201experience
200thus
200methods
198score
197elevated
196population
195survival
193systematic
193giant
193assessed
192need
192decreased
192criteria
192association
191describe
190single
190better
189within
189successful
189advances
187gene
186castleman
185receiving
185molecular
184treating
184targets
184quality
183strategy
183serious
183profile
183evaluation
182unknown
182real
181improve
181especially
181article
180since
180like
179mechanism
179covid
178include
178fever
178conclusion
177features
177cause
177baseline
176joints
176growth
176established
176corticosteroids
176cardiovascular
175respectively
175moderate
173aimed
172rates
172inadequate
172before
171mtx
171mortality
171intravenous
171characteristics
170determine
169lung
169alpha
168total
168might
168complex
167pro
167jia
167included
167discuss
166world
166sclerosis
165lower
165introduction
165follow
164regarding
164identify
163prognosis
163performed
163each
162week
162small
162secondary
162even
161skin
161play
161fri
160underlying
159markers
158side
158leading
156versus
156similar
155received
154vitro
154knowledge
153revealed
153reports
152thu
152renal
152oral
152option
152loss
152every
151overall
150release
150reduction
150increasing
149previously
149needed
149laboratory
149critical
148tumour
148retrospective
148glucocorticoids
148furthermore
147chimeric
146very
146standard
146second
146remain
146published
146previous
146models
145process
145potentially
145good
145did
145achieved
145according
143diagnostic
143diagnosed
143condition
143any
142approaches
141pain
141lupus
141administered
140presence
140caused
140benefit
140alternative
139particularly
139das
139comparison
139anakinra
138takayasu
138result
138rapid
138peripheral
138less
138few
137synovial
137lead
137incidence
137highly
136via
136successfully
136given
136described
136antagonist
135presented
135led
135either
134placebo
134moreover
134influence
134four
134focus
133plays
133observational
133now
133mainly
132negative
132medical
132last
132european
132dependent
132compare
132central
132action
131show
130soluble
130regulatory
130plasma
130label
130initial
130develop
130biomarkers
129vascular
129purpose
129meta
129genetic
128whereas
128useful
128molecules
128imaging
128emerging
128cost
128blocking

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