Observations on the relationship in chickens between the virulence of some avian influenza viruses and their pathogenicity for various organs.
Identifieur interne : 000A66 ( PubMed/Corpus ); précédent : 000A65; suivant : 000A67Observations on the relationship in chickens between the virulence of some avian influenza viruses and their pathogenicity for various organs.
Auteurs : P T Hooper ; G W Russell ; P W Selleck ; W L StanislawekSource :
- Avian diseases [ 0005-2086 ]
English descriptors
- KwdEn :
- Animals, Brain (pathology), Brain (virology), Chickens, Disease Susceptibility, Immunohistochemistry, Influenza A virus (pathogenicity), Influenza in Birds (etiology), Influenza in Birds (metabolism), Influenza in Birds (pathology), Kidney (pathology), Kidney (virology), Myocarditis (etiology), Myocarditis (pathology), Myocarditis (veterinary), Organ Specificity, Retrospective Studies, Virulence.
- MESH :
- etiology : Influenza in Birds, Myocarditis.
- metabolism : Influenza in Birds.
- pathogenicity : Influenza A virus.
- pathology : Brain, Influenza in Birds, Kidney, Myocarditis.
- veterinary : Myocarditis.
- virology : Brain, Kidney.
- Animals, Chickens, Disease Susceptibility, Immunohistochemistry, Organ Specificity, Retrospective Studies, Virulence.
Abstract
Comparative histological and immunocytochemical studies were conducted on formalin-fixed tissues from chickens infected with avian influenza viruses of varying virulence. Results showed a distinct pattern of disease that depended on the virulence of the virus and the susceptibility of the birds. At 3 days post-intranasal inoculation with a highly virulent H7N7 virus, all 6-to-8-week-old specific-pathogen-free (SPF) birds were affected, and all developed pancreatic necrosis and encephalitis associated with specific immunoperoxidase staining. Other same-aged SPF birds were only occasionally affected 6 to 8 days after intravenous inoculation with almost avirulent H4N4, H6N2, or H3N8 virus. Specific lesions and immunoperoxidase staining were noted in the kidneys only. The H7N7 virus in older commercial birds and an H7N3 virus in young SPF and older commercial birds caused intermediate mortality rates at 4 to 11 days postinoculation, and there was a broad range of lesions and specific immunoperoxidase staining in the pancreas, brain, kidney, heart, and skeletal muscle. Two exceptional birds had immunostaining of small blood vessels throughout their bodies with or without lesions or staining in the tissues, which may have represented a transitory pre-localizing phase occurring in many birds. There was necrosis without virus antigen detection in the bursae, thymuses, and cecal tonsils, possibly secondary to stress or only transitory infection of virus. These data indicate that rapid, retrospective diagnosis of avian influenza in fixed tissues is possible by using an immunoperoxidase test on pancreas, brain, and kidney.
PubMed: 8561728
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pubmed:8561728Le document en format XML
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Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Russell, G W" sort="Russell, G W" uniqKey="Russell G" first="G W" last="Russell">G W Russell</name></author><author><name sortKey="Selleck, P W" sort="Selleck, P W" uniqKey="Selleck P" first="P W" last="Selleck">P W Selleck</name></author><author><name sortKey="Stanislawek, W L" sort="Stanislawek, W L" uniqKey="Stanislawek W" first="W L" last="Stanislawek">W L Stanislawek</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1995 Jul-Sep</MedlineDate></PubDate></date><idno type="RBID">pubmed:8561728</idno><idno type="pmid">8561728</idno><idno type="wicri:Area/PubMed/Corpus">000A66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A66</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Observations on the relationship in chickens between the virulence of some avian influenza viruses and their pathogenicity for various organs.</title><author><name sortKey="Hooper, P T" sort="Hooper, P T" uniqKey="Hooper P" first="P T" last="Hooper">P T Hooper</name><affiliation><nlm:affiliation>C.S.I.R.O. Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Russell, G W" sort="Russell, G W" uniqKey="Russell G" first="G W" last="Russell">G W Russell</name></author><author><name sortKey="Selleck, P W" sort="Selleck, P W" uniqKey="Selleck P" first="P W" last="Selleck">P W Selleck</name></author><author><name sortKey="Stanislawek, W L" sort="Stanislawek, W L" uniqKey="Stanislawek W" first="W L" last="Stanislawek">W L Stanislawek</name></author></analytic><series><title level="j">Avian diseases</title><idno type="ISSN">0005-2086</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (pathology)</term><term>Brain (virology)</term><term>Chickens</term><term>Disease Susceptibility</term><term>Immunohistochemistry</term><term>Influenza A virus (pathogenicity)</term><term>Influenza in Birds (etiology)</term><term>Influenza in Birds (metabolism)</term><term>Influenza in Birds (pathology)</term><term>Kidney (pathology)</term><term>Kidney (virology)</term><term>Myocarditis (etiology)</term><term>Myocarditis (pathology)</term><term>Myocarditis (veterinary)</term><term>Organ Specificity</term><term>Retrospective Studies</term><term>Virulence</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Influenza in Birds</term><term>Myocarditis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Influenza in Birds</term><term>Kidney</term><term>Myocarditis</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Myocarditis</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Kidney</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Disease Susceptibility</term><term>Immunohistochemistry</term><term>Organ Specificity</term><term>Retrospective Studies</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Comparative histological and immunocytochemical studies were conducted on formalin-fixed tissues from chickens infected with avian influenza viruses of varying virulence. Results showed a distinct pattern of disease that depended on the virulence of the virus and the susceptibility of the birds. At 3 days post-intranasal inoculation with a highly virulent H7N7 virus, all 6-to-8-week-old specific-pathogen-free (SPF) birds were affected, and all developed pancreatic necrosis and encephalitis associated with specific immunoperoxidase staining. Other same-aged SPF birds were only occasionally affected 6 to 8 days after intravenous inoculation with almost avirulent H4N4, H6N2, or H3N8 virus. Specific lesions and immunoperoxidase staining were noted in the kidneys only. The H7N7 virus in older commercial birds and an H7N3 virus in young SPF and older commercial birds caused intermediate mortality rates at 4 to 11 days postinoculation, and there was a broad range of lesions and specific immunoperoxidase staining in the pancreas, brain, kidney, heart, and skeletal muscle. Two exceptional birds had immunostaining of small blood vessels throughout their bodies with or without lesions or staining in the tissues, which may have represented a transitory pre-localizing phase occurring in many birds. There was necrosis without virus antigen detection in the bursae, thymuses, and cecal tonsils, possibly secondary to stress or only transitory infection of virus. These data indicate that rapid, retrospective diagnosis of avian influenza in fixed tissues is possible by using an immunoperoxidase test on pancreas, brain, and kidney.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8561728</PMID><DateCompleted><Year>1996</Year><Month>02</Month><Day>27</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0005-2086</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>3</Issue><PubDate><MedlineDate>1995 Jul-Sep</MedlineDate></PubDate></JournalIssue><Title>Avian diseases</Title><ISOAbbreviation>Avian Dis.</ISOAbbreviation></Journal><ArticleTitle>Observations on the relationship in chickens between the virulence of some avian influenza viruses and their pathogenicity for various organs.</ArticleTitle><Pagination><MedlinePgn>458-64</MedlinePgn></Pagination><Abstract><AbstractText>Comparative histological and immunocytochemical studies were conducted on formalin-fixed tissues from chickens infected with avian influenza viruses of varying virulence. Results showed a distinct pattern of disease that depended on the virulence of the virus and the susceptibility of the birds. At 3 days post-intranasal inoculation with a highly virulent H7N7 virus, all 6-to-8-week-old specific-pathogen-free (SPF) birds were affected, and all developed pancreatic necrosis and encephalitis associated with specific immunoperoxidase staining. Other same-aged SPF birds were only occasionally affected 6 to 8 days after intravenous inoculation with almost avirulent H4N4, H6N2, or H3N8 virus. Specific lesions and immunoperoxidase staining were noted in the kidneys only. The H7N7 virus in older commercial birds and an H7N3 virus in young SPF and older commercial birds caused intermediate mortality rates at 4 to 11 days postinoculation, and there was a broad range of lesions and specific immunoperoxidase staining in the pancreas, brain, kidney, heart, and skeletal muscle. Two exceptional birds had immunostaining of small blood vessels throughout their bodies with or without lesions or staining in the tissues, which may have represented a transitory pre-localizing phase occurring in many birds. There was necrosis without virus antigen detection in the bursae, thymuses, and cecal tonsils, possibly secondary to stress or only transitory infection of virus. These data indicate that rapid, retrospective diagnosis of avian influenza in fixed tissues is possible by using an immunoperoxidase test on pancreas, brain, and kidney.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hooper</LastName><ForeName>P T</ForeName><Initials>PT</Initials><AffiliationInfo><Affiliation>C.S.I.R.O. Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>G W</ForeName><Initials>GW</Initials></Author><Author ValidYN="Y"><LastName>Selleck</LastName><ForeName>P W</ForeName><Initials>PW</Initials></Author><Author ValidYN="Y"><LastName>Stanislawek</LastName><ForeName>W L</ForeName><Initials>WL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Avian Dis</MedlineTA><NlmUniqueID>0370617</NlmUniqueID><ISSNLinking>0005-2086</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009205" MajorTopicYN="N">Myocarditis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009928" MajorTopicYN="Y">Organ Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8561728</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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