European swine virus as a possible source for the next influenza pandemic?
Identifieur interne : 000A65 ( PubMed/Corpus ); précédent : 000A64; suivant : 000A66European swine virus as a possible source for the next influenza pandemic?
Auteurs : S. Ludwig ; L. Stitz ; O. Planz ; H. Van ; W M Fitch ; C. ScholtissekSource :
- Virology [ 0042-6822 ] ; 1995.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral (analysis), Chick Embryo, Disease Outbreaks, Europe, Evolution, Molecular, Genes, Viral (genetics), Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Humans, Influenza A virus (genetics), Influenza A virus (growth & development), Influenza A virus (immunology), Influenza, Human (epidemiology), Influenza, Human (virology), Molecular Sequence Data, Mutagenesis (genetics), Neutralization Tests, Phylogeny, RNA, Viral (genetics), Sequence Analysis, DNA, Species Specificity, Swine.
- MESH :
- chemical , analysis : Antigens, Viral.
- chemical , genetics : Hemagglutinins, Viral, RNA, Viral.
- chemical , immunology : Hemagglutinins, Viral.
- chemical : Antibodies, Monoclonal, Antibodies, Viral.
- geographic : Europe.
- epidemiology : Influenza, Human.
- genetics : Genes, Viral, Influenza A virus, Mutagenesis.
- growth & development : Influenza A virus.
- immunology : Influenza A virus.
- virology : Influenza, Human.
- Animals, Chick Embryo, Disease Outbreaks, Evolution, Molecular, Humans, Molecular Sequence Data, Neutralization Tests, Phylogeny, Sequence Analysis, DNA, Species Specificity, Swine.
Abstract
According to phylogenetic data, about 100 years ago an avian influenza virus passed the species barrier (possibly first) to pigs and (possibly from there) to humans. In 1979 an avian influenza A virus (as a whole, without reassortment) again entered the pig population in northern Europe, forming a stable lineage. Here it is shown that the early North European swine viruses exhibit higher than normal evolutionary rates and are highly variable with respect to plaque morphology and neutralizability by monoclonal antibodies. Our results are consistent with the idea that, in order to pass the species barrier, an influenza A virus needs a mutator mutation to provide an additional number of variants, from which the new host might select the best fitting ones. A mutator mutation could be of advantage under such stress conditions and might enable a virus to pass the species barrier as a whole even twice, as it seems to have happened about 100 years ago. This stressful situation should be over for the recent swine lineage, since the viruses seem to be adapted already to the new host in that the most recent isolates--at least in northern Germany--are genetically stable and seem to have lost the putative mutator mutation again.
DOI: 10.1006/viro.1995.1513
PubMed: 7571425
Links to Exploration step
pubmed:7571425Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">European swine virus as a possible source for the next influenza pandemic?</title><author><name sortKey="Ludwig, S" sort="Ludwig, S" uniqKey="Ludwig S" first="S" last="Ludwig">S. Ludwig</name><affiliation><nlm:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stitz, L" sort="Stitz, L" uniqKey="Stitz L" first="L" last="Stitz">L. Stitz</name></author><author><name sortKey="Planz, O" sort="Planz, O" uniqKey="Planz O" first="O" last="Planz">O. Planz</name></author><author><name sortKey="Van, H" sort="Van, H" uniqKey="Van H" first="H" last="Van">H. Van</name></author><author><name sortKey="Fitch, W M" sort="Fitch, W M" uniqKey="Fitch W" first="W M" last="Fitch">W M Fitch</name></author><author><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C" last="Scholtissek">C. Scholtissek</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7571425</idno><idno type="pmid">7571425</idno><idno type="doi">10.1006/viro.1995.1513</idno><idno type="wicri:Area/PubMed/Corpus">000A65</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">European swine virus as a possible source for the next influenza pandemic?</title><author><name sortKey="Ludwig, S" sort="Ludwig, S" uniqKey="Ludwig S" first="S" last="Ludwig">S. Ludwig</name><affiliation><nlm:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stitz, L" sort="Stitz, L" uniqKey="Stitz L" first="L" last="Stitz">L. Stitz</name></author><author><name sortKey="Planz, O" sort="Planz, O" uniqKey="Planz O" first="O" last="Planz">O. Planz</name></author><author><name sortKey="Van, H" sort="Van, H" uniqKey="Van H" first="H" last="Van">H. Van</name></author><author><name sortKey="Fitch, W M" sort="Fitch, W M" uniqKey="Fitch W" first="W M" last="Fitch">W M Fitch</name></author><author><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C" last="Scholtissek">C. Scholtissek</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term><term>Antigens, Viral (analysis)</term><term>Chick Embryo</term><term>Disease Outbreaks</term><term>Europe</term><term>Evolution, Molecular</term><term>Genes, Viral (genetics)</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (immunology)</term><term>Humans</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (growth & development)</term><term>Influenza A virus (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Molecular Sequence Data</term><term>Mutagenesis (genetics)</term><term>Neutralization Tests</term><term>Phylogeny</term><term>RNA, Viral (genetics)</term><term>Sequence Analysis, DNA</term><term>Species Specificity</term><term>Swine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, Viral</term><term>Influenza A virus</term><term>Mutagenesis</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chick Embryo</term><term>Disease Outbreaks</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Neutralization Tests</term><term>Phylogeny</term><term>Sequence Analysis, DNA</term><term>Species Specificity</term><term>Swine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">According to phylogenetic data, about 100 years ago an avian influenza virus passed the species barrier (possibly first) to pigs and (possibly from there) to humans. In 1979 an avian influenza A virus (as a whole, without reassortment) again entered the pig population in northern Europe, forming a stable lineage. Here it is shown that the early North European swine viruses exhibit higher than normal evolutionary rates and are highly variable with respect to plaque morphology and neutralizability by monoclonal antibodies. Our results are consistent with the idea that, in order to pass the species barrier, an influenza A virus needs a mutator mutation to provide an additional number of variants, from which the new host might select the best fitting ones. A mutator mutation could be of advantage under such stress conditions and might enable a virus to pass the species barrier as a whole even twice, as it seems to have happened about 100 years ago. This stressful situation should be over for the recent swine lineage, since the viruses seem to be adapted already to the new host in that the most recent isolates--at least in northern Germany--are genetically stable and seem to have lost the putative mutator mutation again.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7571425</PMID><DateCompleted><Year>1995</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0042-6822</ISSN><JournalIssue CitedMedium="Print"><Volume>212</Volume><Issue>2</Issue><PubDate><Year>1995</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>European swine virus as a possible source for the next influenza pandemic?</ArticleTitle><Pagination><MedlinePgn>555-61</MedlinePgn></Pagination><Abstract><AbstractText>According to phylogenetic data, about 100 years ago an avian influenza virus passed the species barrier (possibly first) to pigs and (possibly from there) to humans. In 1979 an avian influenza A virus (as a whole, without reassortment) again entered the pig population in northern Europe, forming a stable lineage. Here it is shown that the early North European swine viruses exhibit higher than normal evolutionary rates and are highly variable with respect to plaque morphology and neutralizability by monoclonal antibodies. Our results are consistent with the idea that, in order to pass the species barrier, an influenza A virus needs a mutator mutation to provide an additional number of variants, from which the new host might select the best fitting ones. A mutator mutation could be of advantage under such stress conditions and might enable a virus to pass the species barrier as a whole even twice, as it seems to have happened about 100 years ago. This stressful situation should be over for the recent swine lineage, since the viruses seem to be adapted already to the new host in that the most recent isolates--at least in northern Germany--are genetically stable and seem to have lost the putative mutator mutation again.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ludwig</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stitz</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Planz</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Van</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Fitch</LastName><ForeName>W M</ForeName><Initials>WM</Initials></Author><Author ValidYN="Y"><LastName>Scholtissek</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>D00406</AccessionNumber><AccessionNumber>D00407</AccessionNumber><AccessionNumber>D00841</AccessionNumber><AccessionNumber>K01330</AccessionNumber><AccessionNumber>K01331</AccessionNumber><AccessionNumber>L19012</AccessionNumber><AccessionNumber>L19021</AccessionNumber><AccessionNumber>L19028</AccessionNumber><AccessionNumber>L33488</AccessionNumber><AccessionNumber>L33489</AccessionNumber><AccessionNumber>L33490</AccessionNumber><AccessionNumber>L33493</AccessionNumber><AccessionNumber>L33755</AccessionNumber><AccessionNumber>L33756</AccessionNumber><AccessionNumber>L33757</AccessionNumber><AccessionNumber>M33748</AccessionNumber><AccessionNumber>M38353</AccessionNumber><AccessionNumber>M59324</AccessionNumber><AccessionNumber>M59325</AccessionNumber><AccessionNumber>M59326</AccessionNumber><AccessionNumber>M59327</AccessionNumber><AccessionNumber>M59328</AccessionNumber><AccessionNumber>X00027</AccessionNumber><AccessionNumber>X00028</AccessionNumber><AccessionNumber>X00029</AccessionNumber><AccessionNumber>X00030</AccessionNumber><AccessionNumber>X00031</AccessionNumber><AccessionNumber>X17224</AccessionNumber><AccessionNumber>X59778</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Virology</MedlineTA><NlmUniqueID>0110674</NlmUniqueID><ISSNLinking>0042-6822</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002642" MajorTopicYN="N">Chick Embryo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005814" MajorTopicYN="N">Genes, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016296" MajorTopicYN="N">Mutagenesis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7571425</ArticleId><ArticleId IdType="pii">S0042-6822(85)71513-9</ArticleId><ArticleId IdType="doi">10.1006/viro.1995.1513</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000A65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:7571425
|texte= European swine virus as a possible source for the next influenza pandemic?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:7571425" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |