Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection.
Identifieur interne : 000711 ( PubMed/Corpus ); précédent : 000710; suivant : 000712Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection.
Auteurs : Amanda M. Jamieson ; Shuang Yu ; Charles H. Annicelli ; Ruslan MedzhitovSource :
- Cell host & microbe [ 1934-6069 ] ; 2010.
English descriptors
- KwdEn :
- Albumins (analysis), Animals, Bronchoalveolar Lavage Fluid (chemistry), Colony Count, Microbial, Cytokines (analysis), Glucocorticoids (blood), Glucocorticoids (immunology), Humans, Immune Tolerance, Immunity, Innate, Influenza A Virus, H1N1 Subtype (immunology), Listeria monocytogenes (isolation & purification), Listeriosis (immunology), Liver (microbiology), Lung (pathology), Mice, Mice, Inbred C57BL, Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Spleen (microbiology), Survival Analysis, Viral Load.
- MESH :
- chemical , analysis : Albumins, Cytokines.
- chemical , blood : Glucocorticoids.
- chemistry : Bronchoalveolar Lavage Fluid.
- complications : Orthomyxoviridae Infections.
- chemical , immunology : Glucocorticoids, Influenza A Virus, H1N1 Subtype, Listeriosis, Orthomyxoviridae Infections.
- isolation & purification : Listeria monocytogenes.
- microbiology : Liver, Spleen.
- pathology : Lung, Orthomyxoviridae Infections.
- Animals, Colony Count, Microbial, Humans, Immune Tolerance, Immunity, Innate, Mice, Mice, Inbred C57BL, Survival Analysis, Viral Load.
Abstract
Multicellular organisms are continuously exposed to many different pathogens. Because different classes of pathogens require different types of immune responses, understanding how an ongoing immune response to one type of infection affects the host's ability to respond to another pathogen is essential for a complete understanding of host-pathogen interactions. Here, we used a mouse model of coinfection to gain insight into the effect of respiratory influenza virus infection on a subsequent systemic bacterial infection. We found that influenza infection triggered a generalized stress response leading to a sustained increase in serum glucocorticoid levels, resulting in a systemic suppression of immune responses. However, virus-induced glucocorticoid production was necessary to control the inflammatory response and prevent lethal immunopathology during coinfection. This study demonstrates that activation of the hypothalamic-pituitary-adrenal axis controls the balance between immune defense and immunopathology and is an important component of the host response to coinfection.
DOI: 10.1016/j.chom.2010.01.010
PubMed: 20159617
Links to Exploration step
pubmed:20159617Le document en format XML
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Annicelli</name></author><author><name sortKey="Medzhitov, Ruslan" sort="Medzhitov, Ruslan" uniqKey="Medzhitov R" first="Ruslan" last="Medzhitov">Ruslan Medzhitov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20159617</idno><idno type="pmid">20159617</idno><idno type="doi">10.1016/j.chom.2010.01.010</idno><idno type="wicri:Area/PubMed/Corpus">000711</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000711</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection.</title><author><name sortKey="Jamieson, Amanda M" sort="Jamieson, Amanda M" uniqKey="Jamieson A" first="Amanda M" last="Jamieson">Amanda M. Jamieson</name><affiliation><nlm:affiliation>Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Shuang" sort="Yu, Shuang" uniqKey="Yu S" first="Shuang" last="Yu">Shuang Yu</name></author><author><name sortKey="Annicelli, Charles H" sort="Annicelli, Charles H" uniqKey="Annicelli C" first="Charles H" last="Annicelli">Charles H. Annicelli</name></author><author><name sortKey="Medzhitov, Ruslan" sort="Medzhitov, Ruslan" uniqKey="Medzhitov R" first="Ruslan" last="Medzhitov">Ruslan Medzhitov</name></author></analytic><series><title level="j">Cell host & microbe</title><idno type="eISSN">1934-6069</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albumins (analysis)</term><term>Animals</term><term>Bronchoalveolar Lavage Fluid (chemistry)</term><term>Colony Count, Microbial</term><term>Cytokines (analysis)</term><term>Glucocorticoids (blood)</term><term>Glucocorticoids (immunology)</term><term>Humans</term><term>Immune Tolerance</term><term>Immunity, Innate</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Listeria monocytogenes (isolation & purification)</term><term>Listeriosis (immunology)</term><term>Liver (microbiology)</term><term>Lung (pathology)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Orthomyxoviridae Infections (complications)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Spleen (microbiology)</term><term>Survival Analysis</term><term>Viral Load</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Albumins</term><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Bronchoalveolar Lavage Fluid</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Glucocorticoids</term><term>Influenza A Virus, H1N1 Subtype</term><term>Listeriosis</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Listeria monocytogenes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Liver</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Colony Count, Microbial</term><term>Humans</term><term>Immune Tolerance</term><term>Immunity, Innate</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Survival Analysis</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multicellular organisms are continuously exposed to many different pathogens. Because different classes of pathogens require different types of immune responses, understanding how an ongoing immune response to one type of infection affects the host's ability to respond to another pathogen is essential for a complete understanding of host-pathogen interactions. Here, we used a mouse model of coinfection to gain insight into the effect of respiratory influenza virus infection on a subsequent systemic bacterial infection. We found that influenza infection triggered a generalized stress response leading to a sustained increase in serum glucocorticoid levels, resulting in a systemic suppression of immune responses. However, virus-induced glucocorticoid production was necessary to control the inflammatory response and prevent lethal immunopathology during coinfection. This study demonstrates that activation of the hypothalamic-pituitary-adrenal axis controls the balance between immune defense and immunopathology and is an important component of the host response to coinfection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20159617</PMID><DateCompleted><Year>2010</Year><Month>05</Month><Day>03</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1934-6069</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Feb</Month><Day>18</Day></PubDate></JournalIssue><Title>Cell host & microbe</Title><ISOAbbreviation>Cell Host Microbe</ISOAbbreviation></Journal><ArticleTitle>Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection.</ArticleTitle><Pagination><MedlinePgn>103-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chom.2010.01.010</ELocationID><Abstract><AbstractText>Multicellular organisms are continuously exposed to many different pathogens. Because different classes of pathogens require different types of immune responses, understanding how an ongoing immune response to one type of infection affects the host's ability to respond to another pathogen is essential for a complete understanding of host-pathogen interactions. Here, we used a mouse model of coinfection to gain insight into the effect of respiratory influenza virus infection on a subsequent systemic bacterial infection. We found that influenza infection triggered a generalized stress response leading to a sustained increase in serum glucocorticoid levels, resulting in a systemic suppression of immune responses. However, virus-induced glucocorticoid production was necessary to control the inflammatory response and prevent lethal immunopathology during coinfection. This study demonstrates that activation of the hypothalamic-pituitary-adrenal axis controls the balance between immune defense and immunopathology and is an important component of the host response to coinfection.</AbstractText><CopyrightInformation>2010 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jamieson</LastName><ForeName>Amanda M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Shuang</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Annicelli</LastName><ForeName>Charles H</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Medzhitov</LastName><ForeName>Ruslan</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R37 AI046688-09</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI055502</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI055502</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK071754</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK071754-03</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI046688</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AI046688</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Howard Hughes Medical Institute</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK071754</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI046688</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United 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Jul;137(1):35-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15196241</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2004 Jul;2(7):552-68</Citation><ArticleIdList><ArticleId IdType="pubmed">15197391</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2004 Aug 16;200(4):527-33</Citation><ArticleIdList><ArticleId IdType="pubmed">15302899</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2004 Aug 16;200(4):535-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15302900</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2004 Aug 16;200(4):437-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15302901</ArticleId></ArticleIdList></Reference><Reference><Citation>FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):189-95</Citation><ArticleIdList><ArticleId IdType="pubmed">10575129</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Rev. 2000 Apr;174:150-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10807514</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2000 Jul;74(13):6105-16</Citation><ArticleIdList><ArticleId IdType="pubmed">10846094</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9317-22</Citation><ArticleIdList><ArticleId IdType="pubmed">10922080</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2000 Dec;74(24):11566-73</Citation><ArticleIdList><ArticleId IdType="pubmed">11090154</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine Growth Factor Rev. 2001 Jun-Sep;12(2-3):171-80</Citation><ArticleIdList><ArticleId IdType="pubmed">11325600</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2001 Jun 14;19(27):3681-91</Citation><ArticleIdList><ArticleId IdType="pubmed">11395202</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2001 Jul 15;167(2):623-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11441062</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Cytokine Netw. 2001 Oct-Dec;12(4):554-60</Citation><ArticleIdList><ArticleId IdType="pubmed">11781181</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2002 Aug;72(2):239-48</Citation><ArticleIdList><ArticleId IdType="pubmed">12149414</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Neurosci. 2002 Aug;3(8):655-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12154366</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2002 Aug 5;158(3):409-14</Citation><ArticleIdList><ArticleId IdType="pubmed">12163465</ArticleId></ArticleIdList></Reference><Reference><Citation>J Endotoxin Res. 2003;9(1):3-24</Citation><ArticleIdList><ArticleId IdType="pubmed">12691614</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatr Infect Dis J. 2004 Jan;23(1 Suppl):S87-97</Citation><ArticleIdList><ArticleId IdType="pubmed">14730275</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2004 Oct;4(10):812-23</Citation><ArticleIdList><ArticleId IdType="pubmed">15459672</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1981 Sep;144(3):225-31</Citation><ArticleIdList><ArticleId IdType="pubmed">6974206</ArticleId></ArticleIdList></Reference><Reference><Citation>J Lab Clin Med. 1985 Jan;105(1):124-31</Citation><ArticleIdList><ArticleId IdType="pubmed">3968461</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1986 Aug 8;233(4764):652-4</Citation><ArticleIdList><ArticleId IdType="pubmed">3014662</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Endocrinol. 1988 Dec;2(12):1256-64</Citation><ArticleIdList><ArticleId IdType="pubmed">3216865</ArticleId></ArticleIdList></Reference><Reference><Citation>Physiol Behav. 1989 Mar;45(3):591-4</Citation><ArticleIdList><ArticleId IdType="pubmed">2756050</ArticleId></ArticleIdList></Reference><Reference><Citation>J Steroid Biochem. 1989;34(1-6):235-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2560513</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Soc Nephrol. 1992 Jun;2(12 Suppl):S214-21</Citation><ArticleIdList><ArticleId IdType="pubmed">1323339</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Immunol. 1993;11:129-63</Citation><ArticleIdList><ArticleId IdType="pubmed">8476559</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neuroimmunol. 1994 Jan;49(1-2):25-33</Citation><ArticleIdList><ArticleId IdType="pubmed">8294561</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1994 Mar 24;368(6469):339-42</Citation><ArticleIdList><ArticleId IdType="pubmed">8127368</ArticleId></ArticleIdList></Reference><Reference><Citation>Brain Res. 1994 May 9;645(1-2):103-12</Citation><ArticleIdList><ArticleId IdType="pubmed">8062073</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 1995 Jun;63(6):2262-8</Citation><ArticleIdList><ArticleId IdType="pubmed">7768607</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 1997 Feb;9(1):35-43</Citation><ArticleIdList><ArticleId IdType="pubmed">9039774</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 1997 Mar;6(3):315-25</Citation><ArticleIdList><ArticleId IdType="pubmed">9075932</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 1997 Apr 7;185(7):1185-92</Citation><ArticleIdList><ArticleId IdType="pubmed">9104805</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1997 Jun 1;158(11):5297-304</Citation><ArticleIdList><ArticleId IdType="pubmed">9164949</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Rev. 1997 Aug;158:11-25</Citation><ArticleIdList><ArticleId IdType="pubmed">9314070</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol. 1998 Jan;274(1 Pt 1):G1-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9458766</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1998 Nov;72(11):8550-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9765393</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1998 Nov 15;161(10):5600-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9820538</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1999 Mar 15;162(6):3527-33</Citation><ArticleIdList><ArticleId IdType="pubmed">10092810</ArticleId></ArticleIdList></Reference><Reference><Citation>Pathol Int. 1999 Jun;49(6):519-32</Citation><ArticleIdList><ArticleId IdType="pubmed">10469395</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 1999 Oct;155(4):1391-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10514421</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Crit Care. 2005 Feb;11(1):29-36</Citation><ArticleIdList><ArticleId IdType="pubmed">15659942</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Immunol. 2005 Feb;35(2):524-32</Citation><ArticleIdList><ArticleId IdType="pubmed">15657949</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Mar;79(5):2880-90</Citation><ArticleIdList><ArticleId IdType="pubmed">15709007</ArticleId></ArticleIdList></Reference><Reference><Citation>Viral Immunol. 2005;18(1):41-78</Citation><ArticleIdList><ArticleId IdType="pubmed">15802953</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2005 Jul;86(Pt 7):1885-90</Citation><ArticleIdList><ArticleId IdType="pubmed">15958666</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2005 Sep;5(9):675-87</Citation><ArticleIdList><ArticleId IdType="pubmed">16110316</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2006 Apr;6(4):318-28</Citation><ArticleIdList><ArticleId IdType="pubmed">16557263</ArticleId></ArticleIdList></Reference><Reference><Citation>Tissue Antigens. 2006 Jul;68(1):1-12</Citation><ArticleIdList><ArticleId IdType="pubmed">16774534</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2006 Jul;19(3):571-82</Citation><ArticleIdList><ArticleId IdType="pubmed">16847087</ArticleId></ArticleIdList></Reference><Reference><Citation>Obesity (Silver Spring). 2006 Aug;14 Suppl 5:259S-265S</Citation><ArticleIdList><ArticleId IdType="pubmed">17021378</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasite Immunol. 2006 Nov;28(11):589-95</Citation><ArticleIdList><ArticleId IdType="pubmed">17042930</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15535-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17030789</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 2006 Nov 30;72(11):1529-37</Citation><ArticleIdList><ArticleId IdType="pubmed">16930562</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Cell Biol. 2007 Feb-Mar;85(2):85-92</Citation><ArticleIdList><ArticleId IdType="pubmed">17213831</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Microbiol Immunol. 2007 Jun;196(2):79-88</Citation><ArticleIdList><ArticleId IdType="pubmed">17136407</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2007 May 17;447(7142):326-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17507983</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Liver Dis. 2007 May;27(2):129-39</Citation><ArticleIdList><ArticleId IdType="pubmed">17520513</ArticleId></ArticleIdList></Reference><Reference><Citation>Autoimmun Rev. 2007 Nov;7(1):23-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17967721</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2008 Jan 20;370(2):310-22</Citation><ArticleIdList><ArticleId IdType="pubmed">17936870</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2008 Feb 18;205(2):323-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18227219</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2008 May 15;180(10):6846-53</Citation><ArticleIdList><ArticleId IdType="pubmed">18453605</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2008 May;14(5):558-64</Citation><ArticleIdList><ArticleId IdType="pubmed">18438414</ArticleId></ArticleIdList></Reference><Reference><Citation>J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):273-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18424036</ArticleId></ArticleIdList></Reference><Reference><Citation>Indian J Dermatol Venereol Leprol. 2008 May-Jun;74(3):194-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18583782</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2009 Jul;119(7):1910-20</Citation><ArticleIdList><ArticleId IdType="pubmed">19487810</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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