Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections.
Identifieur interne : 000424 ( PubMed/Corpus ); précédent : 000423; suivant : 000425Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections.
Auteurs : Amir Abd El Qader ; David Lieberman ; Yonat Shemer Avni ; Natali Svobodin ; Tsilia Lazarovitch ; Orli Sagi ; Yehuda ZeiriSource :
- Biomedical chromatography : BMC [ 1099-0801 ] ; 2015.
English descriptors
- KwdEn :
- Bacteria (metabolism), Bacterial Infections (microbiology), Biomarkers (analysis), Biomarkers (metabolism), Cyclohexanes (analysis), Cyclohexanes (metabolism), Gas Chromatography-Mass Spectrometry (methods), Heptanes (analysis), Heptanes (metabolism), Humans, Respiratory Tract Infections (microbiology), Respiratory Tract Infections (virology), Virus Diseases (virology), Viruses (metabolism), Volatile Organic Compounds (analysis), Volatile Organic Compounds (metabolism).
- MESH :
- chemical , analysis : Biomarkers, Cyclohexanes, Heptanes, Volatile Organic Compounds.
- metabolism : Bacteria, Biomarkers, Cyclohexanes, Heptanes, Viruses, Volatile Organic Compounds.
- methods : Gas Chromatography-Mass Spectrometry.
- microbiology : Bacterial Infections, Respiratory Tract Infections.
- virology : Respiratory Tract Infections, Virus Diseases.
- Humans.
Abstract
Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs. Two significant VOCs were identified as associated with infectious bacterial activity, heptane and methylcyclohexane. These two VOCs have been linked in previous studies to oxidative stress effects. In order to distinguish between bacterial and viral positive cultures, we performed principal component analysis including peak identity (retention time) and VOC concentration (i.e. area under the peak) revealing 1-hexanol and 1-heptadecene to be good predictors.
DOI: 10.1002/bmc.3494
PubMed: 26033043
Links to Exploration step
pubmed:26033043Le document en format XML
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<author><name sortKey="Lieberman, David" sort="Lieberman, David" uniqKey="Lieberman D" first="David" last="Lieberman">David Lieberman</name>
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<author><name sortKey="Shemer Avni, Yonat" sort="Shemer Avni, Yonat" uniqKey="Shemer Avni Y" first="Yonat" last="Shemer Avni">Yonat Shemer Avni</name>
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<term>Bacterial Infections (microbiology)</term>
<term>Biomarkers (analysis)</term>
<term>Biomarkers (metabolism)</term>
<term>Cyclohexanes (analysis)</term>
<term>Cyclohexanes (metabolism)</term>
<term>Gas Chromatography-Mass Spectrometry (methods)</term>
<term>Heptanes (analysis)</term>
<term>Heptanes (metabolism)</term>
<term>Humans</term>
<term>Respiratory Tract Infections (microbiology)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>Virus Diseases (virology)</term>
<term>Viruses (metabolism)</term>
<term>Volatile Organic Compounds (analysis)</term>
<term>Volatile Organic Compounds (metabolism)</term>
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<term>Cyclohexanes</term>
<term>Heptanes</term>
<term>Volatile Organic Compounds</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacteria</term>
<term>Biomarkers</term>
<term>Cyclohexanes</term>
<term>Heptanes</term>
<term>Viruses</term>
<term>Volatile Organic Compounds</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gas Chromatography-Mass Spectrometry</term>
</keywords>
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<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
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<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
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<front><div type="abstract" xml:lang="en">Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs. Two significant VOCs were identified as associated with infectious bacterial activity, heptane and methylcyclohexane. These two VOCs have been linked in previous studies to oxidative stress effects. In order to distinguish between bacterial and viral positive cultures, we performed principal component analysis including peak identity (retention time) and VOC concentration (i.e. area under the peak) revealing 1-hexanol and 1-heptadecene to be good predictors.</div>
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<Abstract><AbstractText>Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs. Two significant VOCs were identified as associated with infectious bacterial activity, heptane and methylcyclohexane. These two VOCs have been linked in previous studies to oxidative stress effects. In order to distinguish between bacterial and viral positive cultures, we performed principal component analysis including peak identity (retention time) and VOC concentration (i.e. area under the peak) revealing 1-hexanol and 1-heptadecene to be good predictors.</AbstractText>
<CopyrightInformation>Copyright © 2015 John Wiley & Sons, Ltd.</CopyrightInformation>
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<AffiliationInfo><Affiliation>Division of Chemistry, Nuclear Research Center, Negev, Beer-Sheva, Israel.</Affiliation>
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