Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.
Identifieur interne : 000423 ( PubMed/Corpus ); précédent : 000422; suivant : 000424Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.
Auteurs : Eike R. Hrincius ; Swantje Liedmann ; David Finkelstein ; Peter Vogel ; Shane Gansebom ; Amali E. Samarasinghe ; Dahui You ; Stephania A. Cormier ; Jonathan A. MccullersSource :
- Cell reports [ 2211-1247 ] ; 2015.
English descriptors
- KwdEn :
- Acute Lung Injury (immunology), Acute Lung Injury (metabolism), Acute Lung Injury (virology), Animals, Dogs, Endoplasmic Reticulum Stress (immunology), Glycosylation, HEK293 Cells, Humans, Immunity, Innate (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Influenza, Human (metabolism), Influenza, Human (virology), Madin Darby Canine Kidney Cells, Mice, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (metabolism), Orthomyxoviridae Infections (virology), Signal Transduction.
- MESH :
- immunology : Acute Lung Injury, Endoplasmic Reticulum Stress, Immunity, Innate, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Orthomyxoviridae Infections.
- metabolism : Acute Lung Injury, Influenza, Human, Orthomyxoviridae Infections.
- virology : Acute Lung Injury, Influenza, Human, Orthomyxoviridae Infections.
- Animals, Dogs, Glycosylation, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Mice, Signal Transduction.
Abstract
Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate "non-self" at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections.
DOI: 10.1016/j.celrep.2015.05.012
PubMed: 26051937
Links to Exploration step
pubmed:26051937Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.</title>
<author><name sortKey="Hrincius, Eike R" sort="Hrincius, Eike R" uniqKey="Hrincius E" first="Eike R" last="Hrincius">Eike R. Hrincius</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liedmann, Swantje" sort="Liedmann, Swantje" uniqKey="Liedmann S" first="Swantje" last="Liedmann">Swantje Liedmann</name>
<affiliation><nlm:affiliation>Institute of Molecular Virology (IMV), University of Muenster, Muenster 48149, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Finkelstein, David" sort="Finkelstein, David" uniqKey="Finkelstein D" first="David" last="Finkelstein">David Finkelstein</name>
<affiliation><nlm:affiliation>Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vogel, Peter" sort="Vogel, Peter" uniqKey="Vogel P" first="Peter" last="Vogel">Peter Vogel</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gansebom, Shane" sort="Gansebom, Shane" uniqKey="Gansebom S" first="Shane" last="Gansebom">Shane Gansebom</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E" last="Samarasinghe">Amali E. Samarasinghe</name>
<affiliation><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="You, Dahui" sort="You, Dahui" uniqKey="You D" first="Dahui" last="You">Dahui You</name>
<affiliation><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cormier, Stephania A" sort="Cormier, Stephania A" uniqKey="Cormier S" first="Stephania A" last="Cormier">Stephania A. Cormier</name>
<affiliation><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA. Electronic address: jmccullers@uthsc.edu.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26051937</idno>
<idno type="pmid">26051937</idno>
<idno type="doi">10.1016/j.celrep.2015.05.012</idno>
<idno type="wicri:Area/PubMed/Corpus">000423</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000423</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.</title>
<author><name sortKey="Hrincius, Eike R" sort="Hrincius, Eike R" uniqKey="Hrincius E" first="Eike R" last="Hrincius">Eike R. Hrincius</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liedmann, Swantje" sort="Liedmann, Swantje" uniqKey="Liedmann S" first="Swantje" last="Liedmann">Swantje Liedmann</name>
<affiliation><nlm:affiliation>Institute of Molecular Virology (IMV), University of Muenster, Muenster 48149, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Finkelstein, David" sort="Finkelstein, David" uniqKey="Finkelstein D" first="David" last="Finkelstein">David Finkelstein</name>
<affiliation><nlm:affiliation>Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vogel, Peter" sort="Vogel, Peter" uniqKey="Vogel P" first="Peter" last="Vogel">Peter Vogel</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gansebom, Shane" sort="Gansebom, Shane" uniqKey="Gansebom S" first="Shane" last="Gansebom">Shane Gansebom</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E" last="Samarasinghe">Amali E. Samarasinghe</name>
<affiliation><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="You, Dahui" sort="You, Dahui" uniqKey="You D" first="Dahui" last="You">Dahui You</name>
<affiliation><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cormier, Stephania A" sort="Cormier, Stephania A" uniqKey="Cormier S" first="Stephania A" last="Cormier">Stephania A. Cormier</name>
<affiliation><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA. Electronic address: jmccullers@uthsc.edu.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell reports</title>
<idno type="eISSN">2211-1247</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Lung Injury (immunology)</term>
<term>Acute Lung Injury (metabolism)</term>
<term>Acute Lung Injury (virology)</term>
<term>Animals</term>
<term>Dogs</term>
<term>Endoplasmic Reticulum Stress (immunology)</term>
<term>Glycosylation</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Immunity, Innate (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mice</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (metabolism)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acute Lung Injury</term>
<term>Endoplasmic Reticulum Stress</term>
<term>Immunity, Innate</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Lung Injury</term>
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Acute Lung Injury</term>
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dogs</term>
<term>Glycosylation</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mice</term>
<term>Signal Transduction</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate "non-self" at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26051937</PMID>
<DateCompleted><Year>2016</Year>
<Month>03</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-1247</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>10</Issue>
<PubDate><Year>2015</Year>
<Month>Jun</Month>
<Day>16</Day>
</PubDate>
</JournalIssue>
<Title>Cell reports</Title>
<ISOAbbreviation>Cell Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.</ArticleTitle>
<Pagination><MedlinePgn>1591-603</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.celrep.2015.05.012</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S2211-1247(15)00524-0</ELocationID>
<Abstract><AbstractText>Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate "non-self" at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections. </AbstractText>
<CopyrightInformation>Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hrincius</LastName>
<ForeName>Eike R</ForeName>
<Initials>ER</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liedmann</LastName>
<ForeName>Swantje</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology (IMV), University of Muenster, Muenster 48149, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Finkelstein</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vogel</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gansebom</LastName>
<ForeName>Shane</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samarasinghe</LastName>
<ForeName>Amali E</ForeName>
<Initials>AE</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>You</LastName>
<ForeName>Dahui</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cormier</LastName>
<ForeName>Stephania A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McCullers</LastName>
<ForeName>Jonathan A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA. Electronic address: jmccullers@uthsc.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>GEO</DataBankName>
<AccessionNumberList><AccessionNumber>GSE65075</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI090059</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01ES015050</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P42 ES013648</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P42ES013648</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES015050</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01AI090059</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>06</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Cell Rep</MedlineTA>
<NlmUniqueID>101573691</NlmUniqueID>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D055371" MajorTopicYN="N">Acute Lung Injury</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059865" MajorTopicYN="N">Endoplasmic Reticulum Stress</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006031" MajorTopicYN="N">Glycosylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061985" MajorTopicYN="N">Madin Darby Canine Kidney Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>09</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>01</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>05</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>6</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>6</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>3</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26051937</ArticleId>
<ArticleId IdType="pii">S2211-1247(15)00524-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.celrep.2015.05.012</ArticleId>
<ArticleId IdType="pmc">PMC4682876</ArticleId>
<ArticleId IdType="mid">NIHMS742887</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Immunol. 2013 Mar 1;190(5):2169-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23365085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Rev. 1992 Mar;56(1):152-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1579108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2013 Nov;5(11):2881-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24284879</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Jun;67(6):3048-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8497042</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2012 Jun 15;444(3):429-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22642577</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Enzymol. 2011;490:71-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21266244</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2003 Jan;11(1):79-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12535523</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2002 Jan;83(Pt 1):61-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11752701</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Aug;87(15):8756-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23740978</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods. 2001 Dec;25(4):402-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11846609</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Infect Dis. 2006;6:87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16725022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2012 Jun;180(6):2361-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22525464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Genes. 2014 Feb;48(1):189-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24174280</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Microbiol. 2010 Jun;12(6):831-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20088952</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2009;666:49-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20054974</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2014;6(3):1294-316</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24638204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 2013 Dec;94(6):1167-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23990626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Feb 10;287(7):4679-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22194594</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Protoc Cell Biol. 2010 Mar;Chapter 26:Unit26.6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20235102</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13622-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16174751</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Microbiol. 2014 May 16;5:222</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24904537</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Cell Mol Biol. 2012 May;46(5):573-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21799120</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12883005</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2014 Jun 13;344(6189):1218-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24925999</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yonsei Med J. 2012 Sep;53(5):886-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22869469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2013 Aug 1;191(3):1250-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23804714</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hepat Mon. 2013 Sep 07;13(9):e12280</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24282423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Genet Evol. 2011 Jul;11(5):997-1005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21457796</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2007 Feb 6;115(5):584-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17283277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbes Infect. 2010 Jan;12(1):81-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19782761</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Aug;81(16):8593-600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17553891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Comp Pathol. 2014 Jul;151(1):83-112</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24581932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2012;726:201-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22297515</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2013;3:1142</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23359618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013;8(4):e61397</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23637827</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Microbiol. 2014 May 20;5:233</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24904547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3166-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14963236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Immunol. 2007 Dec;125(3):328-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17827068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 Oct;83(20):10710-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19656891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cells. 2010 Dec;30(6):497-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21340671</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2014 Jul 15;59(2):166-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24785230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2009;4(1):44-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19131956</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anal Biochem. 1987 Apr;162(1):156-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2440339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18137-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19822741</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Immunol. 2011 Jul;48(12-13):1468-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21529952</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2014 Oct;1843(10):2150-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24440275</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2007;598:279-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17892219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mucosal Immunol. 2013 Jan;6(1):45-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22692455</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1981 Jan 29;289(5796):366-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7464906</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Res Vet Sci. 2007 Feb;82(1):115-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16759680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Genomics Hum Genet. 2006;7:103-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16722804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2013 May 29;5(187):187ra70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23720581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biostatistics. 2003 Apr;4(2):249-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12925520</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000423 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000423 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= StressCovidV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:26051937 |texte= Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26051937" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a StressCovidV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |