Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.
Identifieur interne : 000070 ( PubMed/Checkpoint ); précédent : 000069; suivant : 000071Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.
Auteurs : Milka Mileva [Bulgarie] ; Adriana Dimitrova [Bulgarie] ; Dimo Krastev [Bulgarie] ; Albena Alexandrova [Bulgarie] ; Elina Tsvetanova [Bulgarie] ; Almira Georgieva [Bulgarie] ; Angel Galabov [Bulgarie]Source :
- Drug research [ 2194-9387 ] ; 2020.
Abstract
The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.
DOI: 10.1055/a-1147-8824
PubMed: 32316058
Affiliations:
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<front><div type="abstract" xml:lang="en">The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.</div>
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<Month>04</Month>
<Day>21</Day>
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<Abstract><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">After inoculation of albino mice with 10 MLD<sub>50</sub>
of influenza virus A/Aichi/2/68 (H3N2), oseltamivir was applied twice a day, for five days post-infection in doses of 1.25 and 2.5 mg/kg. SAM was administered once a day for 10 days, starting 5 days before infection in doses of 50, 100 and 150 mg/kg.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Monotherapy with SAM did not influence the markers of oxidative stress in the lung. Combination of SAM 50 mg/kg and oseltamivir 2.5 mg/kg affected best the virological parameters - viral titer, protection index, and mean survival time, as well as the biochemical markers of oxidative stress.</AbstractText>
<AbstractText Label="INTERPRETATION AND CONCLUSIONS" NlmCategory="CONCLUSIONS">Combining of SAM and oseltamivir in a dose of 1/4 of optimal therapeutic could be considered as a perspective therapy of influenza viral infection.</AbstractText>
<CopyrightInformation>© Georg Thieme Verlag KG Stuttgart · New York.</CopyrightInformation>
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