Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.
Identifieur interne : 000048 ( PubMed/Corpus ); précédent : 000047; suivant : 000049Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.
Auteurs : Milka Mileva ; Adriana Dimitrova ; Dimo Krastev ; Albena Alexandrova ; Elina Tsvetanova ; Almira Georgieva ; Angel GalabovSource :
- Drug research [ 2194-9387 ] ; 2020.
Abstract
The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.
DOI: 10.1055/a-1147-8824
PubMed: 32316058
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.</title><author><name sortKey="Mileva, Milka" sort="Mileva, Milka" uniqKey="Mileva M" first="Milka" last="Mileva">Milka Mileva</name><affiliation><nlm:affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Dimitrova, Adriana" sort="Dimitrova, Adriana" uniqKey="Dimitrova A" first="Adriana" last="Dimitrova">Adriana Dimitrova</name><affiliation><nlm:affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Krastev, Dimo" sort="Krastev, Dimo" uniqKey="Krastev D" first="Dimo" last="Krastev">Dimo Krastev</name><affiliation><nlm:affiliation>Medical University of Sofia, Medical College, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Alexandrova, Albena" sort="Alexandrova, Albena" uniqKey="Alexandrova A" first="Albena" last="Alexandrova">Albena Alexandrova</name><affiliation><nlm:affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Tsvetanova, Elina" sort="Tsvetanova, Elina" uniqKey="Tsvetanova E" first="Elina" last="Tsvetanova">Elina Tsvetanova</name><affiliation><nlm:affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Georgieva, Almira" sort="Georgieva, Almira" uniqKey="Georgieva A" first="Almira" last="Georgieva">Almira Georgieva</name><affiliation><nlm:affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Galabov, Angel" sort="Galabov, Angel" uniqKey="Galabov A" first="Angel" last="Galabov">Angel Galabov</name><affiliation><nlm:affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32316058</idno><idno type="pmid">32316058</idno><idno type="doi">10.1055/a-1147-8824</idno><idno type="wicri:Area/PubMed/Corpus">000048</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000048</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.</title><author><name sortKey="Mileva, Milka" sort="Mileva, Milka" uniqKey="Mileva M" first="Milka" last="Mileva">Milka Mileva</name><affiliation><nlm:affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Dimitrova, Adriana" sort="Dimitrova, Adriana" uniqKey="Dimitrova A" first="Adriana" last="Dimitrova">Adriana Dimitrova</name><affiliation><nlm:affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Krastev, Dimo" sort="Krastev, Dimo" uniqKey="Krastev D" first="Dimo" last="Krastev">Dimo Krastev</name><affiliation><nlm:affiliation>Medical University of Sofia, Medical College, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Alexandrova, Albena" sort="Alexandrova, Albena" uniqKey="Alexandrova A" first="Albena" last="Alexandrova">Albena Alexandrova</name><affiliation><nlm:affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Tsvetanova, Elina" sort="Tsvetanova, Elina" uniqKey="Tsvetanova E" first="Elina" last="Tsvetanova">Elina Tsvetanova</name><affiliation><nlm:affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Georgieva, Almira" sort="Georgieva, Almira" uniqKey="Georgieva A" first="Almira" last="Georgieva">Almira Georgieva</name><affiliation><nlm:affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Galabov, Angel" sort="Galabov, Angel" uniqKey="Galabov A" first="Angel" last="Galabov">Angel Galabov</name><affiliation><nlm:affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Drug research</title><idno type="eISSN">2194-9387</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32316058</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2194-9387</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>21</Day></PubDate></JournalIssue><Title>Drug research</Title><ISOAbbreviation>Drug Res (Stuttg)</ISOAbbreviation></Journal><ArticleTitle>Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1055/a-1147-8824</ELocationID><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">After inoculation of albino mice with 10 MLD<sub>50</sub> of influenza virus A/Aichi/2/68 (H3N2), oseltamivir was applied twice a day, for five days post-infection in doses of 1.25 and 2.5 mg/kg. SAM was administered once a day for 10 days, starting 5 days before infection in doses of 50, 100 and 150 mg/kg.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Monotherapy with SAM did not influence the markers of oxidative stress in the lung. Combination of SAM 50 mg/kg and oseltamivir 2.5 mg/kg affected best the virological parameters - viral titer, protection index, and mean survival time, as well as the biochemical markers of oxidative stress.</AbstractText><AbstractText Label="INTERPRETATION AND CONCLUSIONS" NlmCategory="CONCLUSIONS">Combining of SAM and oseltamivir in a dose of 1/4 of optimal therapeutic could be considered as a perspective therapy of influenza viral infection.</AbstractText><CopyrightInformation>© Georg Thieme Verlag KG Stuttgart · New York.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="N"><LastName>Mileva</LastName><ForeName>Milka</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Dimitrova</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Krastev</LastName><ForeName>Dimo</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Medical University of Sofia, Medical College, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Alexandrova</LastName><ForeName>Albena</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Tsvetanova</LastName><ForeName>Elina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Georgieva</LastName><ForeName>Almira</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Galabov</LastName><ForeName>Angel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Drug Res (Stuttg)</MedlineTA><NlmUniqueID>101602406</NlmUniqueID><ISSNLinking>2194-9379</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CoiStatement>The authors declare that they have no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32316058</ArticleId><ArticleId IdType="doi">10.1055/a-1147-8824</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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