Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.
Identifieur interne : 000313 ( Ncbi/Merge ); précédent : 000312; suivant : 000314Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.
Auteurs : Barry Rockx [États-Unis] ; Tracey Baas ; Gregory A. Zornetzer ; Bart Haagmans ; Timothy Sheahan ; Matthew Frieman ; Matthew D. Dyer ; Thomas H. Teal ; Sean Proll ; Judith Van Den Brand ; Ralph Baric ; Michael G. KatzeSource :
- Journal of virology [ 1098-5514 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Cytokines (génétique), Cytokines (immunologie), Expression des gènes, Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (immunologie), Humains, Modèles animaux de maladie humaine, Mort, Poumon (anatomopathologie), Poumon (immunologie), Protéines de l'enveloppe virale (immunologie), Régulation positive, Souris, Souris de lignée BALB C, Syndrome de détresse respiratoire de l'adulte (génétique), Syndrome de détresse respiratoire de l'adulte (immunologie), Syndrome de détresse respiratoire de l'adulte (mortalité), Syndrome de détresse respiratoire de l'adulte (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Vieillissement (immunologie), Virus du SRAS (immunologie), Virus du SRAS (isolement et purification), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Poumon.
- génétique : Cytokines, Syndrome de détresse respiratoire de l'adulte, Syndrome respiratoire aigu sévère.
- immunologie : Cytokines, Glycoprotéines membranaires, Poumon, Protéines de l'enveloppe virale, Syndrome de détresse respiratoire de l'adulte, Syndrome respiratoire aigu sévère, Vieillissement, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- mortalité : Syndrome de détresse respiratoire de l'adulte.
- physiologie : Virus du SRAS.
- virologie : Syndrome de détresse respiratoire de l'adulte, Syndrome respiratoire aigu sévère.
- Animaux, Expression des gènes, Femelle, Glycoprotéine de spicule des coronavirus, Humains, Modèles animaux de maladie humaine, Mort, Régulation positive, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Aging (immunology), Animals, Cytokines (genetics), Cytokines (immunology), Death, Disease Models, Animal, Female, Gene Expression, Humans, Lung (immunology), Lung (pathology), Membrane Glycoproteins (immunology), Mice, Mice, Inbred BALB C, Respiratory Distress Syndrome, Adult (genetics), Respiratory Distress Syndrome, Adult (immunology), Respiratory Distress Syndrome, Adult (mortality), Respiratory Distress Syndrome, Adult (virology), SARS Virus (immunology), SARS Virus (isolation & purification), SARS Virus (physiology), Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Up-Regulation, Viral Envelope Proteins (immunology).
- MESH :
- chemical , genetics : Cytokines.
- complications : Severe Acute Respiratory Syndrome.
- genetics : Respiratory Distress Syndrome, Adult, Severe Acute Respiratory Syndrome.
- immunology : Aging, Cytokines, Lung, Membrane Glycoproteins, Respiratory Distress Syndrome, Adult, SARS Virus, Severe Acute Respiratory Syndrome, Viral Envelope Proteins.
- isolation & purification : SARS Virus.
- mortality : Respiratory Distress Syndrome, Adult.
- pathology : Lung.
- physiology : SARS Virus.
- virology : Respiratory Distress Syndrome, Adult, Severe Acute Respiratory Syndrome.
- Animals, Death, Disease Models, Animal, Female, Gene Expression, Humans, Mice, Mice, Inbred BALB C, Spike Glycoprotein, Coronavirus, Up-Regulation.
Abstract
Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied. Advanced age was significantly associated with increased SARS-related deaths, primarily due to the onset of early- and late-stage acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. Infection of aged, but not young, mice with recombinant viruses bearing spike glycoproteins derived from early human or palm civet isolates resulted in death accompanied by pathological changes associated with ARDS. In aged mice, a greater number of differentially expressed genes were observed than in young mice, whose responses were significantly delayed. Differences between lethal and nonlethal virus phenotypes in aged mice could be attributed to differences in host response kinetics rather than virus kinetics. SARS-CoV infection induced a range of interferon, cytokine, and pulmonary wound-healing genes, as well as several genes associated with the onset of ARDS. Mice that died also showed unique transcriptional profiles of immune response, apoptosis, cell cycle control, and stress. Cytokines associated with ARDS were significantly upregulated in animals experiencing lung pathology and lethal disease, while the same animals experienced downregulation of the ACE2 receptor. These data suggest that the magnitude and kinetics of a disproportionately strong host innate immune response contributed to severe respiratory stress and lethality. Although the molecular mechanisms governing ARDS pathophysiology remain unknown in aged animals, these studies reveal a strategy for dissecting the genetic pathways by which SARS-CoV infection induces changes in the host response, leading to death.
DOI: 10.1128/JVI.00127-09
PubMed: 19420084
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000745
- to stream PubMed, to step Curation: 000742
- to stream PubMed, to step Checkpoint: 000730
Links to Exploration step
pubmed:19420084Le document en format XML
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<term>Cytokines (immunology)</term>
<term>Death</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Lung (immunology)</term>
<term>Lung (pathology)</term>
<term>Membrane Glycoproteins (immunology)</term>
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<term>Mice, Inbred BALB C</term>
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<term>Respiratory Distress Syndrome, Adult (immunology)</term>
<term>Respiratory Distress Syndrome, Adult (mortality)</term>
<term>Respiratory Distress Syndrome, Adult (virology)</term>
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<term>Cytokines (immunologie)</term>
<term>Expression des gènes</term>
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<term>Glycoprotéines membranaires (immunologie)</term>
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<term>Modèles animaux de maladie humaine</term>
<term>Mort</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (immunologie)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Régulation positive</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied. Advanced age was significantly associated with increased SARS-related deaths, primarily due to the onset of early- and late-stage acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. Infection of aged, but not young, mice with recombinant viruses bearing spike glycoproteins derived from early human or palm civet isolates resulted in death accompanied by pathological changes associated with ARDS. In aged mice, a greater number of differentially expressed genes were observed than in young mice, whose responses were significantly delayed. Differences between lethal and nonlethal virus phenotypes in aged mice could be attributed to differences in host response kinetics rather than virus kinetics. SARS-CoV infection induced a range of interferon, cytokine, and pulmonary wound-healing genes, as well as several genes associated with the onset of ARDS. Mice that died also showed unique transcriptional profiles of immune response, apoptosis, cell cycle control, and stress. Cytokines associated with ARDS were significantly upregulated in animals experiencing lung pathology and lethal disease, while the same animals experienced downregulation of the ACE2 receptor. These data suggest that the magnitude and kinetics of a disproportionately strong host innate immune response contributed to severe respiratory stress and lethality. Although the molecular mechanisms governing ARDS pathophysiology remain unknown in aged animals, these studies reveal a strategy for dissecting the genetic pathways by which SARS-CoV infection induces changes in the host response, leading to death.</div>
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<Title>Journal of virology</Title>
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<ArticleTitle>Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.</ArticleTitle>
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<Abstract><AbstractText>Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied. Advanced age was significantly associated with increased SARS-related deaths, primarily due to the onset of early- and late-stage acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. Infection of aged, but not young, mice with recombinant viruses bearing spike glycoproteins derived from early human or palm civet isolates resulted in death accompanied by pathological changes associated with ARDS. In aged mice, a greater number of differentially expressed genes were observed than in young mice, whose responses were significantly delayed. Differences between lethal and nonlethal virus phenotypes in aged mice could be attributed to differences in host response kinetics rather than virus kinetics. SARS-CoV infection induced a range of interferon, cytokine, and pulmonary wound-healing genes, as well as several genes associated with the onset of ARDS. Mice that died also showed unique transcriptional profiles of immune response, apoptosis, cell cycle control, and stress. Cytokines associated with ARDS were significantly upregulated in animals experiencing lung pathology and lethal disease, while the same animals experienced downregulation of the ACE2 receptor. These data suggest that the magnitude and kinetics of a disproportionately strong host innate immune response contributed to severe respiratory stress and lethality. Although the molecular mechanisms governing ARDS pathophysiology remain unknown in aged animals, these studies reveal a strategy for dissecting the genetic pathways by which SARS-CoV infection induces changes in the host response, leading to death.</AbstractText>
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<ArticleId IdType="pmc">PMC2704758</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Intensive Care Med. 2005 Sep-Oct;20(5):302-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16206417</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16199517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Chem. 2005 Dec;51(12):2333-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16195357</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Dec;79(24):15511-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16306622</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2006 Apr 15;193(8):1078-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16544248</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Pharmacol. 2006 Jun;6(3):271-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16581295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2006 Jun;12(6):682-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16715088</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Pharm Des. 2006;12(24):3161-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16918441</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2006 Oct 5;443(7111):578-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17006449</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 2006 Nov;210(3):288-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17031779</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2006 Nov 1;174(9):1011-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16917113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Jan;81(2):991-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17079327</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Jan;81(2):548-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17108024</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Mar;81(5):2221-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17166899</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2007 Apr;170(4):1136-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17392154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Jul;81(14):7410-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17507479</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Aug;81(16):8692-706</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17537853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Sep;81(18):9812-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17596301</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2007 Aug 10;3(8):e112</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17696609</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2007 Oct;171(4):1215-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17717141</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Bioinformatics. 2007;8:290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17683603</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Jul 26;362(9380):263-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Apr;82(7):3220-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18199635</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2008 Apr;133(1):13-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17374415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2008 Apr;133(1):101-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17451827</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Oct;82(19):9465-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18632870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008 Dec;4(12):e1000240</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19079579</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Drug Targets. 2008 Feb;9(2):165-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18288968</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Formos Med Assoc. 1999 Nov;98(11):778-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10705696</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2000 May;25(1):25-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10802651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genet Res. 2001 Apr;77(2):123-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11355567</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2001 Dec;29(4):365-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11726920</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2002 Sep 1;166(5):646-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12204859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2002 Dec 1;100(12):4001-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12433697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 May 24;361(9371):1767-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 2003 Jul;200(3):282-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12845623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Travel Med. 2002 Nov-Dec;9(6):326-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12962589</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Pathol. 2003 Aug;34(8):743-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14506633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12995-3000</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14569023</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 Oct 30;425(6961):915</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14586458</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 2004 Feb;202(2):145-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14743496</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Apr;78(7):3572-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15016880</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respirology. 2003 Nov;8 Suppl:S9-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15018127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 2004 Jun;203(2):631-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15141377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Sep;78(17):9499-511</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15308742</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med J Aust. 1983 Apr 30;1(9):430-1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6835164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Immunol. 1990 Feb;79(2):151-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2311295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 1995 Apr;107(4):1062-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7705118</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Paediatr Child Health. 1999 Apr;35(2):207-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10365363</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L3-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15591040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jan;79(1):503-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15596843</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2005 Feb;75(2):185-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15602737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15657466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 May;79(9):5833-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15827197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2005 Jun;205:285-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15882361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2005 Apr 20;24(8):1634-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15791205</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2005 Jul 7;436(7047):112-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16001071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2005 Aug;11(8):875-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16007097</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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