StressCovidV1, Main, Merge, bibRecord, 002F46

Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers

Identifieur interne : 002F46 ( Main/Merge ); précédent : 002F45; suivant : 002F47

Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers

Auteurs : Shi-Jiang Li [États-Unis] ; Yonker Wang [États-Unis] ; John Pankiewicz [États-Unis] ; Elliot A. Stein [États-Unis]

Source :

Biological Psychiatry [ 0006-3223 ] ; 1999.

RBID : ISTEX:D70EFA9BCF79CC65D1C5ABCF3836DB2EAA93B029

English descriptors

Abstract

Abstract: Background: The aim of this study was to determine the existence of, and possible mechanisms for, chronic cocaine use-induced neurotoxicity in the human brain. Because in vivo magnetic resonance spectroscopy (MRS) provides a noninvasive way to detect biochemical and physiological changes in the brain, we sought to specifically determine the neurochemical adaptations in chronic cocaine-dependent subjects.Methods: Twenty-one cocaine users and 13 non–drug-using, age-matched normal volunteers were recruited for an in vivo proton MRS study. Following screening that included physical examination, histories, and blood testing, cocaine group subjects received a spectral scan on a 1.5-T GE Signa scanner. Spectra were obtained from the left basal ganglia and/or the left thalamus from subjects in both groups using an rf bird-cage type head coil with single-voxel localization.Results: The level of N-acetyl aspartate in the region of left thalamus was lower (17%) in the chronic cocaine user group but not in the region of left basal ganglia, compared with the control group.Conclusions: These results suggest that chronic cocaine use may induce abnormal neurochemical activity and a state of neuronal dysregulation and/or neurotoxicity. It will now be important to determine if these alterations are reversible during withdrawal and what the functional implications of this observation are with respect to cognitive function and drug relapse.

Url:

https://api.istex.fr/ark:/67375/6H6-V3MC1QM3-0/fulltext.pdf

DOI: 10.1016/S0006-3223(98)00230-3

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000780
to stream Istex, to step Curation: 000775
to stream Istex, to step Checkpoint: 001861

Links to Exploration step

ISTEX:D70EFA9BCF79CC65D1C5ABCF3836DB2EAA93B029

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers</title>
<author><name sortKey="Li, Shi Jiang" sort="Li, Shi Jiang" uniqKey="Li S" first="Shi-Jiang" last="Li">Shi-Jiang Li</name>
</author>
<author><name sortKey="Wang, Yonker" sort="Wang, Yonker" uniqKey="Wang Y" first="Yonker" last="Wang">Yonker Wang</name>
</author>
<author><name sortKey="Pankiewicz, John" sort="Pankiewicz, John" uniqKey="Pankiewicz J" first="John" last="Pankiewicz">John Pankiewicz</name>
</author>
<author><name sortKey="Stein, Elliot A" sort="Stein, Elliot A" uniqKey="Stein E" first="Elliot A" last="Stein">Elliot A. Stein</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D70EFA9BCF79CC65D1C5ABCF3836DB2EAA93B029</idno>
<date when="1999" year="1999">1999</date>
<idno type="doi">10.1016/S0006-3223(98)00230-3</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-V3MC1QM3-0/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000780</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000780</idno>
<idno type="wicri:Area/Istex/Curation">000775</idno>
<idno type="wicri:Area/Istex/Checkpoint">001861</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001861</idno>
<idno type="wicri:doubleKey">0006-3223:1999:Li S:neurochemical:adaptation:to</idno>
<idno type="wicri:Area/Main/Merge">002F46</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers</title>
<author><name sortKey="Li, Shi Jiang" sort="Li, Shi Jiang" uniqKey="Li S" first="Shi-Jiang" last="Li">Shi-Jiang Li</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biophysics Research Institute (SJL, YW, EAS), Medical College of Wisconsin, Milwaukee</wicri:regionArea>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Address reprint requests to Dr. Shi-Jiang Li, Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Yonker" sort="Wang, Yonker" uniqKey="Wang Y" first="Yonker" last="Wang">Yonker Wang</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biophysics Research Institute (SJL, YW, EAS), Medical College of Wisconsin, Milwaukee</wicri:regionArea>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pankiewicz, John" sort="Pankiewicz, John" uniqKey="Pankiewicz J" first="John" last="Pankiewicz">John Pankiewicz</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry (JP, EAS), Medical College of Wisconsin, Milwaukee</wicri:regionArea>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stein, Elliot A" sort="Stein, Elliot A" uniqKey="Stein E" first="Elliot A" last="Stein">Elliot A. Stein</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biophysics Research Institute (SJL, YW, EAS), Medical College of Wisconsin, Milwaukee</wicri:regionArea>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry (JP, EAS), Medical College of Wisconsin, Milwaukee</wicri:regionArea>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology (EAS), Medical College of Wisconsin, Milwaukee</wicri:regionArea>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Biological Psychiatry</title>
<title level="j" type="abbrev">BPS</title>
<idno type="ISSN">0006-3223</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1999">1999</date>
<biblScope unit="volume">45</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="1481">1481</biblScope>
<biblScope unit="page" to="1487">1487</biblScope>
</imprint>
<idno type="ISSN">0006-3223</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-3223</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>In vivo proton magnetic resonance spectroscopy</term>
<term>N-acetylaspartate</term>
<term>basal ganglia</term>
<term>cocaine</term>
<term>creatine</term>
<term>thalamus</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Abuser</term>
<term>Acute cocaine administration</term>
<term>Aids dementia</term>
<term>Anatomic localizer image</term>
<term>Basal</term>
<term>Basal ganglia</term>
<term>Biol</term>
<term>Biol psychiatry</term>
<term>Biophysics research institute</term>
<term>Cerebral atrophy</term>
<term>Cerebral metabolites</term>
<term>Cerebral vasculitis</term>
<term>Chronic cocaine</term>
<term>Chronic cocaine users</term>
<term>Cocaine</term>
<term>Cocaine abuse</term>
<term>Cocaine abusers</term>
<term>Cocaine addiction</term>
<term>Cocaine dependence</term>
<term>Cocaine group</term>
<term>Cocaine user</term>
<term>Cocaine users</term>
<term>Control group</term>
<term>Control subjects</term>
<term>Control volunteer</term>
<term>Detoxified subjects</term>
<term>Dopamine</term>
<term>Early withdrawal</term>
<term>Ganglion</term>
<term>Habitual cocaine abusers</term>
<term>Human brain</term>
<term>Imaging</term>
<term>Internal capsule</term>
<term>Localized</term>
<term>Localized proton</term>
<term>Magn</term>
<term>Magn reson</term>
<term>Magnetic resonance spectroscopic imaging</term>
<term>Magnetic resonance spectroscopy</term>
<term>Medical college</term>
<term>Metabolic</term>
<term>Metabolic concentrations</term>
<term>Metabolic ratios</term>
<term>Metabolism</term>
<term>Multiple sclerosis</term>
<term>Neurochemical</term>
<term>Neuron</term>
<term>Neuronal</term>
<term>Neuronal dysregulation</term>
<term>Neuronal loss</term>
<term>Neuronal viability</term>
<term>Neurosci biobehav</term>
<term>Normal control subjects</term>
<term>Normal volunteer</term>
<term>Polydrug abusers</term>
<term>Polysubstance abusers</term>
<term>Possible mechanisms</term>
<term>Present study</term>
<term>Proton</term>
<term>Psychiatry</term>
<term>Receptor availability</term>
<term>Reson</term>
<term>Resonance spectroscopy</term>
<term>Smrm meeting</term>
<term>Social phobia</term>
<term>Spectroscopy</term>
<term>Spgr images</term>
<term>Spgr surface coil image</term>
<term>Striatal dopaminergic responsiveness</term>
<term>Synaptic density</term>
<term>Thalamus</term>
<term>Tomography study</term>
<term>User</term>
<term>Vivo proton</term>
<term>Volkow</term>
<term>Water signal</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Background: The aim of this study was to determine the existence of, and possible mechanisms for, chronic cocaine use-induced neurotoxicity in the human brain. Because in vivo magnetic resonance spectroscopy (MRS) provides a noninvasive way to detect biochemical and physiological changes in the brain, we sought to specifically determine the neurochemical adaptations in chronic cocaine-dependent subjects.Methods: Twenty-one cocaine users and 13 non–drug-using, age-matched normal volunteers were recruited for an in vivo proton MRS study. Following screening that included physical examination, histories, and blood testing, cocaine group subjects received a spectral scan on a 1.5-T GE Signa scanner. Spectra were obtained from the left basal ganglia and/or the left thalamus from subjects in both groups using an rf bird-cage type head coil with single-voxel localization.Results: The level of N-acetyl aspartate in the region of left thalamus was lower (17%) in the chronic cocaine user group but not in the region of left basal ganglia, compared with the control group.Conclusions: These results suggest that chronic cocaine use may induce abnormal neurochemical activity and a state of neuronal dysregulation and/or neurotoxicity. It will now be important to determine if these alterations are reversible during withdrawal and what the functional implications of this observation are with respect to cognitive function and drug relapse.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F46 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002F46 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    StressCovidV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:D70EFA9BCF79CC65D1C5ABCF3836DB2EAA93B029
   |texte=   Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed May 6 16:44:09 2020. Site generation: Sun Mar 28 08:26:57 2021

	Serveur d'exploration Stress et Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Stress et Covid

Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers

Neurochemical adaptation to cocaine abuse: reduction of N-acetyl aspartate in thalamus of human cocaine abusers

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri