Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.
Identifieur interne : 001293 ( Main/Exploration ); précédent : 001292; suivant : 001294Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.
Auteurs : Hui-Juan Cao [République populaire de Chine] ; Rui-Rong Tan ; Rong-Rong He ; Lu-Ping Tang ; Xin-Luan Wang ; Nan Yao ; Wen-Jun Duan ; Yuan-Ao Hu ; Xin-Sheng Yao ; Hiroshi KuriharaSource :
- Evidence-based complementary and alternative medicine : eCAM [ 1741-4288 ] ; 2012.
Abstract
Sarcandra glabra, as a type of "antipyretic-detoxicate drugs", has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.
DOI: 10.1155/2012/236539
PubMed: 23227098
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000544
- to stream PubMed, to step Curation: 000542
- to stream PubMed, to step Checkpoint: 000554
- to stream Ncbi, to step Merge: 000554
- to stream Ncbi, to step Curation: 000554
- to stream Ncbi, to step Checkpoint: 000554
- to stream Main, to step Merge: 001295
- to stream Main, to step Curation: 001293
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.</title>
<author><name sortKey="Cao, Hui Juan" sort="Cao, Hui Juan" uniqKey="Cao H" first="Hui-Juan" last="Cao">Hui-Juan Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China ; Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China ; Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tan, Rui Rong" sort="Tan, Rui Rong" uniqKey="Tan R" first="Rui-Rong" last="Tan">Rui-Rong Tan</name>
</author>
<author><name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name>
</author>
<author><name sortKey="Tang, Lu Ping" sort="Tang, Lu Ping" uniqKey="Tang L" first="Lu-Ping" last="Tang">Lu-Ping Tang</name>
</author>
<author><name sortKey="Wang, Xin Luan" sort="Wang, Xin Luan" uniqKey="Wang X" first="Xin-Luan" last="Wang">Xin-Luan Wang</name>
</author>
<author><name sortKey="Yao, Nan" sort="Yao, Nan" uniqKey="Yao N" first="Nan" last="Yao">Nan Yao</name>
</author>
<author><name sortKey="Duan, Wen Jun" sort="Duan, Wen Jun" uniqKey="Duan W" first="Wen-Jun" last="Duan">Wen-Jun Duan</name>
</author>
<author><name sortKey="Hu, Yuan Ao" sort="Hu, Yuan Ao" uniqKey="Hu Y" first="Yuan-Ao" last="Hu">Yuan-Ao Hu</name>
</author>
<author><name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name>
</author>
<author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:23227098</idno>
<idno type="pmid">23227098</idno>
<idno type="doi">10.1155/2012/236539</idno>
<idno type="wicri:Area/PubMed/Corpus">000544</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000544</idno>
<idno type="wicri:Area/PubMed/Curation">000542</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000542</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000554</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000554</idno>
<idno type="wicri:Area/Ncbi/Merge">000554</idno>
<idno type="wicri:Area/Ncbi/Curation">000554</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000554</idno>
<idno type="wicri:Area/Main/Merge">001295</idno>
<idno type="wicri:Area/Main/Curation">001293</idno>
<idno type="wicri:Area/Main/Exploration">001293</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.</title>
<author><name sortKey="Cao, Hui Juan" sort="Cao, Hui Juan" uniqKey="Cao H" first="Hui-Juan" last="Cao">Hui-Juan Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China ; Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China ; Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tan, Rui Rong" sort="Tan, Rui Rong" uniqKey="Tan R" first="Rui-Rong" last="Tan">Rui-Rong Tan</name>
</author>
<author><name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name>
</author>
<author><name sortKey="Tang, Lu Ping" sort="Tang, Lu Ping" uniqKey="Tang L" first="Lu-Ping" last="Tang">Lu-Ping Tang</name>
</author>
<author><name sortKey="Wang, Xin Luan" sort="Wang, Xin Luan" uniqKey="Wang X" first="Xin-Luan" last="Wang">Xin-Luan Wang</name>
</author>
<author><name sortKey="Yao, Nan" sort="Yao, Nan" uniqKey="Yao N" first="Nan" last="Yao">Nan Yao</name>
</author>
<author><name sortKey="Duan, Wen Jun" sort="Duan, Wen Jun" uniqKey="Duan W" first="Wen-Jun" last="Duan">Wen-Jun Duan</name>
</author>
<author><name sortKey="Hu, Yuan Ao" sort="Hu, Yuan Ao" uniqKey="Hu Y" first="Yuan-Ao" last="Hu">Yuan-Ao Hu</name>
</author>
<author><name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name>
</author>
<author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name>
</author>
</analytic>
<series><title level="j">Evidence-based complementary and alternative medicine : eCAM</title>
<idno type="eISSN">1741-4288</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sarcandra glabra, as a type of "antipyretic-detoxicate drugs", has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Shenzhen</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Duan, Wen Jun" sort="Duan, Wen Jun" uniqKey="Duan W" first="Wen-Jun" last="Duan">Wen-Jun Duan</name>
<name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name>
<name sortKey="Hu, Yuan Ao" sort="Hu, Yuan Ao" uniqKey="Hu Y" first="Yuan-Ao" last="Hu">Yuan-Ao Hu</name>
<name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name>
<name sortKey="Tan, Rui Rong" sort="Tan, Rui Rong" uniqKey="Tan R" first="Rui-Rong" last="Tan">Rui-Rong Tan</name>
<name sortKey="Tang, Lu Ping" sort="Tang, Lu Ping" uniqKey="Tang L" first="Lu-Ping" last="Tang">Lu-Ping Tang</name>
<name sortKey="Wang, Xin Luan" sort="Wang, Xin Luan" uniqKey="Wang X" first="Xin-Luan" last="Wang">Xin-Luan Wang</name>
<name sortKey="Yao, Nan" sort="Yao, Nan" uniqKey="Yao N" first="Nan" last="Yao">Nan Yao</name>
<name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name>
</noCountry>
<country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Cao, Hui Juan" sort="Cao, Hui Juan" uniqKey="Cao H" first="Hui-Juan" last="Cao">Hui-Juan Cao</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001293 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001293 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= StressCovidV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:23227098 |texte= Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23227098" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a StressCovidV1
This area was generated with Dilib version V0.6.33. |