Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.
Identifieur interne : 000554 ( Ncbi/Merge ); précédent : 000553; suivant : 000555Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.
Auteurs : Hui-Juan Cao [République populaire de Chine] ; Rui-Rong Tan ; Rong-Rong He ; Lu-Ping Tang ; Xin-Luan Wang ; Nan Yao ; Wen-Jun Duan ; Yuan-Ao Hu ; Xin-Sheng Yao ; Hiroshi KuriharaSource :
- Evidence-based complementary and alternative medicine : eCAM [ 1741-4288 ] ; 2012.
Abstract
Sarcandra glabra, as a type of "antipyretic-detoxicate drugs", has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.
DOI: 10.1155/2012/236539
PubMed: 23227098
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Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China ; Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055</wicri:regionArea><placeName><settlement type="city">Shenzhen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Tan, Rui Rong" sort="Tan, Rui Rong" uniqKey="Tan R" first="Rui-Rong" last="Tan">Rui-Rong Tan</name></author><author><name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name></author><author><name sortKey="Tang, Lu Ping" sort="Tang, Lu Ping" uniqKey="Tang L" first="Lu-Ping" last="Tang">Lu-Ping Tang</name></author><author><name sortKey="Wang, Xin Luan" sort="Wang, Xin Luan" uniqKey="Wang X" first="Xin-Luan" last="Wang">Xin-Luan Wang</name></author><author><name sortKey="Yao, Nan" sort="Yao, Nan" uniqKey="Yao N" first="Nan" last="Yao">Nan Yao</name></author><author><name sortKey="Duan, Wen Jun" sort="Duan, Wen Jun" uniqKey="Duan W" first="Wen-Jun" last="Duan">Wen-Jun Duan</name></author><author><name sortKey="Hu, Yuan Ao" sort="Hu, Yuan Ao" uniqKey="Hu Y" first="Yuan-Ao" last="Hu">Yuan-Ao Hu</name></author><author><name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name></author><author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name></author></analytic><series><title level="j">Evidence-based complementary and alternative medicine : eCAM</title><idno type="eISSN">1741-4288</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sarcandra glabra, as a type of "antipyretic-detoxicate drugs", has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">23227098</PMID><DateCompleted><Year>2012</Year><Month>12</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1741-4288</ISSN><JournalIssue CitedMedium="Internet"><Volume>2012</Volume><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Evidence-based complementary and alternative medicine : eCAM</Title><ISOAbbreviation>Evid Based Complement Alternat Med</ISOAbbreviation></Journal><ArticleTitle>Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.</ArticleTitle><Pagination><MedlinePgn>236539</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2012/236539</ELocationID><Abstract><AbstractText>Sarcandra glabra, as a type of "antipyretic-detoxicate drugs", has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Hui-Juan</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China ; Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Rui-Rong</ForeName><Initials>RR</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Rong-Rong</ForeName><Initials>RR</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Lu-Ping</ForeName><Initials>LP</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xin-Luan</ForeName><Initials>XL</Initials></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Nan</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Wen-Jun</ForeName><Initials>WJ</Initials></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Yuan-Ao</ForeName><Initials>YA</Initials></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Xin-Sheng</ForeName><Initials>XS</Initials></Author><Author ValidYN="Y"><LastName>Kurihara</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Evid Based Complement Alternat Med</MedlineTA><NlmUniqueID>101215021</NlmUniqueID><ISSNLinking>1741-427X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>07</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>09</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23227098</ArticleId><ArticleId 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