Protective effect of apple polyphenols against stress-provoked influenza viral infection in restraint mice.
Identifieur interne : 001525 ( Main/Exploration ); précédent : 001524; suivant : 001526Protective effect of apple polyphenols against stress-provoked influenza viral infection in restraint mice.
Auteurs : Rong-Rong He [République populaire de Chine] ; Min Wang ; Cong-Zhi Wang ; Bang-Tian Chen ; Chun-Ni Lu ; Xin-Sheng Yao ; Jian-Xin Chen ; Hiroshi KuriharaSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Flavonoïdes (isolement et purification), Flavonoïdes (pharmacologie), Immobilisation, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Malus (), Mâle, Phénols (isolement et purification), Phénols (pharmacologie), Polyphénols, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (isolement et purification), Taux de survie.
- MESH :
- immunologie : Infections à Orthomyxoviridae.
- isolement et purification : Flavonoïdes, Phénols, Sous-type H1N1 du virus de la grippe A.
- pharmacologie : Flavonoïdes, Phénols.
- virologie : Infections à Orthomyxoviridae.
- Animaux, Immobilisation, Infections à Orthomyxoviridae, Malus, Mâle, Polyphénols, Souris, Souris de lignée BALB C, Taux de survie.
English descriptors
- KwdEn :
- Animals, Flavonoids (isolation & purification), Flavonoids (pharmacology), Immobilization, Influenza A Virus, H1N1 Subtype (isolation & purification), Male, Malus (chemistry), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Phenols (isolation & purification), Phenols (pharmacology), Polyphenols, Survival Rate.
- MESH :
- chemical , isolation & purification : Flavonoids, Phenols.
- chemical , pharmacology : Flavonoids, Phenols.
- chemistry : Malus.
- immunology : Orthomyxoviridae Infections.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- prevention & control : Orthomyxoviridae Infections.
- virology : Orthomyxoviridae Infections.
- Animals, Immobilization, Male, Mice, Mice, Inbred BALB C, Polyphenols, Survival Rate.
Abstract
This study was conducted to investigate the effects of apple polyphenol extract (APE) against influenza virus in mice loaded with restraint stress. The high-performance liquid chromatography (HPLC) fingerprint of APE was recorded, and the percentage composition of polyphenols was determined as 81.7%. Our results showed that restraint stress significantly promoted the mortality and duration of complications of mice infected with the H1N1 virus. However, oral administration of APE (100 and 200 mg/kg) improved the survival rates and prolonged living time of stressed mice infected with influenza virus in a dose-dependent manner. APE was further found to significantly improve the number of immunocytes, ratio of CD4 helper cells, secretion of IL-2, and capabilities of natural killer (NK) cytotoxicity (LU10/spleen) in spleens of restraint-stressed mice. In addition, APE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that the protective effects of APE on mice infected with influenza virus were related to the alleviation of stress-induced impairment of immune functions and its antioxidant property might contribute to the immune recovery.
DOI: 10.1021/jf104982y
PubMed: 21401102
Affiliations:
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Le document en format XML
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He</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Wang, Cong Zhi" sort="Wang, Cong Zhi" uniqKey="Wang C" first="Cong-Zhi" last="Wang">Cong-Zhi Wang</name></author><author><name sortKey="Chen, Bang Tian" sort="Chen, Bang Tian" uniqKey="Chen B" first="Bang-Tian" last="Chen">Bang-Tian Chen</name></author><author><name sortKey="Lu, Chun Ni" sort="Lu, Chun Ni" uniqKey="Lu C" first="Chun-Ni" last="Lu">Chun-Ni Lu</name></author><author><name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name></author><author><name sortKey="Chen, Jian Xin" sort="Chen, Jian Xin" uniqKey="Chen J" first="Jian-Xin" last="Chen">Jian-Xin Chen</name></author><author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Flavonoids (isolation & purification)</term><term>Flavonoids (pharmacology)</term><term>Immobilization</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Male</term><term>Malus (chemistry)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Orthomyxoviridae Infections (virology)</term><term>Phenols (isolation & purification)</term><term>Phenols (pharmacology)</term><term>Polyphenols</term><term>Survival Rate</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Flavonoïdes (isolement et purification)</term><term>Flavonoïdes (pharmacologie)</term><term>Immobilisation</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Malus ()</term><term>Mâle</term><term>Phénols (isolement et purification)</term><term>Phénols (pharmacologie)</term><term>Polyphénols</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Taux de survie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Flavonoids</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavonoids</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Malus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Flavonoïdes</term><term>Phénols</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Flavonoïdes</term><term>Phénols</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immobilization</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Polyphenols</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immobilisation</term><term>Infections à Orthomyxoviridae</term><term>Malus</term><term>Mâle</term><term>Polyphénols</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Taux de survie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was conducted to investigate the effects of apple polyphenol extract (APE) against influenza virus in mice loaded with restraint stress. The high-performance liquid chromatography (HPLC) fingerprint of APE was recorded, and the percentage composition of polyphenols was determined as 81.7%. Our results showed that restraint stress significantly promoted the mortality and duration of complications of mice infected with the H1N1 virus. However, oral administration of APE (100 and 200 mg/kg) improved the survival rates and prolonged living time of stressed mice infected with influenza virus in a dose-dependent manner. APE was further found to significantly improve the number of immunocytes, ratio of CD4 helper cells, secretion of IL-2, and capabilities of natural killer (NK) cytotoxicity (LU10/spleen) in spleens of restraint-stressed mice. In addition, APE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that the protective effects of APE on mice infected with influenza virus were related to the alleviation of stress-induced impairment of immune functions and its antioxidant property might contribute to the immune recovery.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><noCountry><name sortKey="Chen, Bang Tian" sort="Chen, Bang Tian" uniqKey="Chen B" first="Bang-Tian" last="Chen">Bang-Tian Chen</name><name sortKey="Chen, Jian Xin" sort="Chen, Jian Xin" uniqKey="Chen J" first="Jian-Xin" last="Chen">Jian-Xin Chen</name><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name><name sortKey="Lu, Chun Ni" sort="Lu, Chun Ni" uniqKey="Lu C" first="Chun-Ni" last="Lu">Chun-Ni Lu</name><name sortKey="Wang, Cong Zhi" sort="Wang, Cong Zhi" uniqKey="Wang C" first="Cong-Zhi" last="Wang">Cong-Zhi Wang</name><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name><name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name></noCountry><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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