Protective effect of apple polyphenols against stress-provoked influenza viral infection in restraint mice.
Identifieur interne : 000642 ( PubMed/Corpus ); précédent : 000641; suivant : 000643Protective effect of apple polyphenols against stress-provoked influenza viral infection in restraint mice.
Auteurs : Rong-Rong He ; Min Wang ; Cong-Zhi Wang ; Bang-Tian Chen ; Chun-Ni Lu ; Xin-Sheng Yao ; Jian-Xin Chen ; Hiroshi KuriharaSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Flavonoids (isolation & purification), Flavonoids (pharmacology), Immobilization, Influenza A Virus, H1N1 Subtype (isolation & purification), Male, Malus (chemistry), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Phenols (isolation & purification), Phenols (pharmacology), Polyphenols, Survival Rate.
- MESH :
- chemical , isolation & purification : Flavonoids, Phenols.
- chemical , pharmacology : Flavonoids, Phenols.
- chemistry : Malus.
- immunology : Orthomyxoviridae Infections.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- prevention & control : Orthomyxoviridae Infections.
- virology : Orthomyxoviridae Infections.
- Animals, Immobilization, Male, Mice, Mice, Inbred BALB C, Polyphenols, Survival Rate.
Abstract
This study was conducted to investigate the effects of apple polyphenol extract (APE) against influenza virus in mice loaded with restraint stress. The high-performance liquid chromatography (HPLC) fingerprint of APE was recorded, and the percentage composition of polyphenols was determined as 81.7%. Our results showed that restraint stress significantly promoted the mortality and duration of complications of mice infected with the H1N1 virus. However, oral administration of APE (100 and 200 mg/kg) improved the survival rates and prolonged living time of stressed mice infected with influenza virus in a dose-dependent manner. APE was further found to significantly improve the number of immunocytes, ratio of CD4 helper cells, secretion of IL-2, and capabilities of natural killer (NK) cytotoxicity (LU10/spleen) in spleens of restraint-stressed mice. In addition, APE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that the protective effects of APE on mice infected with influenza virus were related to the alleviation of stress-induced impairment of immune functions and its antioxidant property might contribute to the immune recovery.
DOI: 10.1021/jf104982y
PubMed: 21401102
Links to Exploration step
pubmed:21401102Le document en format XML
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sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name></author><author><name sortKey="Chen, Jian Xin" sort="Chen, Jian Xin" uniqKey="Chen J" first="Jian-Xin" last="Chen">Jian-Xin Chen</name></author><author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21401102</idno><idno type="pmid">21401102</idno><idno type="doi">10.1021/jf104982y</idno><idno type="wicri:Area/PubMed/Corpus">000642</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000642</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Protective effect of apple polyphenols against stress-provoked influenza viral infection in restraint mice.</title><author><name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Wang, Cong Zhi" sort="Wang, Cong Zhi" uniqKey="Wang C" first="Cong-Zhi" last="Wang">Cong-Zhi Wang</name></author><author><name sortKey="Chen, Bang Tian" sort="Chen, Bang Tian" uniqKey="Chen B" first="Bang-Tian" last="Chen">Bang-Tian Chen</name></author><author><name sortKey="Lu, Chun Ni" sort="Lu, Chun Ni" uniqKey="Lu C" first="Chun-Ni" last="Lu">Chun-Ni Lu</name></author><author><name sortKey="Yao, Xin Sheng" sort="Yao, Xin Sheng" uniqKey="Yao X" first="Xin-Sheng" last="Yao">Xin-Sheng Yao</name></author><author><name sortKey="Chen, Jian Xin" sort="Chen, Jian Xin" uniqKey="Chen J" first="Jian-Xin" last="Chen">Jian-Xin Chen</name></author><author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Flavonoids (isolation & purification)</term><term>Flavonoids (pharmacology)</term><term>Immobilization</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Male</term><term>Malus (chemistry)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Orthomyxoviridae Infections (virology)</term><term>Phenols (isolation & purification)</term><term>Phenols (pharmacology)</term><term>Polyphenols</term><term>Survival Rate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Flavonoids</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavonoids</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Malus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immobilization</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Polyphenols</term><term>Survival Rate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was conducted to investigate the effects of apple polyphenol extract (APE) against influenza virus in mice loaded with restraint stress. The high-performance liquid chromatography (HPLC) fingerprint of APE was recorded, and the percentage composition of polyphenols was determined as 81.7%. Our results showed that restraint stress significantly promoted the mortality and duration of complications of mice infected with the H1N1 virus. However, oral administration of APE (100 and 200 mg/kg) improved the survival rates and prolonged living time of stressed mice infected with influenza virus in a dose-dependent manner. APE was further found to significantly improve the number of immunocytes, ratio of CD4 helper cells, secretion of IL-2, and capabilities of natural killer (NK) cytotoxicity (LU10/spleen) in spleens of restraint-stressed mice. In addition, APE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that the protective effects of APE on mice infected with influenza virus were related to the alleviation of stress-induced impairment of immune functions and its antioxidant property might contribute to the immune recovery.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21401102</PMID><DateCompleted><Year>2011</Year><Month>08</Month><Day>17</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5118</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><Issue>8</Issue><PubDate><Year>2011</Year><Month>Apr</Month><Day>27</Day></PubDate></JournalIssue><Title>Journal of agricultural and food chemistry</Title><ISOAbbreviation>J. Agric. Food Chem.</ISOAbbreviation></Journal><ArticleTitle>Protective effect of apple polyphenols against stress-provoked influenza viral infection in restraint mice.</ArticleTitle><Pagination><MedlinePgn>3730-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jf104982y</ELocationID><Abstract><AbstractText>This study was conducted to investigate the effects of apple polyphenol extract (APE) against influenza virus in mice loaded with restraint stress. The high-performance liquid chromatography (HPLC) fingerprint of APE was recorded, and the percentage composition of polyphenols was determined as 81.7%. Our results showed that restraint stress significantly promoted the mortality and duration of complications of mice infected with the H1N1 virus. However, oral administration of APE (100 and 200 mg/kg) improved the survival rates and prolonged living time of stressed mice infected with influenza virus in a dose-dependent manner. APE was further found to significantly improve the number of immunocytes, ratio of CD4 helper cells, secretion of IL-2, and capabilities of natural killer (NK) cytotoxicity (LU10/spleen) in spleens of restraint-stressed mice. In addition, APE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that the protective effects of APE on mice infected with influenza virus were related to the alleviation of stress-induced impairment of immune functions and its antioxidant property might contribute to the immune recovery.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName><ForeName>Rong-Rong</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Min</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Cong-Zhi</ForeName><Initials>CZ</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Bang-Tian</ForeName><Initials>BT</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Chun-Ni</ForeName><Initials>CN</Initials></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Xin-Sheng</ForeName><Initials>XS</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jian-Xin</ForeName><Initials>JX</Initials></Author><Author ValidYN="Y"><LastName>Kurihara</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>03</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Agric Food Chem</MedlineTA><NlmUniqueID>0374755</NlmUniqueID><ISSNLinking>0021-8561</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D059808">Polyphenols</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007103" MajorTopicYN="Y">Immobilization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027845" MajorTopicYN="N">Malus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059808" MajorTopicYN="N">Polyphenols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21401102</ArticleId><ArticleId IdType="doi">10.1021/jf104982y</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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