Viral antibody dynamics in a chiropteran host
Identifieur interne : 001049 ( Main/Exploration ); précédent : 001048; suivant : 001050Viral antibody dynamics in a chiropteran host
Auteurs : Kate S. Baker ; Richard Suu-Ire ; Jennifer Barr ; David T. S. Hayman ; Christopher C. Broder ; Daniel L. Horton ; Christopher Durrant ; Pablo R. Murcia ; Andrew A. Cunningham ; James L. N. WoodSource :
- The Journal of Animal Ecology [ 0021-8790 ] ; 2013.
Abstract
Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated. In these, and other, systems, there is evidence that seasonal life‐cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts. To this end, we followed henipavirus antibody levels of >100 individual We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population‐level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period. The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half‐life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts.
Url:
DOI: 10.1111/1365-2656.12153
PubMed: 24111634
PubMed Central: 4413793
Affiliations:
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Baker</name><affiliation><nlm:aff id="jane12153-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jane12153-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="jane12153-curr-0001"></nlm:aff></affiliation></author><author><name sortKey="Suu Re, Richard" sort="Suu Re, Richard" uniqKey="Suu Re R" first="Richard" last="Suu-Ire">Richard Suu-Ire</name><affiliation><nlm:aff id="jane12153-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Barr, Jennifer" sort="Barr, Jennifer" uniqKey="Barr J" first="Jennifer" last="Barr">Jennifer Barr</name><affiliation><nlm:aff id="jane12153-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Hayman, David T S" sort="Hayman, David T S" uniqKey="Hayman D" first="David T. S." last="Hayman">David T. S. Hayman</name><affiliation><nlm:aff id="jane12153-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Broder, Christopher C" sort="Broder, Christopher C" uniqKey="Broder C" first="Christopher C." last="Broder">Christopher C. Broder</name><affiliation><nlm:aff id="jane12153-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Horton, Daniel L" sort="Horton, Daniel L" uniqKey="Horton D" first="Daniel L." last="Horton">Daniel L. Horton</name><affiliation><nlm:aff id="jane12153-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Durrant, Christopher" sort="Durrant, Christopher" uniqKey="Durrant C" first="Christopher" last="Durrant">Christopher Durrant</name><affiliation><nlm:aff id="jane12153-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Murcia, Pablo R" sort="Murcia, Pablo R" uniqKey="Murcia P" first="Pablo R." last="Murcia">Pablo R. Murcia</name><affiliation><nlm:aff id="jane12153-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Cunningham, Andrew A" sort="Cunningham, Andrew A" uniqKey="Cunningham A" first="Andrew A." last="Cunningham">Andrew A. Cunningham</name><affiliation><nlm:aff id="jane12153-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Wood, James L N" sort="Wood, James L N" uniqKey="Wood J" first="James L. N." last="Wood">James L. N. Wood</name><affiliation><nlm:aff id="jane12153-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Animal Ecology</title><idno type="ISSN">0021-8790</idno><idno type="eISSN">1365-2656</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p><list list-type="order" id="jane12153-list-0001"><list-item><p>Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated.</p></list-item><list-item><p>In these, and other, systems, there is evidence that seasonal life‐cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts.</p></list-item><list-item><p>To this end, we followed henipavirus antibody levels of >100 individual <italic>E. helvum</italic> in a closed, captive, breeding population over a 30‐month period, using a powerful novel antibody quantitation method.</p></list-item><list-item><p>We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population‐level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period.</p></list-item><list-item><p>The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half‐life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Delves, P J" uniqKey="Delves P">P.J. Delves</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baker, Kate S" sort="Baker, Kate S" uniqKey="Baker K" first="Kate S." last="Baker">Kate S. Baker</name><name sortKey="Barr, Jennifer" sort="Barr, Jennifer" uniqKey="Barr J" first="Jennifer" last="Barr">Jennifer Barr</name><name sortKey="Broder, Christopher C" sort="Broder, Christopher C" uniqKey="Broder C" first="Christopher C." last="Broder">Christopher C. Broder</name><name sortKey="Cunningham, Andrew A" sort="Cunningham, Andrew A" uniqKey="Cunningham A" first="Andrew A." last="Cunningham">Andrew A. Cunningham</name><name sortKey="Durrant, Christopher" sort="Durrant, Christopher" uniqKey="Durrant C" first="Christopher" last="Durrant">Christopher Durrant</name><name sortKey="Hayman, David T S" sort="Hayman, David T S" uniqKey="Hayman D" first="David T. S." last="Hayman">David T. S. Hayman</name><name sortKey="Horton, Daniel L" sort="Horton, Daniel L" uniqKey="Horton D" first="Daniel L." last="Horton">Daniel L. Horton</name><name sortKey="Murcia, Pablo R" sort="Murcia, Pablo R" uniqKey="Murcia P" first="Pablo R." last="Murcia">Pablo R. Murcia</name><name sortKey="Suu Re, Richard" sort="Suu Re, Richard" uniqKey="Suu Re R" first="Richard" last="Suu-Ire">Richard Suu-Ire</name><name sortKey="Wood, James L N" sort="Wood, James L N" uniqKey="Wood J" first="James L. N." last="Wood">James L. N. Wood</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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