Viral antibody dynamics in a chiropteran host
Identifieur interne : 000698 ( Pmc/Curation ); précédent : 000697; suivant : 000699Viral antibody dynamics in a chiropteran host
Auteurs : Kate S. Baker ; Richard Suu-Ire ; Jennifer Barr ; David T. S. Hayman ; Christopher C. Broder ; Daniel L. Horton ; Christopher Durrant ; Pablo R. Murcia ; Andrew A. Cunningham ; James L. N. WoodSource :
- The Journal of Animal Ecology [ 0021-8790 ] ; 2013.
Abstract
Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated. In these, and other, systems, there is evidence that seasonal life‐cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts. To this end, we followed henipavirus antibody levels of >100 individual We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population‐level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period. The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half‐life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts.
Url:
DOI: 10.1111/1365-2656.12153
PubMed: 24111634
PubMed Central: 4413793
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Baker</name><affiliation><nlm:aff id="jane12153-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jane12153-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="jane12153-curr-0001"></nlm:aff></affiliation></author><author><name sortKey="Suu Re, Richard" sort="Suu Re, Richard" uniqKey="Suu Re R" first="Richard" last="Suu-Ire">Richard Suu-Ire</name><affiliation><nlm:aff id="jane12153-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Barr, Jennifer" sort="Barr, Jennifer" uniqKey="Barr J" first="Jennifer" last="Barr">Jennifer Barr</name><affiliation><nlm:aff id="jane12153-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Hayman, David T S" sort="Hayman, David T S" uniqKey="Hayman D" first="David T. S." last="Hayman">David T. S. Hayman</name><affiliation><nlm:aff id="jane12153-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Broder, Christopher C" sort="Broder, Christopher C" uniqKey="Broder C" first="Christopher C." last="Broder">Christopher C. Broder</name><affiliation><nlm:aff id="jane12153-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Horton, Daniel L" sort="Horton, Daniel L" uniqKey="Horton D" first="Daniel L." last="Horton">Daniel L. Horton</name><affiliation><nlm:aff id="jane12153-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Durrant, Christopher" sort="Durrant, Christopher" uniqKey="Durrant C" first="Christopher" last="Durrant">Christopher Durrant</name><affiliation><nlm:aff id="jane12153-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Murcia, Pablo R" sort="Murcia, Pablo R" uniqKey="Murcia P" first="Pablo R." last="Murcia">Pablo R. Murcia</name><affiliation><nlm:aff id="jane12153-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Cunningham, Andrew A" sort="Cunningham, Andrew A" uniqKey="Cunningham A" first="Andrew A." last="Cunningham">Andrew A. Cunningham</name><affiliation><nlm:aff id="jane12153-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Wood, James L N" sort="Wood, James L N" uniqKey="Wood J" first="James L. N." last="Wood">James L. N. Wood</name><affiliation><nlm:aff id="jane12153-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Animal Ecology</title><idno type="ISSN">0021-8790</idno><idno type="eISSN">1365-2656</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p><list list-type="order" id="jane12153-list-0001"><list-item><p>Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated.</p></list-item><list-item><p>In these, and other, systems, there is evidence that seasonal life‐cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts.</p></list-item><list-item><p>To this end, we followed henipavirus antibody levels of >100 individual <italic>E. helvum</italic> in a closed, captive, breeding population over a 30‐month period, using a powerful novel antibody quantitation method.</p></list-item><list-item><p>We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population‐level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period.</p></list-item><list-item><p>The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half‐life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Delves, P J" uniqKey="Delves P">P.J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Anim Ecol</journal-id><journal-id journal-id-type="iso-abbrev">J Anim Ecol</journal-id><journal-id journal-id-type="doi">10.1111/(ISSN)1365-2656</journal-id><journal-id journal-id-type="publisher-id">JANE</journal-id><journal-title-group><journal-title>The Journal of Animal Ecology</journal-title></journal-title-group><issn pub-type="ppub">0021-8790</issn><issn pub-type="epub">1365-2656</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24111634</article-id><article-id pub-id-type="pmc">4413793</article-id><article-id pub-id-type="doi">10.1111/1365-2656.12153</article-id><article-id pub-id-type="publisher-id">JANE12153</article-id><article-categories><subj-group subj-group-type="overline"><subject>Standard Paper</subject></subj-group><subj-group subj-group-type="heading"><subject>Parasite and Disease Ecology</subject></subj-group></article-categories><title-group><article-title>Viral antibody dynamics in a chiropteran host</article-title><alt-title alt-title-type="left-running-head">K. S. Baker et al.</alt-title></title-group><contrib-group><contrib id="jane12153-cr-0001" contrib-type="author" corresp="yes"><name><surname>Baker</surname><given-names>Kate S.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0001"><sup>1</sup></xref><xref ref-type="aff" rid="jane12153-aff-0002"><sup>2</sup></xref><xref ref-type="aff" rid="jane12153-curr-0001"><sup>9</sup></xref></contrib><contrib id="jane12153-cr-0002" contrib-type="author"><name><surname>Suu‐Ire</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="jane12153-aff-0003"><sup>3</sup></xref></contrib><contrib id="jane12153-cr-0003" contrib-type="author"><name><surname>Barr</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="jane12153-aff-0004"><sup>4</sup></xref></contrib><contrib id="jane12153-cr-0004" contrib-type="author"><name><surname>Hayman</surname><given-names>David T. S.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0005"><sup>5</sup></xref></contrib><contrib id="jane12153-cr-0005" contrib-type="author"><name><surname>Broder</surname><given-names>Christopher C.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0006"><sup>6</sup></xref></contrib><contrib id="jane12153-cr-0006" contrib-type="author"><name><surname>Horton</surname><given-names>Daniel L.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0007"><sup>7</sup></xref></contrib><contrib id="jane12153-cr-0007" contrib-type="author"><name><surname>Durrant</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="jane12153-aff-0002"><sup>2</sup></xref></contrib><contrib id="jane12153-cr-0008" contrib-type="author"><name><surname>Murcia</surname><given-names>Pablo R.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0008"><sup>8</sup></xref></contrib><contrib id="jane12153-cr-0009" contrib-type="author" corresp="yes"><name><surname>Cunningham</surname><given-names>Andrew A.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0002"><sup>2</sup></xref></contrib><contrib id="jane12153-cr-0010" contrib-type="author"><name><surname>Wood</surname><given-names>James L. N.</given-names></name><xref ref-type="aff" rid="jane12153-aff-0001"><sup>1</sup></xref></contrib></contrib-group><contrib-group><contrib id="jane12153-cr-0011" contrib-type="editor"><name><surname>Boots</surname><given-names>Mike</given-names></name></contrib></contrib-group><aff id="jane12153-aff-0001"><label><sup>1</sup></label><named-content content-type="organisation-division">Disease Dynamics Unit</named-content><institution>University of Cambridge</institution><city>Cambridge</city><country country="GB">UK</country><postal-code>CB3 0ES</postal-code></aff><aff id="jane12153-aff-0002"><label><sup>2</sup></label><named-content content-type="organisation-division">Institute of Zoology</named-content><institution>Zoological Society of London</institution><city>London</city><country country="GB">UK</country><postal-code>NW1 4RY</postal-code></aff><aff id="jane12153-aff-0003"><label><sup>3</sup></label><named-content content-type="organisation-division">Wildlife Division</named-content><institution>Forestries Commission</institution><city>Accra</city><country country="GH">Ghana</country><postal-code>PO Box 239</postal-code></aff><aff id="jane12153-aff-0004"><label><sup>4</sup></label><named-content content-type="organisation-division">Australian Animal Health Laboratories</named-content><institution>Commonwealth Scientific and Industrial Research Organisation</institution><city>Geelong</city><named-content content-type="country-part">Vic</named-content><country country="AU">Australia</country><postal-code>3219</postal-code></aff><aff id="jane12153-aff-0005"><label><sup>5</sup></label><named-content content-type="organisation-division">Department of Biology</named-content><institution>Colorado State University</institution><city>Fort Collins</city><named-content content-type="country-part">CO</named-content><country country="US">USA</country><postal-code>80523</postal-code></aff><aff id="jane12153-aff-0006"><label><sup>6</sup></label><named-content content-type="organisation-division">Department of Microbiology and Immunology</named-content><institution>Uniformed Services University of the Health Sciences</institution><city>Bethesda</city><named-content content-type="country-part">MD</named-content><country country="US">USA</country><postal-code>20814‐4799</postal-code></aff><aff id="jane12153-aff-0007"><label><sup>7</sup></label><named-content content-type="organisation-division">Wildlife Zoonoses and Vector‐Borne Diseases Research Group</named-content><institution>Animal Health and Veterinary Laboratories Agency</institution><city>Surrey</city><country country="GB">UK</country><postal-code>KT15 3NB</postal-code></aff><aff id="jane12153-aff-0008"><label><sup>8</sup></label><named-content content-type="organisation-division">College of Medical</named-content><named-content content-type="organisation-division">Veterinary and Life Sciences</named-content><institution>University of Glasgow</institution><city>Glasgow</city><country country="GB">UK</country><postal-code>G12 8QQ</postal-code></aff><aff id="jane12153-curr-0001"><label><sup>9</sup></label>Present address:<institution>Wellcome Trust Sanger Institute</institution><named-content content-type="street">Hinxton</named-content><city>Cambridge</city><country country="GB">UK</country><postal-code>CB10 1SA</postal-code></aff><author-notes><corresp id="correspondenceTo"><label>*</label>Correspondence author: E‐mails: <email>kate.s.baker@gmail.com</email>; <email>a.cunningham@ioz.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2013</year></pub-date><volume>83</volume><issue>2</issue><issue-id pub-id-type="doi">10.1111/jane.2014.83.issue-2</issue-id><fpage>415</fpage><lpage>428</lpage><history><date date-type="received"><day>28</day><month>2</month><year>2013</year></date><date date-type="accepted"><day>14</day><month>9</month><year>2013</year></date></history><permissions><pmc-comment> © 2014 British Ecological Society </pmc-comment>
<copyright-statement content-type="article-copyright">© 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society</copyright-statement><license license-type="creativeCommonsBy"><license-p>This is an open access article under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="file:JANE-83-415.pdf"></self-uri><abstract id="jane12153-abs-0001"><title>Summary</title><p><list list-type="order" id="jane12153-list-0001"><list-item><p>Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated.</p></list-item><list-item><p>In these, and other, systems, there is evidence that seasonal life‐cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts.</p></list-item><list-item><p>To this end, we followed henipavirus antibody levels of >100 individual <italic>E. helvum</italic> in a closed, captive, breeding population over a 30‐month period, using a powerful novel antibody quantitation method.</p></list-item><list-item><p>We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population‐level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period.</p></list-item><list-item><p>The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half‐life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts.</p></list-item></list></p></abstract><abstract abstract-type="graphical" id="jane12153-abs-0002"><p>This is the first study of henipaviral infection dynamics in a fully closed population of the natural reservoir hosts. The authors detect population‐level infection persistence as well as increased periods of viral transmission related to life‐cycle events. These data help us to understand the seasonality of recurrent zoonotic spillovers of viruses from bat populations.
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