StressCovidV1, Main, Exploration, bibRecord, 003B64

Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.

Identifieur interne : 003B64 ( Main/Exploration ); précédent : 003B63; suivant : 003B65

Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.

Auteurs : M. Mileva [Bulgarie] ; V. Hadjimitova ; L. Tantcheva ; T. Traykov ; A S Galabov ; V. Savov ; S. Ribarov

Source :

Zeitschrift fur Naturforschung. C, Journal of biosciences [ 0939-5075 ]

RBID : pubmed:11098838

Descripteurs français

KwdFr :
- Animaux, Antioxydants (pharmacologie), Infections à Orthomyxoviridae (physiopathologie), Infections à Orthomyxoviridae (sang), Mâle, Peroxydation lipidique (), Piégeurs de radicaux libres (pharmacologie), Poumon (), Poumon (physiologie), Poumon (physiopathologie), Rat Wistar, Rats, Rimantadine (pharmacologie), Souris, Souris de lignée ICR, Substances réactives à l'acide thiobarbiturique (analyse), Superoxydes (métabolisme), Virus de la grippe A, Xanthine, Xanthine oxidase.
MESH :
- analyse : Substances réactives à l'acide thiobarbiturique.
- métabolisme : Superoxydes.
- pharmacologie : Antioxydants, Piégeurs de radicaux libres, Rimantadine.
- physiologie : Poumon.
- physiopathologie : Infections à Orthomyxoviridae, Poumon.
- sang : Infections à Orthomyxoviridae.
- Animaux, Mâle, Peroxydation lipidique, Poumon, Rat Wistar, Rats, Souris, Souris de lignée ICR, Virus de la grippe A, Xanthine, Xanthine oxidase.

English descriptors

KwdEn :
- Animals, Antioxidants (pharmacology), Free Radical Scavengers (pharmacology), Influenza A virus, Lipid Peroxidation (drug effects), Lung (drug effects), Lung (physiology), Lung (physiopathology), Male, Mice, Mice, Inbred ICR, Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (physiopathology), Rats, Rats, Wistar, Rimantadine (pharmacology), Superoxides (metabolism), Thiobarbituric Acid Reactive Substances (analysis), Xanthine, Xanthine Oxidase.
MESH :
- chemical , analysis : Thiobarbituric Acid Reactive Substances.
- chemical , metabolism : Superoxides.
- chemical , pharmacology : Antioxidants, Free Radical Scavengers, Rimantadine.
- blood : Orthomyxoviridae Infections.
- drug effects : Lipid Peroxidation, Lung.
- physiology : Lung.
- physiopathology : Lung, Orthomyxoviridae Infections.
- Animals, Influenza A virus, Male, Mice, Mice, Inbred ICR, Rats, Rats, Wistar, Xanthine, Xanthine Oxidase.

Abstract

Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe2+ and (Fe2+ - EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.

DOI: 10.1515/znc-2000-9-1025
PubMed: 11098838

Affiliations:

Bulgarie

Le document en format XML

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<term>Lung (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe2+ and (Fe2+ - EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.</div>
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Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.

Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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