Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.
Identifieur interne : 000A11 ( PubMed/Corpus ); précédent : 000A10; suivant : 000A12Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.
Auteurs : M. Mileva ; V. Hadjimitova ; L. Tantcheva ; T. Traykov ; A S Galabov ; V. Savov ; S. RibarovSource :
- Zeitschrift fur Naturforschung. C, Journal of biosciences [ 0939-5075 ]
English descriptors
- KwdEn :
- Animals, Antioxidants (pharmacology), Free Radical Scavengers (pharmacology), Influenza A virus, Lipid Peroxidation (drug effects), Lung (drug effects), Lung (physiology), Lung (physiopathology), Male, Mice, Mice, Inbred ICR, Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (physiopathology), Rats, Rats, Wistar, Rimantadine (pharmacology), Superoxides (metabolism), Thiobarbituric Acid Reactive Substances (analysis), Xanthine, Xanthine Oxidase.
- MESH :
- chemical , analysis : Thiobarbituric Acid Reactive Substances.
- chemical , metabolism : Superoxides.
- chemical , pharmacology : Antioxidants, Free Radical Scavengers, Rimantadine.
- blood : Orthomyxoviridae Infections.
- drug effects : Lipid Peroxidation, Lung.
- physiology : Lung.
- physiopathology : Lung, Orthomyxoviridae Infections.
- Animals, Influenza A virus, Male, Mice, Mice, Inbred ICR, Rats, Rats, Wistar, Xanthine, Xanthine Oxidase.
Abstract
Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe2+ and (Fe2+ - EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.
DOI: 10.1515/znc-2000-9-1025
PubMed: 11098838
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pubmed:11098838Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.</title><author><name sortKey="Mileva, M" sort="Mileva, M" uniqKey="Mileva M" first="M" last="Mileva">M. Mileva</name><affiliation><nlm:affiliation>Department of Biophysics, Sofia University School of Medicine. mileva@medfac.acad.bg</nlm:affiliation></affiliation></author><author><name sortKey="Hadjimitova, V" sort="Hadjimitova, V" uniqKey="Hadjimitova V" first="V" last="Hadjimitova">V. Hadjimitova</name></author><author><name sortKey="Tantcheva, L" sort="Tantcheva, L" uniqKey="Tantcheva L" first="L" last="Tantcheva">L. Tantcheva</name></author><author><name sortKey="Traykov, T" sort="Traykov, T" uniqKey="Traykov T" first="T" last="Traykov">T. Traykov</name></author><author><name sortKey="Galabov, A S" sort="Galabov, A S" uniqKey="Galabov A" first="A S" last="Galabov">A S Galabov</name></author><author><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name></author><author><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. Ribarov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2000 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:11098838</idno><idno type="pmid">11098838</idno><idno type="doi">10.1515/znc-2000-9-1025</idno><idno type="wicri:Area/PubMed/Corpus">000A11</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.</title><author><name sortKey="Mileva, M" sort="Mileva, M" uniqKey="Mileva M" first="M" last="Mileva">M. Mileva</name><affiliation><nlm:affiliation>Department of Biophysics, Sofia University School of Medicine. mileva@medfac.acad.bg</nlm:affiliation></affiliation></author><author><name sortKey="Hadjimitova, V" sort="Hadjimitova, V" uniqKey="Hadjimitova V" first="V" last="Hadjimitova">V. Hadjimitova</name></author><author><name sortKey="Tantcheva, L" sort="Tantcheva, L" uniqKey="Tantcheva L" first="L" last="Tantcheva">L. Tantcheva</name></author><author><name sortKey="Traykov, T" sort="Traykov, T" uniqKey="Traykov T" first="T" last="Traykov">T. Traykov</name></author><author><name sortKey="Galabov, A S" sort="Galabov, A S" uniqKey="Galabov A" first="A S" last="Galabov">A S Galabov</name></author><author><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name></author><author><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. Ribarov</name></author></analytic><series><title level="j">Zeitschrift fur Naturforschung. C, Journal of biosciences</title><idno type="ISSN">0939-5075</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antioxidants (pharmacology)</term><term>Free Radical Scavengers (pharmacology)</term><term>Influenza A virus</term><term>Lipid Peroxidation (drug effects)</term><term>Lung (drug effects)</term><term>Lung (physiology)</term><term>Lung (physiopathology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred ICR</term><term>Orthomyxoviridae Infections (blood)</term><term>Orthomyxoviridae Infections (physiopathology)</term><term>Rats</term><term>Rats, Wistar</term><term>Rimantadine (pharmacology)</term><term>Superoxides (metabolism)</term><term>Thiobarbituric Acid Reactive Substances (analysis)</term><term>Xanthine</term><term>Xanthine Oxidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Thiobarbituric Acid Reactive Substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Superoxides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Free Radical Scavengers</term><term>Rimantadine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lipid Peroxidation</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Influenza A virus</term><term>Male</term><term>Mice</term><term>Mice, Inbred ICR</term><term>Rats</term><term>Rats, Wistar</term><term>Xanthine</term><term>Xanthine Oxidase</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe2+ and (Fe2+ - EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11098838</PMID><DateCompleted><Year>2001</Year><Month>03</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0939-5075</ISSN><JournalIssue CitedMedium="Print"><Volume>55</Volume><Issue>9-10</Issue><PubDate><MedlineDate>2000 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Zeitschrift fur Naturforschung. C, Journal of biosciences</Title><ISOAbbreviation>Z. Naturforsch., C, J. Biosci.</ISOAbbreviation></Journal><ArticleTitle>Antioxidant properties of rimantadine in influenza virus infected mice and in some model systems.</ArticleTitle><Pagination><MedlinePgn>824-9</MedlinePgn></Pagination><Abstract><AbstractText>Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe2+ and (Fe2+ - EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mileva</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biophysics, Sofia University School of Medicine. mileva@medfac.acad.bg</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hadjimitova</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Tantcheva</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Traykov</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Galabov</LastName><ForeName>A S</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Savov</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ribarov</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Z Naturforsch C J Biosci</MedlineTA><NlmUniqueID>8912155</NlmUniqueID><ISSNLinking>0341-0382</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016166">Free Radical Scavengers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017392">Thiobarbituric Acid Reactive Substances</NameOfSubstance></Chemical><Chemical><RegistryNumber>0T2EF4JQTU</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Influenza A virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008813" MajorTopicYN="N">Mice, Inbred ICR</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000097" 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