Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.
Identifieur interne : 001802 ( Main/Exploration ); précédent : 001801; suivant : 001803Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.
Auteurs : Li Zhang [République populaire de Chine] ; Yong-Xian Cheng ; Ai-Lin Liu ; Hai-Di Wang ; Ya-Ling Wang ; Guan-Hua DuSource :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2010.
Descripteurs français
- KwdFr :
- Activation enzymatique (), Animaux, Anti-inflammatoires (), Anti-inflammatoires (pharmacologie), Antioxydants (), Antioxydants (pharmacologie), Antiviraux (), Antiviraux (pharmacologie), Dérivés du biphényle (), Extraits de plantes (), Extraits de plantes (pharmacologie), Facteur de nécrose tumorale alpha (métabolisme), Fruit (), Hydroxybenzoates (), Hydroxybenzoates (pharmacologie), Interleukine-6 (métabolisme), Lignée cellulaire, Macrophages (), Macrophages (métabolisme), Picrates (), Protoxyde d'azote (métabolisme), Rosaceae (), Sialidase (métabolisme), Souris, Sous-type H1N1 du virus de la grippe A ().
- MESH :
- métabolisme : Facteur de nécrose tumorale alpha, Interleukine-6, Macrophages, Protoxyde d'azote, Sialidase.
- pharmacologie : Anti-inflammatoires, Antioxydants, Antiviraux, Extraits de plantes, Hydroxybenzoates.
- Activation enzymatique, Animaux, Anti-inflammatoires, Antioxydants, Antiviraux, Dérivés du biphényle, Extraits de plantes, Fruit, Hydroxybenzoates, Lignée cellulaire, Macrophages, Picrates, Rosaceae, Souris, Sous-type H1N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Anti-Inflammatory Agents (chemistry), Anti-Inflammatory Agents (pharmacology), Antioxidants (chemistry), Antioxidants (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Biphenyl Compounds (chemistry), Cell Line, Enzyme Activation (drug effects), Fruit (chemistry), Hydroxybenzoates (chemistry), Hydroxybenzoates (pharmacology), Influenza A Virus, H1N1 Subtype (drug effects), Interleukin-6 (metabolism), Macrophages (drug effects), Macrophages (metabolism), Mice, Neuraminidase (metabolism), Nitrous Oxide (metabolism), Picrates (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Rosaceae (chemistry), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , chemistry : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents, Biphenyl Compounds, Hydroxybenzoates, Picrates, Plant Extracts.
- chemical , metabolism : Interleukin-6, Neuraminidase, Nitrous Oxide, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents, Hydroxybenzoates, Plant Extracts.
- chemistry : Fruit, Rosaceae.
- drug effects : Enzyme Activation, Influenza A Virus, H1N1 Subtype, Macrophages.
- metabolism : Macrophages.
- Animals, Cell Line, Mice.
Abstract
The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mg/mL and 1.27 mg/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC(50 )values of 3.82 mg/mL and 1.90 mg/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-a by 22.73%, 33.14% and 37.19% at 5 mg/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.
DOI: 10.3390/molecules15118507
PubMed: 21102377
Affiliations:
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Le document en format XML
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<term>Anti-Inflammatory Agents (pharmacology)</term>
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<term>Antioxidants (pharmacology)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Biphenyl Compounds (chemistry)</term>
<term>Cell Line</term>
<term>Enzyme Activation (drug effects)</term>
<term>Fruit (chemistry)</term>
<term>Hydroxybenzoates (chemistry)</term>
<term>Hydroxybenzoates (pharmacology)</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Interleukin-6 (metabolism)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (metabolism)</term>
<term>Mice</term>
<term>Neuraminidase (metabolism)</term>
<term>Nitrous Oxide (metabolism)</term>
<term>Picrates (chemistry)</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Rosaceae (chemistry)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
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<term>Anti-inflammatoires (pharmacologie)</term>
<term>Antioxydants ()</term>
<term>Antioxydants (pharmacologie)</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
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<term>Extraits de plantes ()</term>
<term>Extraits de plantes (pharmacologie)</term>
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<term>Picrates ()</term>
<term>Protoxyde d'azote (métabolisme)</term>
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<term>Antiviral Agents</term>
<term>Biphenyl Compounds</term>
<term>Hydroxybenzoates</term>
<term>Picrates</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fruit</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Enzyme Activation</term>
<term>Influenza A Virus, H1N1 Subtype</term>
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<term>Protoxyde d'azote</term>
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<term>Picrates</term>
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<front><div type="abstract" xml:lang="en">The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mg/mL and 1.27 mg/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC(50 )values of 3.82 mg/mL and 1.90 mg/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-a by 22.73%, 33.14% and 37.19% at 5 mg/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.</div>
</front>
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<name sortKey="Du, Guan Hua" sort="Du, Guan Hua" uniqKey="Du G" first="Guan-Hua" last="Du">Guan-Hua Du</name>
<name sortKey="Liu, Ai Lin" sort="Liu, Ai Lin" uniqKey="Liu A" first="Ai-Lin" last="Liu">Ai-Lin Liu</name>
<name sortKey="Wang, Hai Di" sort="Wang, Hai Di" uniqKey="Wang H" first="Hai-Di" last="Wang">Hai-Di Wang</name>
<name sortKey="Wang, Ya Ling" sort="Wang, Ya Ling" uniqKey="Wang Y" first="Ya-Ling" last="Wang">Ya-Ling Wang</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name>
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