Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.
Identifieur interne : 000664 ( PubMed/Corpus ); précédent : 000663; suivant : 000665Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.
Auteurs : Li Zhang ; Yong-Xian Cheng ; Ai-Lin Liu ; Hai-Di Wang ; Ya-Ling Wang ; Guan-Hua DuSource :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2010.
English descriptors
- KwdEn :
- Animals, Anti-Inflammatory Agents (chemistry), Anti-Inflammatory Agents (pharmacology), Antioxidants (chemistry), Antioxidants (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Biphenyl Compounds (chemistry), Cell Line, Enzyme Activation (drug effects), Fruit (chemistry), Hydroxybenzoates (chemistry), Hydroxybenzoates (pharmacology), Influenza A Virus, H1N1 Subtype (drug effects), Interleukin-6 (metabolism), Macrophages (drug effects), Macrophages (metabolism), Mice, Neuraminidase (metabolism), Nitrous Oxide (metabolism), Picrates (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Rosaceae (chemistry), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , chemistry : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents, Biphenyl Compounds, Hydroxybenzoates, Picrates, Plant Extracts.
- chemical , metabolism : Interleukin-6, Neuraminidase, Nitrous Oxide, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents, Hydroxybenzoates, Plant Extracts.
- chemistry : Fruit, Rosaceae.
- drug effects : Enzyme Activation, Influenza A Virus, H1N1 Subtype, Macrophages.
- metabolism : Macrophages.
- Animals, Cell Line, Mice.
Abstract
The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mg/mL and 1.27 mg/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC(50 )values of 3.82 mg/mL and 1.90 mg/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-a by 22.73%, 33.14% and 37.19% at 5 mg/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.
DOI: 10.3390/molecules15118507
PubMed: 21102377
Links to Exploration step
pubmed:21102377Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.</title><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Yong Xian" sort="Cheng, Yong Xian" uniqKey="Cheng Y" first="Yong-Xian" last="Cheng">Yong-Xian Cheng</name></author><author><name sortKey="Liu, Ai Lin" sort="Liu, Ai Lin" uniqKey="Liu A" first="Ai-Lin" last="Liu">Ai-Lin Liu</name></author><author><name sortKey="Wang, Hai Di" sort="Wang, Hai Di" uniqKey="Wang H" first="Hai-Di" last="Wang">Hai-Di Wang</name></author><author><name sortKey="Wang, Ya Ling" sort="Wang, Ya Ling" uniqKey="Wang Y" first="Ya-Ling" last="Wang">Ya-Ling Wang</name></author><author><name sortKey="Du, Guan Hua" sort="Du, Guan Hua" uniqKey="Du G" first="Guan-Hua" last="Du">Guan-Hua Du</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:21102377</idno><idno type="pmid">21102377</idno><idno type="doi">10.3390/molecules15118507</idno><idno type="wicri:Area/PubMed/Corpus">000664</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000664</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.</title><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Yong Xian" sort="Cheng, Yong Xian" uniqKey="Cheng Y" first="Yong-Xian" last="Cheng">Yong-Xian Cheng</name></author><author><name sortKey="Liu, Ai Lin" sort="Liu, Ai Lin" uniqKey="Liu A" first="Ai-Lin" last="Liu">Ai-Lin Liu</name></author><author><name sortKey="Wang, Hai Di" sort="Wang, Hai Di" uniqKey="Wang H" first="Hai-Di" last="Wang">Hai-Di Wang</name></author><author><name sortKey="Wang, Ya Ling" sort="Wang, Ya Ling" uniqKey="Wang Y" first="Ya-Ling" last="Wang">Ya-Ling Wang</name></author><author><name sortKey="Du, Guan Hua" sort="Du, Guan Hua" uniqKey="Du G" first="Guan-Hua" last="Du">Guan-Hua Du</name></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Inflammatory Agents (chemistry)</term><term>Anti-Inflammatory Agents (pharmacology)</term><term>Antioxidants (chemistry)</term><term>Antioxidants (pharmacology)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Biphenyl Compounds (chemistry)</term><term>Cell Line</term><term>Enzyme Activation (drug effects)</term><term>Fruit (chemistry)</term><term>Hydroxybenzoates (chemistry)</term><term>Hydroxybenzoates (pharmacology)</term><term>Influenza A Virus, H1N1 Subtype (drug effects)</term><term>Interleukin-6 (metabolism)</term><term>Macrophages (drug effects)</term><term>Macrophages (metabolism)</term><term>Mice</term><term>Neuraminidase (metabolism)</term><term>Nitrous Oxide (metabolism)</term><term>Picrates (chemistry)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Rosaceae (chemistry)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Antioxidants</term><term>Antiviral Agents</term><term>Biphenyl Compounds</term><term>Hydroxybenzoates</term><term>Picrates</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-6</term><term>Neuraminidase</term><term>Nitrous Oxide</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Antioxidants</term><term>Antiviral Agents</term><term>Hydroxybenzoates</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fruit</term><term>Rosaceae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Enzyme Activation</term><term>Influenza A Virus, H1N1 Subtype</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mg/mL and 1.27 mg/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC(50 )values of 3.82 mg/mL and 1.90 mg/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-a by 22.73%, 33.14% and 37.19% at 5 mg/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21102377</PMID><DateCompleted><Year>2011</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>07</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>11</Issue><PubDate><Year>2010</Year><Month>Nov</Month><Day>22</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.</ArticleTitle><Pagination><MedlinePgn>8507-17</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules15118507</ELocationID><Abstract><AbstractText>The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mg/mL and 1.27 mg/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC(50 )values of 3.82 mg/mL and 1.90 mg/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-a by 22.73%, 33.14% and 37.19% at 5 mg/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Yong-Xian</ForeName><Initials>YX</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ai-Lin</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hai-Di</ForeName><Initials>HD</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ya-Ling</ForeName><Initials>YL</Initials></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Guan-Hua</ForeName><Initials>GH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>11</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Molecules</MedlineTA><NlmUniqueID>100964009</NlmUniqueID><ISSNLinking>1420-3049</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001713">Biphenyl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D062385">Hydroxybenzoates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010851">Picrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>36R5QJ8L4B</RegistryNumber><NameOfSubstance UI="C009091">protocatechuic acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>DFD3H4VGDH</RegistryNumber><NameOfSubstance UI="C004931">1,1-diphenyl-2-picrylhydrazyl</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>K50XQU1029</RegistryNumber><NameOfSubstance UI="D009609">Nitrous Oxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001713" MajorTopicYN="N">Biphenyl Compounds</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062385" MajorTopicYN="N">Hydroxybenzoates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009609" MajorTopicYN="N">Nitrous Oxide</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010851" MajorTopicYN="N">Picrates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027824" MajorTopicYN="N">Rosaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>11</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>11</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>11</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21102377</ArticleId><ArticleId IdType="pii">molecules15118507</ArticleId><ArticleId IdType="doi">10.3390/molecules15118507</ArticleId><ArticleId IdType="pmc">PMC6259204</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2001 Jan;280(1):L69-78</Citation><ArticleIdList><ArticleId IdType="pubmed">11133496</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Pharm Bull (Tokyo). 2003 Jun;51(6):654-62</Citation><ArticleIdList><ArticleId IdType="pubmed">12808242</ArticleId></ArticleIdList></Reference><Reference><Citation>J Asian Nat Prod Res. 2008 Mar-Apr;10(3-4):217-22</Citation><ArticleIdList><ArticleId IdType="pubmed">18335336</ArticleId></ArticleIdList></Reference><Reference><Citation>J Ethnopharmacol. 2007 Sep 5;113(2):233-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17624704</ArticleId></ArticleIdList></Reference><Reference><Citation>Planta Med. 2008 Jun;74(8):847-51</Citation><ArticleIdList><ArticleId IdType="pubmed">18553272</ArticleId></ArticleIdList></Reference><Reference><Citation>Zhongguo Zhong Yao Za Zhi. 2006 Nov;31(22):1875-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17285988</ArticleId></ArticleIdList></Reference><Reference><Citation>Planta Med. 2003 Nov;69(11):1057-9</Citation><ArticleIdList><ArticleId IdType="pubmed">14735448</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2007 Mar 22;446(7134):358-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17377552</ArticleId></ArticleIdList></Reference><Reference><Citation>Eksp Klin Farmakol. 2007 Sep-Oct;70(5):33-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18074805</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1984 Sep;137(2):314-23</Citation><ArticleIdList><ArticleId IdType="pubmed">6485252</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Immunopharmacol. 2003 Apr;3(4):593-608</Citation><ArticleIdList><ArticleId IdType="pubmed">12689663</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Pharmacol Sin. 2003 Nov;24(11):1161-6</Citation><ArticleIdList><ArticleId IdType="pubmed">14627503</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nat Prod. 2003 Aug;66(8):1051-4</Citation><ArticleIdList><ArticleId IdType="pubmed">12932122</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Food. 2009 Oct;12(5):1016-22</Citation><ArticleIdList><ArticleId IdType="pubmed">19857064</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2002 Dec 7;360(9348):1831-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12480361</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8091-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18523003</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 2010 Feb 1;79(3):413-20</Citation><ArticleIdList><ArticleId IdType="pubmed">19732754</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000664 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000664 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:21102377
|texte= Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:21102377" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |