Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection.
Identifieur interne : 001295 ( Main/Exploration ); précédent : 001294; suivant : 001296Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection.
Auteurs : Benjamin Petsch [Allemagne] ; Margit Schnee ; Annette B. Vogel ; Elke Lange ; Bernd Hoffmann ; Daniel Voss ; Thomas Schlake ; Andreas Thess ; Karl-Josef Kallen ; Lothar Stitz ; Thomas KrampsSource :
- Nature biotechnology [ 1546-1696 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (immunologie), ARN viral (génétique), ARN viral (immunologie), Animaux, Animaux nouveau-nés, Biotechnologie, Données de séquences moléculaires, Femelle, Furets, Humains, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Lymphocytes B (immunologie), Lymphocytes T (immunologie), Protection croisée, Rats, Rats de lignée LEW, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Souris de lignée DBA, Sus scrofa, Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vieillissement (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie).
- MESH :
- génétique : ARN messager, ARN viral, Vaccins antigrippaux, Vaccins synthétiques, Virus de la grippe A.
- immunologie : ARN messager, ARN viral, Infections à Orthomyxoviridae, Lymphocytes B, Lymphocytes T, Vaccins antigrippaux, Vaccins synthétiques, Vieillissement, Virus de la grippe A.
- Animaux, Animaux nouveau-nés, Biotechnologie, Données de séquences moléculaires, Femelle, Furets, Humains, Infections à Orthomyxoviridae, Protection croisée, Rats, Rats de lignée LEW, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Souris de lignée DBA, Sus scrofa.
English descriptors
- KwdEn :
- Aging (immunology), Animals, Animals, Newborn, B-Lymphocytes (immunology), Biotechnology, Cross Protection, Female, Ferrets, Humans, Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), RNA, Messenger (genetics), RNA, Messenger (immunology), RNA, Viral (genetics), RNA, Viral (immunology), Rats, Rats, Inbred Lew, Sus scrofa, T-Lymphocytes (immunology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology).
- MESH :
- chemical , genetics : Influenza Vaccines, RNA, Messenger, RNA, Viral, Vaccines, Synthetic.
- genetics : Influenza A virus.
- immunology : Aging, B-Lymphocytes, Influenza A virus, Influenza Vaccines, Orthomyxoviridae Infections, RNA, Messenger, RNA, Viral, T-Lymphocytes, Vaccines, Synthetic.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Animals, Newborn, Biotechnology, Cross Protection, Female, Ferrets, Humans, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Rats, Rats, Inbred Lew, Sus scrofa.
Abstract
Despite substantial improvements, influenza vaccine production-and availability-remain suboptimal. Influenza vaccines based on mRNA may offer a solution as sequence-matched, clinical-grade material could be produced reliably and rapidly in a scalable process, allowing quick response to the emergence of pandemic strains. Here we show that mRNA vaccines induce balanced, long-lived and protective immunity to influenza A virus infections in even very young and very old mice and that the vaccine remains protective upon thermal stress. This vaccine format elicits B and T cell-dependent protection and targets multiple antigens, including the highly conserved viral nucleoprotein, indicating its usefulness as a cross-protective vaccine. In ferrets and pigs, mRNA vaccines induce immunological correlates of protection and protective effects similar to those of a licensed influenza vaccine in pigs. Thus, mRNA vaccines could address substantial medical need in the area of influenza prophylaxis and the broader realm of anti-infective vaccinology.
DOI: 10.1038/nbt.2436
PubMed: 23159882
Affiliations:
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Vogel</name></author><author><name sortKey="Lange, Elke" sort="Lange, Elke" uniqKey="Lange E" first="Elke" last="Lange">Elke Lange</name></author><author><name sortKey="Hoffmann, Bernd" sort="Hoffmann, Bernd" uniqKey="Hoffmann B" first="Bernd" last="Hoffmann">Bernd Hoffmann</name></author><author><name sortKey="Voss, Daniel" sort="Voss, Daniel" uniqKey="Voss D" first="Daniel" last="Voss">Daniel Voss</name></author><author><name sortKey="Schlake, Thomas" sort="Schlake, Thomas" uniqKey="Schlake T" first="Thomas" last="Schlake">Thomas Schlake</name></author><author><name sortKey="Thess, Andreas" sort="Thess, Andreas" uniqKey="Thess A" first="Andreas" last="Thess">Andreas Thess</name></author><author><name sortKey="Kallen, Karl Josef" sort="Kallen, Karl Josef" uniqKey="Kallen K" first="Karl-Josef" last="Kallen">Karl-Josef Kallen</name></author><author><name sortKey="Stitz, Lothar" sort="Stitz, Lothar" uniqKey="Stitz L" first="Lothar" last="Stitz">Lothar Stitz</name></author><author><name sortKey="Kramps, Thomas" sort="Kramps, Thomas" uniqKey="Kramps T" first="Thomas" last="Kramps">Thomas Kramps</name></author></analytic><series><title level="j">Nature biotechnology</title><idno type="eISSN">1546-1696</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (immunology)</term><term>Animals</term><term>Animals, Newborn</term><term>B-Lymphocytes (immunology)</term><term>Biotechnology</term><term>Cross Protection</term><term>Female</term><term>Ferrets</term><term>Humans</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred DBA</term><term>Molecular Sequence Data</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (immunology)</term><term>RNA, Viral (genetics)</term><term>RNA, Viral (immunology)</term><term>Rats</term><term>Rats, Inbred Lew</term><term>Sus scrofa</term><term>T-Lymphocytes (immunology)</term><term>Vaccines, Synthetic (genetics)</term><term>Vaccines, Synthetic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (immunologie)</term><term>ARN viral (génétique)</term><term>ARN viral (immunologie)</term><term>Animaux</term><term>Animaux nouveau-nés</term><term>Biotechnologie</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Furets</term><term>Humains</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T (immunologie)</term><term>Protection croisée</term><term>Rats</term><term>Rats de lignée LEW</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Souris de lignée DBA</term><term>Sus scrofa</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins synthétiques (génétique)</term><term>Vaccins synthétiques (immunologie)</term><term>Vieillissement (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Influenza Vaccines</term><term>RNA, Messenger</term><term>RNA, Viral</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>ARN viral</term><term>Vaccins 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Newborn</term><term>Biotechnology</term><term>Cross Protection</term><term>Female</term><term>Ferrets</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred DBA</term><term>Molecular Sequence Data</term><term>Rats</term><term>Rats, Inbred Lew</term><term>Sus scrofa</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Biotechnologie</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Furets</term><term>Humains</term><term>Infections à Orthomyxoviridae</term><term>Protection croisée</term><term>Rats</term><term>Rats de lignée LEW</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Souris de lignée DBA</term><term>Sus scrofa</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite substantial improvements, influenza vaccine production-and availability-remain suboptimal. Influenza vaccines based on mRNA may offer a solution as sequence-matched, clinical-grade material could be produced reliably and rapidly in a scalable process, allowing quick response to the emergence of pandemic strains. Here we show that mRNA vaccines induce balanced, long-lived and protective immunity to influenza A virus infections in even very young and very old mice and that the vaccine remains protective upon thermal stress. This vaccine format elicits B and T cell-dependent protection and targets multiple antigens, including the highly conserved viral nucleoprotein, indicating its usefulness as a cross-protective vaccine. In ferrets and pigs, mRNA vaccines induce immunological correlates of protection and protective effects similar to those of a licensed influenza vaccine in pigs. Thus, mRNA vaccines could address substantial medical need in the area of influenza prophylaxis and the broader realm of anti-infective vaccinology.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><noCountry><name sortKey="Hoffmann, Bernd" sort="Hoffmann, Bernd" uniqKey="Hoffmann B" first="Bernd" last="Hoffmann">Bernd Hoffmann</name><name sortKey="Kallen, Karl Josef" sort="Kallen, Karl Josef" uniqKey="Kallen K" first="Karl-Josef" last="Kallen">Karl-Josef Kallen</name><name sortKey="Kramps, Thomas" sort="Kramps, Thomas" uniqKey="Kramps T" first="Thomas" last="Kramps">Thomas Kramps</name><name sortKey="Lange, Elke" sort="Lange, Elke" uniqKey="Lange E" first="Elke" last="Lange">Elke Lange</name><name sortKey="Schlake, Thomas" sort="Schlake, Thomas" uniqKey="Schlake T" first="Thomas" last="Schlake">Thomas Schlake</name><name sortKey="Schnee, Margit" sort="Schnee, Margit" uniqKey="Schnee M" first="Margit" last="Schnee">Margit Schnee</name><name sortKey="Stitz, Lothar" sort="Stitz, Lothar" uniqKey="Stitz L" first="Lothar" last="Stitz">Lothar Stitz</name><name sortKey="Thess, Andreas" sort="Thess, Andreas" uniqKey="Thess A" first="Andreas" last="Thess">Andreas Thess</name><name sortKey="Vogel, Annette B" sort="Vogel, Annette B" uniqKey="Vogel A" first="Annette B" last="Vogel">Annette B. Vogel</name><name sortKey="Voss, Daniel" sort="Voss, Daniel" uniqKey="Voss D" first="Daniel" last="Voss">Daniel Voss</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Petsch, Benjamin" sort="Petsch, Benjamin" uniqKey="Petsch B" first="Benjamin" last="Petsch">Benjamin Petsch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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