Dose tapering for ciclosporin in cats with nonflea‐induced hypersensitivity dermatitis
Identifieur interne : 001087 ( Main/Exploration ); précédent : 001086; suivant : 001088Dose tapering for ciclosporin in cats with nonflea‐induced hypersensitivity dermatitis
Auteurs : Jean Steffan ; Elizabeth Roberts ; Andrea Cannon ; Pascal Prélaud ; Peter Forsythe ; Jacques Fontaine ; Stephen King ; Wolfgang SeewaldSource :
- Veterinary Dermatology [ 0959-4493 ] ; 2013.
Abstract
Little information is available on the ciclosporin dose‐tapering regimen and clinical response in the treatment of feline hypersensitivity dermatitis.
To test a dose‐tapering regimen and assess efficacy and clinical safety for up to 18 weeks.
Eighty‐eight client‐owned cats with feline hypersensitivity dermatitis.
Cats that received either a placebo or ciclosporin at 2.5 mg/kg or 7 mg/kg daily for 6 weeks were given 7 mg/kg ciclosporin daily for 4 weeks. Depending on the clinical response, the dose was tapered from daily to every other day over the next 4 weeks and further to twice a week for an additional 4 weeks.
After all cats received 7 mg/kg for 4 weeks, the dose could be tapered to every other day for the next 4 weeks in 70% of cats remaining in the study. During the next 4 weeks, 57, 15 and 22% of cats remaining in the study could be treated at twice a week, every other day or daily, respectively. After the first 4 weeks, the mean lesion score and owner‐assessed pruritus improved over baseline by 69 and 61%, respectively, and remained stable during the following 8 weeks. Approximately 65% of the cats in the study were reported to have an adverse event (
Results suggest that the induction dose of 7 mg/kg ciclosporin can be tapered as soon as 4 weeks without deterioration of the clinical response. Establishment of the lowest effective dosing regimen of ciclosporin reduced the frequency of
Url:
DOI: 10.1111/vde.12018
PubMed: 23530522
PubMed Central: 7169265
Affiliations:
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Le document en format XML
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<series><title level="j">Veterinary Dermatology</title>
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<front><div type="abstract" xml:lang="en"><sec id="vde12018-sec-0001"><title>Background</title>
<p>Little information is available on the ciclosporin dose‐tapering regimen and clinical response in the treatment of feline hypersensitivity dermatitis.</p>
</sec>
<sec id="vde12018-sec-0002"><title>Hypothesis/Objectives</title>
<p>To test a dose‐tapering regimen and assess efficacy and clinical safety for up to 18 weeks.</p>
</sec>
<sec id="vde12018-sec-0003"><title>Animals</title>
<p>Eighty‐eight client‐owned cats with feline hypersensitivity dermatitis.</p>
</sec>
<sec id="vde12018-sec-0004"><title>Methods</title>
<p>Cats that received either a placebo or ciclosporin at 2.5 mg/kg or 7 mg/kg daily for 6 weeks were given 7 mg/kg ciclosporin daily for 4 weeks. Depending on the clinical response, the dose was tapered from daily to every other day over the next 4 weeks and further to twice a week for an additional 4 weeks.</p>
</sec>
<sec id="vde12018-sec-0005"><title>Results</title>
<p>After all cats received 7 mg/kg for 4 weeks, the dose could be tapered to every other day for the next 4 weeks in 70% of cats remaining in the study. During the next 4 weeks, 57, 15 and 22% of cats remaining in the study could be treated at twice a week, every other day or daily, respectively. After the first 4 weeks, the mean lesion score and owner‐assessed pruritus improved over baseline by 69 and 61%, respectively, and remained stable during the following 8 weeks. Approximately 65% of the cats in the study were reported to have an adverse event (<styled-content style="fixed-case" toggle="no">AE</styled-content>
), very often mild and resolving spontaneously. The most frequent <styled-content style="fixed-case" toggle="no">AE</styled-content>
s were gastrointestinal and included primarily vomiting and diarrhoea. Eighty per cent of <styled-content style="fixed-case" toggle="no">AE</styled-content>
s occurred when cats were on daily treatment.</p>
</sec>
<sec id="vde12018-sec-0006"><title>Conclusions and clinical importance</title>
<p>Results suggest that the induction dose of 7 mg/kg ciclosporin can be tapered as soon as 4 weeks without deterioration of the clinical response. Establishment of the lowest effective dosing regimen of ciclosporin reduced the frequency of <styled-content style="fixed-case" toggle="no">AE</styled-content>
s.</p>
</sec>
</div>
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<name sortKey="Forsythe, Peter" sort="Forsythe, Peter" uniqKey="Forsythe P" first="Peter" last="Forsythe">Peter Forsythe</name>
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<name sortKey="Roberts, Elizabeth" sort="Roberts, Elizabeth" uniqKey="Roberts E" first="Elizabeth" last="Roberts">Elizabeth Roberts</name>
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