Dose tapering for ciclosporin in cats with nonflea‐induced hypersensitivity dermatitis
Identifieur interne : 001087 ( Main/Curation ); précédent : 001086; suivant : 001088Dose tapering for ciclosporin in cats with nonflea‐induced hypersensitivity dermatitis
Auteurs : Jean Steffan ; Elizabeth Roberts ; Andrea Cannon ; Pascal Prélaud ; Peter Forsythe ; Jacques Fontaine ; Stephen King ; Wolfgang SeewaldSource :
- Veterinary Dermatology [ 0959-4493 ] ; 2013.
Abstract
Little information is available on the ciclosporin dose‐tapering regimen and clinical response in the treatment of feline hypersensitivity dermatitis.
To test a dose‐tapering regimen and assess efficacy and clinical safety for up to 18 weeks.
Eighty‐eight client‐owned cats with feline hypersensitivity dermatitis.
Cats that received either a placebo or ciclosporin at 2.5 mg/kg or 7 mg/kg daily for 6 weeks were given 7 mg/kg ciclosporin daily for 4 weeks. Depending on the clinical response, the dose was tapered from daily to every other day over the next 4 weeks and further to twice a week for an additional 4 weeks.
After all cats received 7 mg/kg for 4 weeks, the dose could be tapered to every other day for the next 4 weeks in 70% of cats remaining in the study. During the next 4 weeks, 57, 15 and 22% of cats remaining in the study could be treated at twice a week, every other day or daily, respectively. After the first 4 weeks, the mean lesion score and owner‐assessed pruritus improved over baseline by 69 and 61%, respectively, and remained stable during the following 8 weeks. Approximately 65% of the cats in the study were reported to have an adverse event (
Results suggest that the induction dose of 7 mg/kg ciclosporin can be tapered as soon as 4 weeks without deterioration of the clinical response. Establishment of the lowest effective dosing regimen of ciclosporin reduced the frequency of
Url:
DOI: 10.1111/vde.12018
PubMed: 23530522
PubMed Central: 7169265
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id="vde12018-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Forsythe, Peter" sort="Forsythe, Peter" uniqKey="Forsythe P" first="Peter" last="Forsythe">Peter Forsythe</name><affiliation><nlm:aff id="vde12018-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Fontaine, Jacques" sort="Fontaine, Jacques" uniqKey="Fontaine J" first="Jacques" last="Fontaine">Jacques Fontaine</name><affiliation><nlm:aff id="vde12018-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="King, Stephen" sort="King, Stephen" uniqKey="King S" first="Stephen" last="King">Stephen King</name><affiliation><nlm:aff id="vde12018-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Seewald, Wolfgang" sort="Seewald, Wolfgang" uniqKey="Seewald W" first="Wolfgang" last="Seewald">Wolfgang Seewald</name><affiliation><nlm:aff id="vde12018-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno 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type="wicri:Area/Main/Curation">001087</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dose tapering for ciclosporin in cats with nonflea‐induced hypersensitivity dermatitis</title><author><name sortKey="Steffan, Jean" sort="Steffan, Jean" uniqKey="Steffan J" first="Jean" last="Steffan">Jean Steffan</name><affiliation><nlm:aff id="vde12018-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Roberts, Elizabeth" sort="Roberts, Elizabeth" uniqKey="Roberts E" first="Elizabeth" last="Roberts">Elizabeth Roberts</name><affiliation><nlm:aff id="vde12018-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Cannon, Andrea" sort="Cannon, Andrea" uniqKey="Cannon A" first="Andrea" last="Cannon">Andrea Cannon</name><affiliation><nlm:aff id="vde12018-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Prelaud, Pascal" sort="Prelaud, Pascal" uniqKey="Prelaud P" first="Pascal" last="Prélaud">Pascal Prélaud</name><affiliation><nlm:aff id="vde12018-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Forsythe, Peter" sort="Forsythe, Peter" uniqKey="Forsythe P" first="Peter" last="Forsythe">Peter Forsythe</name><affiliation><nlm:aff id="vde12018-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Fontaine, Jacques" sort="Fontaine, Jacques" uniqKey="Fontaine J" first="Jacques" last="Fontaine">Jacques Fontaine</name><affiliation><nlm:aff id="vde12018-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="King, Stephen" sort="King, Stephen" uniqKey="King S" first="Stephen" last="King">Stephen King</name><affiliation><nlm:aff id="vde12018-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Seewald, Wolfgang" sort="Seewald, Wolfgang" uniqKey="Seewald W" first="Wolfgang" last="Seewald">Wolfgang Seewald</name><affiliation><nlm:aff id="vde12018-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Veterinary Dermatology</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="vde12018-sec-0001"><title>Background</title><p>Little information is available on the ciclosporin dose‐tapering regimen and clinical response in the treatment of feline hypersensitivity dermatitis.</p></sec><sec id="vde12018-sec-0002"><title>Hypothesis/Objectives</title><p>To test a dose‐tapering regimen and assess efficacy and clinical safety for up to 18 weeks.</p></sec><sec id="vde12018-sec-0003"><title>Animals</title><p>Eighty‐eight client‐owned cats with feline hypersensitivity dermatitis.</p></sec><sec id="vde12018-sec-0004"><title>Methods</title><p>Cats that received either a placebo or ciclosporin at 2.5 mg/kg or 7 mg/kg daily for 6 weeks were given 7 mg/kg ciclosporin daily for 4 weeks. Depending on the clinical response, the dose was tapered from daily to every other day over the next 4 weeks and further to twice a week for an additional 4 weeks.</p></sec><sec id="vde12018-sec-0005"><title>Results</title><p>After all cats received 7 mg/kg for 4 weeks, the dose could be tapered to every other day for the next 4 weeks in 70% of cats remaining in the study. During the next 4 weeks, 57, 15 and 22% of cats remaining in the study could be treated at twice a week, every other day or daily, respectively. After the first 4 weeks, the mean lesion score and owner‐assessed pruritus improved over baseline by 69 and 61%, respectively, and remained stable during the following 8 weeks. Approximately 65% of the cats in the study were reported to have an adverse event (<styled-content style="fixed-case" toggle="no">AE</styled-content>), very often mild and resolving spontaneously. The most frequent <styled-content style="fixed-case" toggle="no">AE</styled-content>s were gastrointestinal and included primarily vomiting and diarrhoea. Eighty per cent of <styled-content style="fixed-case" toggle="no">AE</styled-content>s occurred when cats were on daily treatment.</p></sec><sec id="vde12018-sec-0006"><title>Conclusions and clinical importance</title><p>Results suggest that the induction dose of 7 mg/kg ciclosporin can be tapered as soon as 4 weeks without deterioration of the clinical response. Establishment of the lowest effective dosing regimen of ciclosporin reduced the frequency of <styled-content style="fixed-case" toggle="no">AE</styled-content>s.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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