The challenges in developing effective canine infectious respiratory disease vaccines
Identifieur interne : 000C99 ( Main/Exploration ); précédent : 000C98; suivant : 000D00The challenges in developing effective canine infectious respiratory disease vaccines
Auteurs : Judy A. Mitchell ; Joe BrownlieSource :
- The Journal of Pharmacy and Pharmacology [ 0022-3573 ] ; 2015.
Abstract
Canine infectious respiratory disease (
Innate immune responses provide a vital first line of defence against the infectious agents involved in the development of
In the process of considering the development of novel
Url:
DOI: 10.1111/jphp.12380
PubMed: 25736813
PubMed Central: 7166679
Affiliations:
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Le document en format XML
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Mitchell</name><affiliation><nlm:aff id="jphp12380-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Brownlie, Joe" sort="Brownlie, Joe" uniqKey="Brownlie J" first="Joe" last="Brownlie">Joe Brownlie</name><affiliation><nlm:aff id="jphp12380-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25736813</idno><idno type="pmc">7166679</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166679</idno><idno type="RBID">PMC:7166679</idno><idno type="doi">10.1111/jphp.12380</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000954</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000954</idno><idno type="wicri:Area/Pmc/Curation">000954</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000954</idno><idno type="wicri:Area/Pmc/Checkpoint">000792</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000792</idno><idno type="wicri:Area/Ncbi/Merge">000702</idno><idno type="wicri:Area/Ncbi/Curation">000702</idno><idno type="wicri:Area/Ncbi/Checkpoint">000702</idno><idno type="wicri:doubleKey">0022-3573:2015:Mitchell J:the:challenges:in</idno><idno type="wicri:Area/Main/Merge">000D00</idno><idno type="wicri:Area/Main/Curation">000C99</idno><idno type="wicri:Area/Main/Exploration">000C99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The challenges in developing effective canine infectious respiratory disease vaccines</title><author><name sortKey="Mitchell, Judy A" sort="Mitchell, Judy A" uniqKey="Mitchell J" first="Judy A." last="Mitchell">Judy A. Mitchell</name><affiliation><nlm:aff id="jphp12380-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Brownlie, Joe" sort="Brownlie, Joe" uniqKey="Brownlie J" first="Joe" last="Brownlie">Joe Brownlie</name><affiliation><nlm:aff id="jphp12380-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Pharmacy and Pharmacology</title><idno type="ISSN">0022-3573</idno><idno type="eISSN">2042-7158</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="jphp12380-sec-0001"><title>Objectives</title><p>Canine infectious respiratory disease (<styled-content style="fixed-case" toggle="no">CIRD</styled-content>) is a disease of multifactorial aetiology, where multiple pathogens act sequentially or synergistically to cause disease. It is common within large dog populations, such as those in re‐homing or training kennels. Vaccines are vital in its management of <styled-content style="fixed-case" toggle="no">CIRD</styled-content>, but they often fail to prevent disease. Recently, a number of novel pathogens have been identified in <styled-content style="fixed-case" toggle="no">CIRD</styled-content> outbreaks and represent new targets for vaccination.</p></sec><sec id="jphp12380-sec-0002"><title>Key findings</title><p>Innate immune responses provide a vital first line of defence against the infectious agents involved in the development of <styled-content style="fixed-case" toggle="no">CIRD</styled-content>. Once breeched, adaptive mucosal immunity is necessary to prevent infection and limit spread. Current vaccines target only a few of the agents involved in <styled-content style="fixed-case" toggle="no">CIRD</styled-content>. Evidence, from the limited amount of published data, indicates that although vaccinating against these agents reduces infection rates, duration of shedding and severity of disease, it does not induce sterilising immunity; and this has important consequences for the management of the disease, and the future of <styled-content style="fixed-case" toggle="no">CIRD</styled-content> vaccine development.</p></sec><sec id="jphp12380-sec-0003"><title>Summary</title><p>In the process of considering the development of novel <styled-content style="fixed-case" toggle="no">CIRD</styled-content> vaccines, this paper focuses on the immunological mechanisms that provide protection for the respiratory tract, the current recommendations for canine vaccination, and the challenges surrounding existing <styled-content style="fixed-case" toggle="no">CIRD</styled-content> vaccines, and their future development.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Appel, M" uniqKey="Appel M">M. 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