Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome
Identifieur interne : 000A77 ( Main/Exploration ); précédent : 000A76; suivant : 000A78Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome
Auteurs : Nuala J. Meyer [États-Unis] ; Carolyn S. Calfee [États-Unis]Source :
- The Lancet. Respiratory Medicine [ 2213-2600 ] ; 2017.
Abstract
In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression patterns in plasma and bronchoalveolar lavage fluid from patients with ARDS. Despite this effort, however, pharmacological options for ARDS remain scarce. Frequently cited reasons for this absence of specific drug therapies include the heterogeneity of patients with ARDS, the potential for a differential response to drugs, and the possibility that the wrong targets have been studied. Advances in applied biomolecular technology and bioinformatics have enabled breakthroughs for other complex traits, such as cardiovascular disease or asthma, particularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern indicates a patient's likelihood of responding to a treatment, has been pursued. In this Review, we consider the biological and analytical techniques that could facilitate a precision medicine approach for ARDS.
Url:
DOI: 10.1016/S2213-2600(17)30187-X
PubMed: 28664850
PubMed Central: 7103930
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome</title><author><name sortKey="Meyer, Nuala J" sort="Meyer, Nuala J" uniqKey="Meyer N" first="Nuala J" last="Meyer">Nuala J. Meyer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Calfee, Carolyn S" sort="Calfee, Carolyn S" uniqKey="Calfee C" first="Carolyn S" last="Calfee">Carolyn S. Calfee</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28664850</idno><idno type="pmc">7103930</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103930</idno><idno type="RBID">PMC:7103930</idno><idno type="doi">10.1016/S2213-2600(17)30187-X</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000961</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000961</idno><idno type="wicri:Area/Pmc/Curation">000961</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000961</idno><idno type="wicri:Area/Pmc/Checkpoint">000756</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000756</idno><idno type="wicri:Area/Ncbi/Merge">000867</idno><idno type="wicri:Area/Ncbi/Curation">000867</idno><idno type="wicri:Area/Ncbi/Checkpoint">000867</idno><idno type="wicri:doubleKey">2213-2600:2017:Meyer N:novel:translational:approaches</idno><idno type="wicri:Area/Main/Merge">000A78</idno><idno type="wicri:Area/Main/Curation">000A77</idno><idno type="wicri:Area/Main/Exploration">000A77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome</title><author><name sortKey="Meyer, Nuala J" sort="Meyer, Nuala J" uniqKey="Meyer N" first="Nuala J" last="Meyer">Nuala J. Meyer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Calfee, Carolyn S" sort="Calfee, Carolyn S" uniqKey="Calfee C" first="Carolyn S" last="Calfee">Carolyn S. Calfee</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory Medicine</title><idno type="ISSN">2213-2600</idno><idno type="eISSN">2213-2619</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression patterns in plasma and bronchoalveolar lavage fluid from patients with ARDS. Despite this effort, however, pharmacological options for ARDS remain scarce. Frequently cited reasons for this absence of specific drug therapies include the heterogeneity of patients with ARDS, the potential for a differential response to drugs, and the possibility that the wrong targets have been studied. Advances in applied biomolecular technology and bioinformatics have enabled breakthroughs for other complex traits, such as cardiovascular disease or asthma, particularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern indicates a patient's likelihood of responding to a treatment, has been pursued. 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Eisner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author><author><name sortKey="Mcauley, Df" uniqKey="Mcauley D">DF McAuley</name></author><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Meyer, Nuala J" sort="Meyer, Nuala J" uniqKey="Meyer N" first="Nuala J" last="Meyer">Nuala J. Meyer</name></region><name sortKey="Calfee, Carolyn S" sort="Calfee, Carolyn S" uniqKey="Calfee C" first="Carolyn S" last="Calfee">Carolyn S. Calfee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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