Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome
Identifieur interne : 000867 ( Ncbi/Merge ); précédent : 000866; suivant : 000868Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome
Auteurs : Nuala J. Meyer [États-Unis] ; Carolyn S. Calfee [États-Unis]Source :
- The Lancet. Respiratory Medicine [ 2213-2600 ] ; 2017.
Abstract
In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression patterns in plasma and bronchoalveolar lavage fluid from patients with ARDS. Despite this effort, however, pharmacological options for ARDS remain scarce. Frequently cited reasons for this absence of specific drug therapies include the heterogeneity of patients with ARDS, the potential for a differential response to drugs, and the possibility that the wrong targets have been studied. Advances in applied biomolecular technology and bioinformatics have enabled breakthroughs for other complex traits, such as cardiovascular disease or asthma, particularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern indicates a patient's likelihood of responding to a treatment, has been pursued. In this Review, we consider the biological and analytical techniques that could facilitate a precision medicine approach for ARDS.
Url:
DOI: 10.1016/S2213-2600(17)30187-X
PubMed: 28664850
PubMed Central: 7103930
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000961
- to stream Pmc, to step Curation: 000961
- to stream Pmc, to step Checkpoint: 000756
Links to Exploration step
PMC:7103930Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome</title><author><name sortKey="Meyer, Nuala J" sort="Meyer, Nuala J" uniqKey="Meyer N" first="Nuala J" last="Meyer">Nuala J. Meyer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Calfee, Carolyn S" sort="Calfee, Carolyn S" uniqKey="Calfee C" first="Carolyn S" last="Calfee">Carolyn S. Calfee</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28664850</idno><idno type="pmc">7103930</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103930</idno><idno type="RBID">PMC:7103930</idno><idno type="doi">10.1016/S2213-2600(17)30187-X</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000961</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000961</idno><idno type="wicri:Area/Pmc/Curation">000961</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000961</idno><idno type="wicri:Area/Pmc/Checkpoint">000756</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000756</idno><idno type="wicri:Area/Ncbi/Merge">000867</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome</title><author><name sortKey="Meyer, Nuala J" sort="Meyer, Nuala J" uniqKey="Meyer N" first="Nuala J" last="Meyer">Nuala J. Meyer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Calfee, Carolyn S" sort="Calfee, Carolyn S" uniqKey="Calfee C" first="Carolyn S" last="Calfee">Carolyn S. Calfee</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory Medicine</title><idno type="ISSN">2213-2600</idno><idno type="eISSN">2213-2619</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression patterns in plasma and bronchoalveolar lavage fluid from patients with ARDS. Despite this effort, however, pharmacological options for ARDS remain scarce. Frequently cited reasons for this absence of specific drug therapies include the heterogeneity of patients with ARDS, the potential for a differential response to drugs, and the possibility that the wrong targets have been studied. Advances in applied biomolecular technology and bioinformatics have enabled breakthroughs for other complex traits, such as cardiovascular disease or asthma, particularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern indicates a patient's likelihood of responding to a treatment, has been pursued. In this Review, we consider the biological and analytical techniques that could facilitate a precision medicine approach for ARDS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashbaugh, Dg" uniqKey="Ashbaugh D">DG Ashbaugh</name></author><author><name sortKey="Bigelow, Db" uniqKey="Bigelow D">DB Bigelow</name></author><author><name sortKey="Petty, Tl" uniqKey="Petty T">TL Petty</name></author><author><name sortKey="Levine, Be" uniqKey="Levine B">BE Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Network, Ards" uniqKey="Network A">ARDS Network</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dellinger, Rp" uniqKey="Dellinger R">RP Dellinger</name></author><author><name sortKey="Levy, Mm" uniqKey="Levy M">MM Levy</name></author><author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name></author><author><name sortKey="Evans, Le" uniqKey="Evans L">LE Evans</name></author><author><name sortKey="Alhazzani, W" uniqKey="Alhazzani W">W Alhazzani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ouellette, Dr" uniqKey="Ouellette D">DR Ouellette</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Girard, Td" uniqKey="Girard T">TD Girard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Girard, Td" uniqKey="Girard T">TD Girard</name></author><author><name sortKey="Alhazzani, W" uniqKey="Alhazzani W">W Alhazzani</name></author><author><name sortKey="Kress, Jp" uniqKey="Kress J">JP Kress</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellani, G" uniqKey="Bellani G">G Bellani</name></author><author><name sortKey="Laffey, Jg" uniqKey="Laffey J">JG Laffey</name></author><author><name sortKey="Pham, T" uniqKey="Pham T">T Pham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name></author><author><name sortKey="Rubenfeld, Gd" uniqKey="Rubenfeld G">GD Rubenfeld</name></author><author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papazian, L" uniqKey="Papazian L">L Papazian</name></author><author><name sortKey="Forel, Jm" uniqKey="Forel J">JM Forel</name></author><author><name sortKey="Gacouin, A" uniqKey="Gacouin A">A Gacouin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Truwit, Jd" uniqKey="Truwit J">JD Truwit</name></author><author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name></author><author><name sortKey="Steingrub, J" uniqKey="Steingrub J">J Steingrub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauley, Df" uniqKey="Mcauley D">DF McAuley</name></author><author><name sortKey="Laffey, Jg" uniqKey="Laffey J">JG Laffey</name></author><author><name sortKey="O Kane, Cm" uniqKey="O Kane C">CM O'Kane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Fg" uniqKey="Smith F">FG Smith</name></author><author><name sortKey="Perkins, Gd" uniqKey="Perkins G">GD Perkins</name></author><author><name sortKey="Gates, S" uniqKey="Gates S">S Gates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author><author><name sortKey="Brower, Rg" uniqKey="Brower R">RG Brower</name></author><author><name sortKey="Carson, S" uniqKey="Carson S">S Carson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeiher, Bg" uniqKey="Zeiher B">BG Zeiher</name></author><author><name sortKey="Artigas, A" uniqKey="Artigas A">A Artigas</name></author><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Delucchi, K" uniqKey="Delucchi K">K Delucchi</name></author><author><name sortKey="Parsons, Pe" uniqKey="Parsons P">PE Parsons</name></author><author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name></author><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenner, Js" uniqKey="Brenner J">JS Brenner</name></author><author><name sortKey="Greineder, C" uniqKey="Greineder C">C Greineder</name></author><author><name sortKey="Shuvaev, V" uniqKey="Shuvaev V">V Shuvaev</name></author><author><name sortKey="Muzykantov, V" uniqKey="Muzykantov V">V Muzykantov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Famous, Kr" uniqKey="Famous K">KR Famous</name></author><author><name sortKey="Delucchi, K" uniqKey="Delucchi K">K Delucchi</name></author><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beitler, Jr" uniqKey="Beitler J">JR Beitler</name></author><author><name sortKey="Goligher, Ec" uniqKey="Goligher E">EC Goligher</name></author><author><name sortKey="Schmidt, M" uniqKey="Schmidt M">M Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prescott, Hc" uniqKey="Prescott H">HC Prescott</name></author><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name></author><author><name sortKey="Angus, Dc" uniqKey="Angus D">DC Angus</name></author><author><name sortKey="Liu, Vx" uniqKey="Liu V">VX Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name></author><author><name sortKey="Suter, Pm" uniqKey="Suter P">PM Suter</name></author><author><name sortKey="Tortorella, C" uniqKey="Tortorella C">C Tortorella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parsons, Pe" uniqKey="Parsons P">PE Parsons</name></author><author><name sortKey="Eisner, Md" uniqKey="Eisner M">MD Eisner</name></author><author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meduri, Gu" uniqKey="Meduri G">GU Meduri</name></author><author><name sortKey="Headley, S" uniqKey="Headley S">S Headley</name></author><author><name sortKey="Kohler, G" uniqKey="Kohler G">G Kohler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meduri, Gu" uniqKey="Meduri G">GU Meduri</name></author><author><name sortKey="Kohler, G" uniqKey="Kohler G">G Kohler</name></author><author><name sortKey="Headley, S" uniqKey="Headley S">S Headley</name></author><author><name sortKey="Tolley, E" uniqKey="Tolley E">E Tolley</name></author><author><name sortKey="Stentz, F" uniqKey="Stentz F">F Stentz</name></author><author><name sortKey="Postlethwaite, A" uniqKey="Postlethwaite A">A Postlethwaite</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katzenstein, Al" uniqKey="Katzenstein A">AL Katzenstein</name></author><author><name sortKey="Bloor, Cm" uniqKey="Bloor C">CM Bloor</name></author><author><name sortKey="Leibow, Aa" uniqKey="Leibow A">AA Leibow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiener Kronish, Jp" uniqKey="Wiener Kronish J">JP Wiener-Kronish</name></author><author><name sortKey="Albertine, Kh" uniqKey="Albertine K">KH Albertine</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Nj" uniqKey="Meyer N">NJ Meyer</name></author><author><name sortKey="Christie, Jd" uniqKey="Christie J">JD Christie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Nj" uniqKey="Meyer N">NJ Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blondonnet, R" uniqKey="Blondonnet R">R Blondonnet</name></author><author><name sortKey="Constantin, Jm" uniqKey="Constantin J">JM Constantin</name></author><author><name sortKey="Sapin, V" uniqKey="Sapin V">V Sapin</name></author><author><name sortKey="Jabaudon, M" uniqKey="Jabaudon M">M Jabaudon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Sm" uniqKey="Brown S">SM Brown</name></author><author><name sortKey="Grissom, Ck" uniqKey="Grissom C">CK Grissom</name></author><author><name sortKey="Rondina, Mt" uniqKey="Rondina M">MT Rondina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shortt, K" uniqKey="Shortt K">K Shortt</name></author><author><name sortKey="Chaudhary, S" uniqKey="Chaudhary S">S Chaudhary</name></author><author><name sortKey="Grigoryev, D" uniqKey="Grigoryev D">D Grigoryev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sapru, A" uniqKey="Sapru A">A Sapru</name></author><author><name sortKey="Liu, Kd" uniqKey="Liu K">KD Liu</name></author><author><name sortKey="Wiemels, J" uniqKey="Wiemels J">J Wiemels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, Cc" uniqKey="Ghosh C">CC Ghosh</name></author><author><name sortKey="David, S" uniqKey="David S">S David</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Cr" uniqKey="Evans C">CR Evans</name></author><author><name sortKey="Karnovsky, A" uniqKey="Karnovsky A">A Karnovsky</name></author><author><name sortKey="Kovach, Ma" uniqKey="Kovach M">MA Kovach</name></author><author><name sortKey="Standiford, Tj" uniqKey="Standiford T">TJ Standiford</name></author><author><name sortKey="Burant, Cf" uniqKey="Burant C">CF Burant</name></author><author><name sortKey="Stringer, Ka" uniqKey="Stringer K">KA Stringer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stringer, Ka" uniqKey="Stringer K">KA Stringer</name></author><author><name sortKey="Serkova, Nj" uniqKey="Serkova N">NJ Serkova</name></author><author><name sortKey="Karnovsky, A" uniqKey="Karnovsky A">A Karnovsky</name></author><author><name sortKey="Guire, K" uniqKey="Guire K">K Guire</name></author><author><name sortKey="Paine, R" uniqKey="Paine R">R Paine</name></author><author><name sortKey="Standiford, Tj" uniqKey="Standiford T">TJ Standiford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Janz, Dr" uniqKey="Janz D">DR Janz</name></author><author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blondonnet, R" uniqKey="Blondonnet R">R Blondonnet</name></author><author><name sortKey="Constantin, Jm" uniqKey="Constantin J">JM Constantin</name></author><author><name sortKey="Sapin, V" uniqKey="Sapin V">V Sapin</name></author><author><name sortKey="Jabaudon, M" uniqKey="Jabaudon M">M Jabaudon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forel, Jm" uniqKey="Forel J">JM Forel</name></author><author><name sortKey="Guervilly, C" uniqKey="Guervilly C">C Guervilly</name></author><author><name sortKey="Hraiech, S" uniqKey="Hraiech S">S Hraiech</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Battaglia, M" uniqKey="Battaglia M">M Battaglia</name></author><author><name sortKey="Atkinson, Ma" uniqKey="Atkinson M">MA Atkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manolio, Ta" uniqKey="Manolio T">TA Manolio</name></author><author><name sortKey="Collins, Fs" uniqKey="Collins F">FS Collins</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christie, Jd" uniqKey="Christie J">JD Christie</name></author><author><name sortKey="Wurfel, Mm" uniqKey="Wurfel M">MM Wurfel</name></author><author><name sortKey="Feng, R" uniqKey="Feng R">R Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angus, Dc" uniqKey="Angus D">DC Angus</name></author><author><name sortKey="Linde Zwirble, Wt" uniqKey="Linde Zwirble W">WT Linde-Zwirble</name></author><author><name sortKey="Lidicker, J" uniqKey="Lidicker J">J Lidicker</name></author><author><name sortKey="Clermont, G" uniqKey="Clermont G">G Clermont</name></author><author><name sortKey="Carcillo, J" uniqKey="Carcillo J">J Carcillo</name></author><author><name sortKey="Pinsky, Mr" uniqKey="Pinsky M">MR Pinsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Copeland, Kt" uniqKey="Copeland K">KT Copeland</name></author><author><name sortKey="Checkoway, H" uniqKey="Checkoway H">H Checkoway</name></author><author><name sortKey="Mcmichael, Aj" uniqKey="Mcmichael A">AJ McMichael</name></author><author><name sortKey="Holbrook, Rh" uniqKey="Holbrook R">RH Holbrook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tejera, P" uniqKey="Tejera P">P Tejera</name></author><author><name sortKey="Meyer, Nj" uniqKey="Meyer N">NJ Meyer</name></author><author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, G" uniqKey="Gibson G">G Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tennessen, Ja" uniqKey="Tennessen J">JA Tennessen</name></author><author><name sortKey="Bigham, Aw" uniqKey="Bigham A">AW Bigham</name></author><author><name sortKey="O Connor, Td" uniqKey="O Connor T">TD O'Connor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Posey, Je" uniqKey="Posey J">JE Posey</name></author><author><name sortKey="Harel, T" uniqKey="Harel T">T Harel</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Djebali, S" uniqKey="Djebali S">S Djebali</name></author><author><name sortKey="Davis, Ca" uniqKey="Davis C">CA Davis</name></author><author><name sortKey="Merkel, A" uniqKey="Merkel A">A Merkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Gerstein, M" uniqKey="Gerstein M">M Gerstein</name></author><author><name sortKey="Snyder, M" uniqKey="Snyder M">M Snyder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, G" uniqKey="Gibson G">G Gibson</name></author><author><name sortKey="Powell, Je" uniqKey="Powell J">JE Powell</name></author><author><name sortKey="Marigorta, Um" uniqKey="Marigorta U">UM Marigorta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palakshappa, Ja" uniqKey="Palakshappa J">JA Palakshappa</name></author><author><name sortKey="Meyer, Nj" uniqKey="Meyer N">NJ Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovach, Ma" uniqKey="Kovach M">MA Kovach</name></author><author><name sortKey="Stringer, Ka" uniqKey="Stringer K">KA Stringer</name></author><author><name sortKey="Bunting, R" uniqKey="Bunting R">R Bunting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aggarwal, Nr" uniqKey="Aggarwal N">NR Aggarwal</name></author><author><name sortKey="King, Ls" uniqKey="King L">LS King</name></author><author><name sortKey="D Alessio, Fr" uniqKey="D Alessio F">FR D'Alessio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kangelaris, Kn" uniqKey="Kangelaris K">KN Kangelaris</name></author><author><name sortKey="Prakash, A" uniqKey="Prakash A">A Prakash</name></author><author><name sortKey="Liu, Kd" uniqKey="Liu K">KD Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howrylak, Ja" uniqKey="Howrylak J">JA Howrylak</name></author><author><name sortKey="Dolinay, T" uniqKey="Dolinay T">T Dolinay</name></author><author><name sortKey="Lucht, L" uniqKey="Lucht L">L Lucht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, Aj" uniqKey="Rogers A">AJ Rogers</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhargava, M" uniqKey="Bhargava M">M Bhargava</name></author><author><name sortKey="Becker, Tl" uniqKey="Becker T">TL Becker</name></author><author><name sortKey="Viken, Kj" uniqKey="Viken K">KJ Viken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Shan, Q" uniqKey="Shan Q">Q Shan</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhu, B" uniqKey="Zhu B">B Zhu</name></author><author><name sortKey="Xi, X" uniqKey="Xi X">X Xi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerszten, Re" uniqKey="Gerszten R">RE Gerszten</name></author><author><name sortKey="Accurso, F" uniqKey="Accurso F">F Accurso</name></author><author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bos, Ldj" uniqKey="Bos L">LDJ Bos</name></author><author><name sortKey="Weda, H" uniqKey="Weda H">H Weda</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gajic, O" uniqKey="Gajic O">O Gajic</name></author><author><name sortKey="Dabbagh, O" uniqKey="Dabbagh O">O Dabbagh</name></author><author><name sortKey="Park, Pk" uniqKey="Park P">PK Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trillo Alvarez, C" uniqKey="Trillo Alvarez C">C Trillo-Alvarez</name></author><author><name sortKey="Cartin Ceba, R" uniqKey="Cartin Ceba R">R Cartin-Ceba</name></author><author><name sortKey="Kor, Dj" uniqKey="Kor D">DJ Kor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dickson, Rp" uniqKey="Dickson R">RP Dickson</name></author><author><name sortKey="Singer, Bh" uniqKey="Singer B">BH Singer</name></author><author><name sortKey="Newstead, Mw" uniqKey="Newstead M">MW Newstead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name></author><author><name sortKey="Artigas, A" uniqKey="Artigas A">A Artigas</name></author><author><name sortKey="Brigham, Kl" uniqKey="Brigham K">KL Brigham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, Ep" uniqKey="Schmidt E">EP Schmidt</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mrozek, S" uniqKey="Mrozek S">S Mrozek</name></author><author><name sortKey="Jabaudon, M" uniqKey="Jabaudon M">M Jabaudon</name></author><author><name sortKey="Jaber, S" uniqKey="Jaber S">S Jaber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Eisner, Md" uniqKey="Eisner M">MD Eisner</name></author><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Constantin, Jm" uniqKey="Constantin J">JM Constantin</name></author><author><name sortKey="Grasso, S" uniqKey="Grasso S">S Grasso</name></author><author><name sortKey="Chanques, G" uniqKey="Chanques G">G Chanques</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haldar, P" uniqKey="Haldar P">P Haldar</name></author><author><name sortKey="Pavord, Id" uniqKey="Pavord I">ID Pavord</name></author><author><name sortKey="Shaw, De" uniqKey="Shaw D">DE Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Wc" uniqKey="Moore W">WC Moore</name></author><author><name sortKey="Meyers, Da" uniqKey="Meyers D">DA Meyers</name></author><author><name sortKey="Wenzel, Se" uniqKey="Wenzel S">SE Wenzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Hr" uniqKey="Wong H">HR Wong</name></author><author><name sortKey="Cvijanovich, N" uniqKey="Cvijanovich N">N Cvijanovich</name></author><author><name sortKey="Lin, R" uniqKey="Lin R">R Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Hr" uniqKey="Wong H">HR Wong</name></author><author><name sortKey="Cvijanovich, Nz" uniqKey="Cvijanovich N">NZ Cvijanovich</name></author><author><name sortKey="Anas, N" uniqKey="Anas N">N Anas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quackenbush, J" uniqKey="Quackenbush J">J Quackenbush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charrad, M" uniqKey="Charrad M">M Charrad</name></author><author><name sortKey="Ghazzali, N" uniqKey="Ghazzali N">N Ghazzali</name></author><author><name sortKey="Boiteau, V" uniqKey="Boiteau V">V Boiteau</name></author><author><name sortKey="Niknafs, A" uniqKey="Niknafs A">A Niknafs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Churpek, Mm" uniqKey="Churpek M">MM Churpek</name></author><author><name sortKey="Yuen, Tc" uniqKey="Yuen T">TC Yuen</name></author><author><name sortKey="Winslow, C" uniqKey="Winslow C">C Winslow</name></author><author><name sortKey="Meltzer, Do" uniqKey="Meltzer D">DO Meltzer</name></author><author><name sortKey="Kattan, Mw" uniqKey="Kattan M">MW Kattan</name></author><author><name sortKey="Edelson, Dp" uniqKey="Edelson D">DP Edelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Hr" uniqKey="Wong H">HR Wong</name></author><author><name sortKey="Lindsell, Cj" uniqKey="Lindsell C">CJ Lindsell</name></author><author><name sortKey="Pettila, V" uniqKey="Pettila V">V Pettila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Lm" uniqKey="Brown L">LM Brown</name></author><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author><author><name sortKey="Brower, Rg" uniqKey="Brower R">RG Brower</name></author><author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name></author><author><name sortKey="Checkley, W" uniqKey="Checkley W">W Checkley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wenzel, Se" uniqKey="Wenzel S">SE Wenzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howard, R" uniqKey="Howard R">R Howard</name></author><author><name sortKey="Rattray, M" uniqKey="Rattray M">M Rattray</name></author><author><name sortKey="Prosperi, M" uniqKey="Prosperi M">M Prosperi</name></author><author><name sortKey="Custovic, A" uniqKey="Custovic A">A Custovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reilly, Jp" uniqKey="Reilly J">JP Reilly</name></author><author><name sortKey="Bellamy, S" uniqKey="Bellamy S">S Bellamy</name></author><author><name sortKey="Shashaty, Mgs" uniqKey="Shashaty M">MGS Shashaty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A Agrawal</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author><author><name sortKey="Kangelaris, Kn" uniqKey="Kangelaris K">KN Kangelaris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Gallagher, D" uniqKey="Gallagher D">D Gallagher</name></author><author><name sortKey="Abbott, J" uniqKey="Abbott J">J Abbott</name></author><author><name sortKey="Thompson, Bt" uniqKey="Thompson B">BT Thompson</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fremont, Rd" uniqKey="Fremont R">RD Fremont</name></author><author><name sortKey="Koyama, T" uniqKey="Koyama T">T Koyama</name></author><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Nj" uniqKey="Meyer N">NJ Meyer</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Feng, R" uniqKey="Feng R">R Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westra, Hj" uniqKey="Westra H">HJ Westra</name></author><author><name sortKey="Peters, Mj" uniqKey="Peters M">MJ Peters</name></author><author><name sortKey="Esko, T" uniqKey="Esko T">T Esko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, K" uniqKey="Imai K">K Imai</name></author><author><name sortKey="Keele, L" uniqKey="Keele L">L Keele</name></author><author><name sortKey="Tingley, D" uniqKey="Tingley D">D Tingley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Su, L" uniqKey="Su L">L Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Tejera, P" uniqKey="Tejera P">P Tejera</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, J" uniqKey="Cohen J">J Cohen</name></author><author><name sortKey="Pertsemlidis, A" uniqKey="Pertsemlidis A">A Pertsemlidis</name></author><author><name sortKey="Kotowski, Ik" uniqKey="Kotowski I">IK Kotowski</name></author><author><name sortKey="Graham, R" uniqKey="Graham R">R Graham</name></author><author><name sortKey="Garcia, Ck" uniqKey="Garcia C">CK Garcia</name></author><author><name sortKey="Hobbs, Hh" uniqKey="Hobbs H">HH Hobbs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Jc" uniqKey="Cohen J">JC Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huh, D" uniqKey="Huh D">D Huh</name></author><author><name sortKey="Leslie, Dc" uniqKey="Leslie D">DC Leslie</name></author><author><name sortKey="Matthews, Bd" uniqKey="Matthews B">BD Matthews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cypel, M" uniqKey="Cypel M">M Cypel</name></author><author><name sortKey="Yeung, Jc" uniqKey="Yeung J">JC Yeung</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaney, J" uniqKey="Chaney J">J Chaney</name></author><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name></author><author><name sortKey="Cantu, E" uniqKey="Cantu E">E Cantu</name></author><author><name sortKey="Van Berkel, V" uniqKey="Van Berkel V">V van Berkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauley, Df" uniqKey="Mcauley D">DF McAuley</name></author><author><name sortKey="Curley, Gf" uniqKey="Curley G">GF Curley</name></author><author><name sortKey="Hamid, Ui" uniqKey="Hamid U">UI Hamid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Jw" uniqKey="Lee J">JW Lee</name></author><author><name sortKey="Krasnodembskaya, A" uniqKey="Krasnodembskaya A">A Krasnodembskaya</name></author><author><name sortKey="Mckenna, Dh" uniqKey="Mckenna D">DH McKenna</name></author><author><name sortKey="Song, Y" uniqKey="Song Y">Y Song</name></author><author><name sortKey="Abbott, J" uniqKey="Abbott J">J Abbott</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gores, Km" uniqKey="Gores K">KM Gores</name></author><author><name sortKey="Delsing, As" uniqKey="Delsing A">AS Delsing</name></author><author><name sortKey="Kraus, Sj" uniqKey="Kraus S">SJ Kraus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jinek, M" uniqKey="Jinek M">M Jinek</name></author><author><name sortKey="Chylinski, K" uniqKey="Chylinski K">K Chylinski</name></author><author><name sortKey="Fonfara, I" uniqKey="Fonfara I">I Fonfara</name></author><author><name sortKey="Hauer, M" uniqKey="Hauer M">M Hauer</name></author><author><name sortKey="Doudna, Ja" uniqKey="Doudna J">JA Doudna</name></author><author><name sortKey="Charpentier, E" uniqKey="Charpentier E">E Charpentier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flaherty, Kt" uniqKey="Flaherty K">KT Flaherty</name></author><author><name sortKey="Robert, C" uniqKey="Robert C">C Robert</name></author><author><name sortKey="Hersey, P" uniqKey="Hersey P">P Hersey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kris, Mg" uniqKey="Kris M">MG Kris</name></author><author><name sortKey="Johnson, Be" uniqKey="Johnson B">BE Johnson</name></author><author><name sortKey="Berry, Ld" uniqKey="Berry L">LD Berry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortega, Hg" uniqKey="Ortega H">HG Ortega</name></author><author><name sortKey="Liu, Mc" uniqKey="Liu M">MC Liu</name></author><author><name sortKey="Pavord, Id" uniqKey="Pavord I">ID Pavord</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freidlin, B" uniqKey="Freidlin B">B Freidlin</name></author><author><name sortKey="Korn, El" uniqKey="Korn E">EL Korn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehta, C" uniqKey="Mehta C">C Mehta</name></author><author><name sortKey="Schafer, H" uniqKey="Schafer H">H Schafer</name></author><author><name sortKey="Daniel, H" uniqKey="Daniel H">H Daniel</name></author><author><name sortKey="Irle, S" uniqKey="Irle S">S Irle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geiss, Gk" uniqKey="Geiss G">GK Geiss</name></author><author><name sortKey="Bumgarner, Re" uniqKey="Bumgarner R">RE Bumgarner</name></author><author><name sortKey="Birditt, B" uniqKey="Birditt B">B Birditt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cuenca, Ag" uniqKey="Cuenca A">AG Cuenca</name></author><author><name sortKey="Gentile, Lf" uniqKey="Gentile L">LF Gentile</name></author><author><name sortKey="Lopez, Mc" uniqKey="Lopez M">MC Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calfee, Cs" uniqKey="Calfee C">CS Calfee</name></author><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author><author><name sortKey="Eisner, Md" uniqKey="Eisner M">MD Eisner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name></author><author><name sortKey="Mcauley, Df" uniqKey="Mcauley D">DF McAuley</name></author><author><name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet Respir Med</journal-id><journal-id journal-id-type="iso-abbrev">Lancet Respir Med</journal-id><journal-title-group><journal-title>The Lancet. Respiratory Medicine</journal-title></journal-title-group><issn pub-type="ppub">2213-2600</issn><issn pub-type="epub">2213-2619</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28664850</article-id><article-id pub-id-type="pmc">7103930</article-id><article-id pub-id-type="publisher-id">S2213-2600(17)30187-X</article-id><article-id pub-id-type="doi">10.1016/S2213-2600(17)30187-X</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>Meyer</surname><given-names>Nuala J</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au20"><name><surname>Calfee</surname><given-names>Carolyn S</given-names></name><degrees>Dr</degrees><degrees>MD</degrees><email>carolyn.calfee@ucsf.edu</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</aff><aff id="aff2"><label>b</label>Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA, USA</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Dr Carolyn S Calfee, Department of Medicine, University of California, San Francisco, CA 94143–0111, USA <email>carolyn.calfee@ucsf.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>26</day><month>5</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>6</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>26</day><month>5</month><year>2017</year></pub-date><volume>5</volume><issue>6</issue><fpage>512</fpage><lpage>523</lpage><permissions><copyright-statement>© 2017 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ceab10"><title>Summary</title><p>In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression patterns in plasma and bronchoalveolar lavage fluid from patients with ARDS. Despite this effort, however, pharmacological options for ARDS remain scarce. Frequently cited reasons for this absence of specific drug therapies include the heterogeneity of patients with ARDS, the potential for a differential response to drugs, and the possibility that the wrong targets have been studied. Advances in applied biomolecular technology and bioinformatics have enabled breakthroughs for other complex traits, such as cardiovascular disease or asthma, particularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern indicates a patient's likelihood of responding to a treatment, has been pursued. In this Review, we consider the biological and analytical techniques that could facilitate a precision medicine approach for ARDS.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Meyer, Nuala J" sort="Meyer, Nuala J" uniqKey="Meyer N" first="Nuala J" last="Meyer">Nuala J. Meyer</name></region><name sortKey="Calfee, Carolyn S" sort="Calfee, Carolyn S" uniqKey="Calfee C" first="Carolyn S" last="Calfee">Carolyn S. Calfee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000867 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000867 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:7103930
|texte= Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:28664850" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |