COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
Identifieur interne : 000655 ( Main/Exploration ); précédent : 000654; suivant : 000656COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
Auteurs : Dan Zhou [République populaire de Chine] ; Sheng-Ming Dai [République populaire de Chine] ; Qiang Tong [République populaire de Chine]Source :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 2020.
Abstract
A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression.
Url:
DOI: 10.1093/jac/dkaa114
PubMed: 32196083
PubMed Central: 7184499
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Dai, Sheng Ming" sort="Dai, Sheng Ming" uniqKey="Dai S" first="Sheng-Ming" last="Dai">Sheng-Ming Dai</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tong, Qiang" sort="Tong, Qiang" uniqKey="Tong Q" first="Qiang" last="Tong">Qiang Tong</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de 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Research and Innovation, Shanghai Pudong Hospital, Fudan University</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dai, Sheng Ming" sort="Dai, Sheng Ming" uniqKey="Dai S" first="Sheng-Ming" last="Dai">Sheng-Ming Dai</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tong, Qiang" sort="Tong, Qiang" uniqKey="Tong Q" first="Qiang" last="Tong">Qiang Tong</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Chen, P" uniqKey="Chen P">P Chen</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Hu, C" uniqKey="Hu C">C Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimabukuro Vornhagen, A" uniqKey="Shimabukuro Vornhagen A">A Shimabukuro-Vornhagen</name></author><author><name sortKey="Godel, P" uniqKey="Godel P">P Godel</name></author><author><name sortKey="Subklewe, M" uniqKey="Subklewe M">M Subklewe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, Tp" uniqKey="Sheahan T">TP Sheahan</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz Irastorza, G" uniqKey="Ruiz Irastorza G">G Ruiz-Irastorza</name></author><author><name sortKey="Ramos Casals, M" uniqKey="Ramos Casals M">M Ramos-Casals</name></author><author><name sortKey="Brito Zeron, P" uniqKey="Brito Zeron P">P Brito-Zeron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotteau, V" uniqKey="Lotteau V">V Lotteau</name></author><author><name sortKey="Teyton, L" uniqKey="Teyton L">L Teyton</name></author><author><name sortKey="Peleraux, A" uniqKey="Peleraux A">A Peleraux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Sf" uniqKey="Wu S">SF Wu</name></author><author><name sortKey="Chang, Cb" uniqKey="Chang C">CB Chang</name></author><author><name sortKey="Hsu, Jm" uniqKey="Hsu J">JM Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Borne, Be" uniqKey="Van Den Borne B">BE van den Borne</name></author><author><name sortKey="Dijkmans, Ba" uniqKey="Dijkmans B">BA Dijkmans</name></author><author><name sortKey="De Rooij, Hh" uniqKey="De Rooij H">HH de Rooij</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuznik, A" uniqKey="Kuznik A">A Kuznik</name></author><author><name sortKey="Bencina, M" uniqKey="Bencina M">M Bencina</name></author><author><name sortKey="Svajger, U" uniqKey="Svajger U">U Svajger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ewald, Se" uniqKey="Ewald S">SE Ewald</name></author><author><name sortKey="Lee, Bl" uniqKey="Lee B">BL Lee</name></author><author><name sortKey="Lau, L" uniqKey="Lau L">L Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, H" uniqKey="Hacker H">H Hacker</name></author><author><name sortKey="Mischak, H" uniqKey="Mischak H">H Mischak</name></author><author><name sortKey="Miethke, T" uniqKey="Miethke T">T Miethke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vollmer, J" uniqKey="Vollmer J">J Vollmer</name></author><author><name sortKey="Tluk, S" uniqKey="Tluk S">S Tluk</name></author><author><name sortKey="Schmitz, C" uniqKey="Schmitz C">C Schmitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="An, J" uniqKey="An J">J An</name></author><author><name sortKey="Woodward, Jj" uniqKey="Woodward J">JJ Woodward</name></author><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T Sasaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, Mj" uniqKey="Vincent M">MJ Vincent</name></author><author><name sortKey="Bergeron, E" uniqKey="Bergeron E">E Bergeron</name></author><author><name sortKey="Benjannet, S" uniqKey="Benjannet S">S Benjannet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR. 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