COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
Identifieur interne : 000B73 ( Ncbi/Merge ); précédent : 000B72; suivant : 000B74COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
Auteurs : Dan Zhou [République populaire de Chine] ; Sheng-Ming Dai [République populaire de Chine] ; Qiang Tong [République populaire de Chine]Source :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 2020.
Abstract
A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression.
Url:
DOI: 10.1093/jac/dkaa114
PubMed: 32196083
PubMed Central: 7184499
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000933
- to stream Pmc, to step Curation: 000933
- to stream Pmc, to step Checkpoint: 000560
Links to Exploration step
PMC:7184499Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression</title><author><name sortKey="Zhou, Dan" sort="Zhou, Dan" uniqKey="Zhou D" first="Dan" last="Zhou">Dan Zhou</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff1"><institution>Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff2"><institution>Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dai, Sheng Ming" sort="Dai, Sheng Ming" uniqKey="Dai S" first="Sheng-Ming" last="Dai">Sheng-Ming Dai</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tong, Qiang" sort="Tong, Qiang" uniqKey="Tong Q" first="Qiang" last="Tong">Qiang Tong</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32196083</idno><idno type="pmc">7184499</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184499</idno><idno type="RBID">PMC:7184499</idno><idno type="doi">10.1093/jac/dkaa114</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000933</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000933</idno><idno type="wicri:Area/Pmc/Curation">000933</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000933</idno><idno type="wicri:Area/Pmc/Checkpoint">000560</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000560</idno><idno type="wicri:Area/Ncbi/Merge">000B73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression</title><author><name sortKey="Zhou, Dan" sort="Zhou, Dan" uniqKey="Zhou D" first="Dan" last="Zhou">Dan Zhou</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff1"><institution>Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff2"><institution>Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dai, Sheng Ming" sort="Dai, Sheng Ming" uniqKey="Dai S" first="Sheng-Ming" last="Dai">Sheng-Ming Dai</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tong, Qiang" sort="Tong, Qiang" uniqKey="Tong Q" first="Qiang" last="Tong">Qiang Tong</name><affiliation wicri:level="1"><nlm:aff id="dkaa114-aff3"><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Chen, P" uniqKey="Chen P">P Chen</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Hu, C" uniqKey="Hu C">C Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimabukuro Vornhagen, A" uniqKey="Shimabukuro Vornhagen A">A Shimabukuro-Vornhagen</name></author><author><name sortKey="Godel, P" uniqKey="Godel P">P Godel</name></author><author><name sortKey="Subklewe, M" uniqKey="Subklewe M">M Subklewe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, Tp" uniqKey="Sheahan T">TP Sheahan</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz Irastorza, G" uniqKey="Ruiz Irastorza G">G Ruiz-Irastorza</name></author><author><name sortKey="Ramos Casals, M" uniqKey="Ramos Casals M">M Ramos-Casals</name></author><author><name sortKey="Brito Zeron, P" uniqKey="Brito Zeron P">P Brito-Zeron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotteau, V" uniqKey="Lotteau V">V Lotteau</name></author><author><name sortKey="Teyton, L" uniqKey="Teyton L">L Teyton</name></author><author><name sortKey="Peleraux, A" uniqKey="Peleraux A">A Peleraux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Sf" uniqKey="Wu S">SF Wu</name></author><author><name sortKey="Chang, Cb" uniqKey="Chang C">CB Chang</name></author><author><name sortKey="Hsu, Jm" uniqKey="Hsu J">JM Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Borne, Be" uniqKey="Van Den Borne B">BE van den Borne</name></author><author><name sortKey="Dijkmans, Ba" uniqKey="Dijkmans B">BA Dijkmans</name></author><author><name sortKey="De Rooij, Hh" uniqKey="De Rooij H">HH de Rooij</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuznik, A" uniqKey="Kuznik A">A Kuznik</name></author><author><name sortKey="Bencina, M" uniqKey="Bencina M">M Bencina</name></author><author><name sortKey="Svajger, U" uniqKey="Svajger U">U Svajger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ewald, Se" uniqKey="Ewald S">SE Ewald</name></author><author><name sortKey="Lee, Bl" uniqKey="Lee B">BL Lee</name></author><author><name sortKey="Lau, L" uniqKey="Lau L">L Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, H" uniqKey="Hacker H">H Hacker</name></author><author><name sortKey="Mischak, H" uniqKey="Mischak H">H Mischak</name></author><author><name sortKey="Miethke, T" uniqKey="Miethke T">T Miethke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vollmer, J" uniqKey="Vollmer J">J Vollmer</name></author><author><name sortKey="Tluk, S" uniqKey="Tluk S">S Tluk</name></author><author><name sortKey="Schmitz, C" uniqKey="Schmitz C">C Schmitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="An, J" uniqKey="An J">J An</name></author><author><name sortKey="Woodward, Jj" uniqKey="Woodward J">JJ Woodward</name></author><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T Sasaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, Mj" uniqKey="Vincent M">MJ Vincent</name></author><author><name sortKey="Bergeron, E" uniqKey="Bergeron E">E Bergeron</name></author><author><name sortKey="Benjannet, S" uniqKey="Benjannet S">S Benjannet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR. Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrezenmeier, E" uniqKey="Schrezenmeier E">E Schrezenmeier</name></author><author><name sortKey="Dorner, T" uniqKey="Dorner T">T. Dorner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Bari, Maa" uniqKey="Al Bari M">MAA. Al-Bari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz Irastorza, G" uniqKey="Ruiz Irastorza G">G Ruiz-Irastorza</name></author><author><name sortKey="Olivares, N" uniqKey="Olivares N">N Olivares</name></author><author><name sortKey="Ruiz Arruza, I" uniqKey="Ruiz Arruza I">I Ruiz-Arruza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srinivasa, A" uniqKey="Srinivasa A">A Srinivasa</name></author><author><name sortKey="Tosounidou, S" uniqKey="Tosounidou S">S Tosounidou</name></author><author><name sortKey="Gordon, C" uniqKey="Gordon C">C. Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jorge, A" uniqKey="Jorge A">A Jorge</name></author><author><name sortKey="Ung, C" uniqKey="Ung C">C Ung</name></author><author><name sortKey="Young, Lh" uniqKey="Young L">LH Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Izmirly, Pm" uniqKey="Izmirly P">PM Izmirly</name></author><author><name sortKey="Costedoat Chalumeau, N" uniqKey="Costedoat Chalumeau N">N Costedoat-Chalumeau</name></author><author><name sortKey="Pisoni, Cn" uniqKey="Pisoni C">CN Pisoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lisney, Ar" uniqKey="Lisney A">AR Lisney</name></author><author><name sortKey="Szelinski, F" uniqKey="Szelinski F">F Szelinski</name></author><author><name sortKey="Reiter, K" uniqKey="Reiter K">K Reiter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furst, De" uniqKey="Furst D">DE Furst</name></author><author><name sortKey="Lindsley, H" uniqKey="Lindsley H">H Lindsley</name></author><author><name sortKey="Baethge, B" uniqKey="Baethge B">B Baethge</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Antimicrob Chemother</journal-id><journal-id journal-id-type="iso-abbrev">J. Antimicrob. Chemother</journal-id><journal-id journal-id-type="publisher-id">jac</journal-id><journal-title-group><journal-title>Journal of Antimicrobial Chemotherapy</journal-title></journal-title-group><issn pub-type="ppub">0305-7453</issn><issn pub-type="epub">1460-2091</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32196083</article-id><article-id pub-id-type="pmc">7184499</article-id><article-id pub-id-type="doi">10.1093/jac/dkaa114</article-id><article-id pub-id-type="publisher-id">dkaa114</article-id><article-categories><subj-group subj-group-type="heading"><subject>Leading Article</subject></subj-group></article-categories><title-group><article-title>COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2306-3456</contrib-id><name><surname>Zhou</surname><given-names>Dan</given-names></name><xref ref-type="aff" rid="dkaa114-aff1">d1</xref><xref ref-type="aff" rid="dkaa114-aff2">d2</xref></contrib><contrib contrib-type="author"><name><surname>Dai</surname><given-names>Sheng-Ming</given-names></name><xref ref-type="aff" rid="dkaa114-aff3">d3</xref></contrib><contrib contrib-type="author"><name><surname>Tong</surname><given-names>Qiang</given-names></name><xref ref-type="aff" rid="dkaa114-aff3">d3</xref><xref ref-type="corresp" rid="dkaa114-cor1"></xref><pmc-comment>jasontong1985@outlook.com </pmc-comment>
</contrib></contrib-group><aff id="dkaa114-aff1"><label>d1</label><institution>Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University</institution>, Shanghai,<country country="CN">China</country></aff><aff id="dkaa114-aff2"><label>d2</label><institution>Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University</institution>, Shanghai,<country country="CN">China</country></aff><aff id="dkaa114-aff3"><label>d3</label><institution>Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital</institution>, Shanghai,<country country="CN">China</country></aff><author-notes><corresp id="dkaa114-cor1">Corresponding author. E-mail: <email>jasontong1985@outlook.com</email></corresp></author-notes><pub-date pub-type="epub" iso-8601-date="2020-03-20"><day>20</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<elocation-id>dkaa114</elocation-id><permissions><copyright-statement>© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.</copyright-statement><copyright-year>2020</copyright-year><license license-type="publisher-standard" xlink:href="https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"><license-p>This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (<ext-link ext-link-type="uri" xlink:href="https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model">https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model</ext-link>)</license-p></license><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="dkaa114.pdf"></self-uri><abstract><title>Abstract</title><p>A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression.</p></abstract><counts><page-count count="4"></page-count></counts><custom-meta-group><custom-meta><meta-name>article-lifecycle</meta-name><meta-value>PAP</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Dan" sort="Zhou, Dan" uniqKey="Zhou D" first="Dan" last="Zhou">Dan Zhou</name></noRegion><name sortKey="Dai, Sheng Ming" sort="Dai, Sheng Ming" uniqKey="Dai S" first="Sheng-Ming" last="Dai">Sheng-Ming Dai</name><name sortKey="Tong, Qiang" sort="Tong, Qiang" uniqKey="Tong Q" first="Qiang" last="Tong">Qiang Tong</name><name sortKey="Zhou, Dan" sort="Zhou, Dan" uniqKey="Zhou D" first="Dan" last="Zhou">Dan Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B73 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000B73 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:7184499
|texte= COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:32196083" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |