Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans
Identifieur interne : 000044 ( Istex/Corpus ); précédent : 000043; suivant : 000045Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans
Auteurs : T. Mizutani ; S. Fukushi ; T. Kenri ; Y. Sasaki ; K. Ishii ; D. Endoh ; A. Zamoto ; M. Saijo ; I. Kurane ; S. MorikawaSource :
- Archives of Virology [ 0304-8608 ] ; 2007-05-01.
Abstract
Summary.: We previously reported that cells with persistent severe acute respiratory syndrome coronavirus (SARS-CoV) infection were established after apoptotic events. In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.
Url:
DOI: 10.1007/s00705-006-0924-7
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Sasaki</name><affiliation><mods:affiliation>Department of Bacteriology 2, National Institute of Infectious Diseases, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ishii, K" sort="Ishii, K" uniqKey="Ishii K" first="K." last="Ishii">K. Ishii</name><affiliation><mods:affiliation>Department of Virology 2, National Institute of Infectious Diseases, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Endoh, D" sort="Endoh, D" uniqKey="Endoh D" first="D." last="Endoh">D. Endoh</name><affiliation><mods:affiliation>Laboratory of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan</mods:affiliation></affiliation></author><author><name sortKey="Zamoto, A" sort="Zamoto, A" uniqKey="Zamoto A" first="A." last="Zamoto">A. Zamoto</name><affiliation><mods:affiliation>Division of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Saijo, M" sort="Saijo, M" uniqKey="Saijo M" first="M." last="Saijo">M. Saijo</name><affiliation><mods:affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kurane, I" sort="Kurane, I" uniqKey="Kurane I" first="I." last="Kurane">I. Kurane</name><affiliation><mods:affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Morikawa, S" sort="Morikawa, S" uniqKey="Morikawa S" first="S." last="Morikawa">S. 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In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>T. Mizutani</name><affiliations><json:string>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>S. 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Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. 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In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.</p></abstract><textClass><keywords scheme="Journal-Subject-Group"><list><label>B</label><item><term>Biomedicine</term></item><label>B22003</label><item><term>Virology</term></item><label>B16003</label><item><term>Medical Microbiology</term></item><label>H33096</label><item><term>Infectious Diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-06-15">Created</change><change when="2007-05-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-SBHJ7GG3-L/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" 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DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Ishii</FamilyName></AuthorName></Author><Author AffiliationIDS="A5"><AuthorName DisplayOrder="Western"><GivenName>D.</GivenName><FamilyName>Endoh</FamilyName></AuthorName></Author><Author AffiliationIDS="A4"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Zamoto</FamilyName></AuthorName></Author><Author AffiliationIDS="A1"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Saijo</FamilyName></AuthorName></Author><Author AffiliationIDS="A1"><AuthorName DisplayOrder="Western"><GivenName>I.</GivenName><FamilyName>Kurane</FamilyName></AuthorName></Author><Author AffiliationIDS="A1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Morikawa</FamilyName></AuthorName></Author><Affiliation ID="A1"><OrgDivision>Department of Virology 1</OrgDivision><OrgName>National Institute of Infectious Diseases</OrgName><OrgAddress><City>Tokyo</City><Country Code="JP">Japan</Country></OrgAddress></Affiliation><Affiliation ID="A2"><OrgDivision>Department of Bacteriology 2</OrgDivision><OrgName>National Institute of Infectious Diseases</OrgName><OrgAddress><City>Tokyo</City><Country Code="JP">Japan</Country></OrgAddress></Affiliation><Affiliation ID="A3"><OrgDivision>Department of Virology 2</OrgDivision><OrgName>National Institute of Infectious Diseases</OrgName><OrgAddress><City>Tokyo</City><Country Code="JP">Japan</Country></OrgAddress></Affiliation><Affiliation ID="A4"><OrgDivision>Division of Experimental Animal Research</OrgDivision><OrgName>National Institute of Infectious Diseases</OrgName><OrgAddress><City>Tokyo</City><Country Code="JP">Japan</Country></OrgAddress></Affiliation><Affiliation ID="A5"><OrgDivision>Laboratory of Veterinary Radiology, School of Veterinary Medicine</OrgDivision><OrgName>Rakuno Gakuen University</OrgName><OrgAddress><City>Ebetsu</City><Country Code="JP">Japan</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary.</Heading><Para TextBreak="No">We previously reported that cells with persistent severe acute respiratory syndrome coronavirus (SARS-CoV) infection were established after apoptotic events. In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and <Emphasis Type="Italic">Mycoplasma fermentans</Emphasis> on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. <Emphasis Type="Italic">M. fermentans</Emphasis> induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in <Emphasis Type="Italic">M. fermentans</Emphasis>-infected cells, indicating that they were primed for apoptosis. These results indicated that <Emphasis Type="Italic">M. fermentans</Emphasis> enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans </title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Mizutani</namePart><affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Fukushi</namePart><affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Kenri</namePart><affiliation>Department of Bacteriology 2, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Sasaki</namePart><affiliation>Department of Bacteriology 2, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ishii</namePart><affiliation>Department of Virology 2, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Endoh</namePart><affiliation>Laboratory of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Zamoto</namePart><affiliation>Division of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Saijo</namePart><affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Kurane</namePart><affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Morikawa</namePart><affiliation>Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Report" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">2006-06-15</dateCreated><dateIssued encoding="w3cdtf">2007-05-01</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary.: We previously reported that cells with persistent severe acute respiratory syndrome coronavirus (SARS-CoV) infection were established after apoptotic events. In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.</abstract><note>Brief Report</note><relatedItem type="host"><titleInfo><title>Archives of Virology</title><subTitle>Official Journal of the Virology Division of the International Union of Microbiological Societies</subTitle></titleInfo><titleInfo type="abbreviated"><title>Arch Virol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2007-05-01</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="B">Biomedicine</topic><topic authority="SpringerSubjectCodes" authorityURI="B22003">Virology</topic><topic authority="SpringerSubjectCodes" authorityURI="B16003">Medical Microbiology</topic><topic authority="SpringerSubjectCodes" authorityURI="H33096">Infectious Diseases</topic></subject><identifier type="ISSN">0304-8608</identifier><identifier type="eISSN">1432-8798</identifier><identifier type="JournalID">705</identifier><identifier type="JournalSPIN">30024806</identifier><identifier type="IssueArticleCount">20</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2007</date><detail type="volume"><number>152</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="pages"><start>1019</start><end>1025</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2007</recordOrigin></recordInfo></relatedItem><identifier type="istex">4DB8CE5C3C538EFD4585E9B74149813A02CAE0DC</identifier><identifier type="ark">ark:/67375/VQC-SBHJ7GG3-L</identifier><identifier type="DOI">10.1007/s00705-006-0924-7</identifier><identifier type="ArticleID">924</identifier><identifier type="ArticleID">Art1</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2007</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2007</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-SBHJ7GG3-L/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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