Regulation of iron homeostasis by microRNAs
Identifieur interne : 000043 ( Istex/Corpus ); précédent : 000042; suivant : 000044Regulation of iron homeostasis by microRNAs
Auteurs : Mirco Castoldi ; Martina U. MuckenthalerSource :
- Cellular and Molecular Life Sciences [ 1420-682X ] ; 2012-12-01.
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Abstract
Abstract: Iron homeostasis is maintained at the cellular and systemic levels to assure adequate iron supply while preventing iron overload. The identification of genes mutated in patients with iron-related disorders or animal models with imbalances of iron homeostasis gave insight into the molecular mechanisms underlying processes critical for balancing iron levels, such as iron uptake, storage, export, and monitoring of available iron. MicroRNAs control genes involved in some of these processes adding an additional level of complexity to the regulation of iron metabolism. This review summarizes recent advances how miRNAs regulate iron homeostasis.
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DOI: 10.1007/s00018-012-1031-4
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ISTEX:4F45C298292EC1522C6D3E713CA185EC6FDA7C19Le document en format XML
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The identification of genes mutated in patients with iron-related disorders or animal models with imbalances of iron homeostasis gave insight into the molecular mechanisms underlying processes critical for balancing iron levels, such as iron uptake, storage, export, and monitoring of available iron. MicroRNAs control genes involved in some of these processes adding an additional level of complexity to the regulation of iron metabolism. This review summarizes recent advances how miRNAs regulate iron homeostasis.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Iron homeostasis</Keyword><Keyword>MicroRNA</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Regulation of iron homeostasis by microRNAs</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Regulation of iron homeostasis by microRNAs</title></titleInfo><name type="personal"><namePart type="given">Mirco</namePart><namePart type="family">Castoldi</namePart><affiliation>Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, 69120, Heidelberg, Germany</affiliation><affiliation>Molecular Medicine Partnership Unit, University of Heidelberg, 69120, Heidelberg, Germany</affiliation><affiliation>E-mail: Castoldi@embl.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Martina</namePart><namePart type="given">U.</namePart><namePart type="family">Muckenthaler</namePart><affiliation>Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, 69120, Heidelberg, Germany</affiliation><affiliation>Molecular Medicine Partnership Unit, University of Heidelberg, 69120, Heidelberg, Germany</affiliation><affiliation>E-mail: Martina.Muckenthaler@med.uni-heidelberg.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>SP Birkhäuser Verlag Basel</publisher><place><placeTerm type="text">Basel</placeTerm></place><dateCreated encoding="w3cdtf">2012-03-27</dateCreated><dateIssued encoding="w3cdtf">2012-12-01</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Iron homeostasis is maintained at the cellular and systemic levels to assure adequate iron supply while preventing iron overload. 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