Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans
Identifieur interne : 000D49 ( Istex/Checkpoint ); précédent : 000D48; suivant : 000D50Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans
Auteurs : T. Mizutani [Japon] ; S. Fukushi [Japon] ; T. Kenri [Japon] ; Y. Sasaki [Japon] ; K. Ishii [Japon] ; D. Endoh [Japon] ; A. Zamoto [Japon] ; M. Saijo [Japon] ; I. Kurane [Japon] ; S. Morikawa [Japon]Source :
- Archives of Virology [ 0304-8608 ] ; 2007-05-01.
Abstract
Summary.: We previously reported that cells with persistent severe acute respiratory syndrome coronavirus (SARS-CoV) infection were established after apoptotic events. In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.
Url:
DOI: 10.1007/s00705-006-0924-7
Affiliations:
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<front><div type="abstract" xml:lang="en">Summary.: We previously reported that cells with persistent severe acute respiratory syndrome coronavirus (SARS-CoV) infection were established after apoptotic events. In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.</div>
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