Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients.
Identifieur interne : 002C15 ( PubMed/Curation ); précédent : 002C14; suivant : 002C16Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients.
Auteurs : Rong Zeng [République populaire de Chine] ; Rui-Fu Yang ; Mu-De Shi ; Man-Rong Jiang ; You-Hua Xie ; Hong-Qiang Ruan ; Xiao-Sheng Jiang ; Lv Shi ; Hu Zhou ; Lei Zhang ; Xiao-Dong Wu ; Ying Lin ; Yong-Yong Ji ; Lei Xiong ; Yan Jin ; Er-Hei Dai ; Xiao-Yi Wang ; Bin-Ying Si ; Jin Wang ; Hong-Xia Wang ; Cui-E Wang ; Yong-Hua Gan ; Yu-Chuan Li ; Ju-Tian Cao ; Jiang-Ping Zuo ; Shi-Fang Shan ; En Xie ; Song-Hua Chen ; Zhi-Qin Jiang ; Xi Zhang ; Yuan Wang ; Gang Pei ; Bing Sun ; Jia-Rui WuSource :
- Journal of molecular biology [ 0022-2836 ] ; 2004.
Descripteurs français
- KwdFr :
- Analyse de séquence de protéine, Animaux, Cellules Vero, Disulfures (métabolisme), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (métabolisme), Humains, Phylogénie, Protéines de l'enveloppe virale (métabolisme), Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Protéomique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : Protéines virales, Virus du SRAS.
- métabolisme : Disulfures, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines virales, Virus du SRAS.
- Analyse de séquence de protéine, Animaux, Cellules Vero, Glycoprotéine de spicule des coronavirus, Humains, Phylogénie, Protéines virales, Protéomique, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Disulfides (metabolism), Humans, Membrane Glycoproteins (metabolism), Phylogeny, Proteomics, SARS Virus (chemistry), SARS Virus (genetics), SARS Virus (metabolism), Sequence Analysis, Protein, Spike Glycoprotein, Coronavirus, Vero Cells, Viral Envelope Proteins (metabolism), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , chemistry : Viral Proteins.
- chemical , genetics : Viral Proteins.
- chemical , metabolism : Disulfides, Membrane Glycoproteins, Viral Envelope Proteins, Viral Proteins.
- chemistry : SARS Virus.
- genetics : SARS Virus.
- metabolism : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Phylogeny, Proteomics, Sequence Analysis, Protein, Spike Glycoprotein, Coronavirus, Vero Cells.
Abstract
Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment.
DOI: 10.1016/j.jmb.2004.06.016
PubMed: 15312778
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Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Rui Fu" sort="Yang, Rui Fu" uniqKey="Yang R" first="Rui-Fu" last="Yang">Rui-Fu Yang</name></author><author><name sortKey="Shi, Mu De" sort="Shi, Mu De" uniqKey="Shi M" first="Mu-De" last="Shi">Mu-De Shi</name></author><author><name sortKey="Jiang, Man Rong" sort="Jiang, Man Rong" uniqKey="Jiang M" first="Man-Rong" last="Jiang">Man-Rong Jiang</name></author><author><name sortKey="Xie, You Hua" sort="Xie, You Hua" uniqKey="Xie Y" first="You-Hua" last="Xie">You-Hua Xie</name></author><author><name sortKey="Ruan, Hong Qiang" sort="Ruan, Hong Qiang" uniqKey="Ruan H" first="Hong-Qiang" last="Ruan">Hong-Qiang Ruan</name></author><author><name sortKey="Jiang, Xiao Sheng" sort="Jiang, Xiao Sheng" uniqKey="Jiang X" first="Xiao-Sheng" last="Jiang">Xiao-Sheng Jiang</name></author><author><name sortKey="Shi, Lv" sort="Shi, Lv" uniqKey="Shi L" first="Lv" last="Shi">Lv Shi</name></author><author><name sortKey="Zhou, Hu" sort="Zhou, Hu" uniqKey="Zhou H" first="Hu" last="Zhou">Hu Zhou</name></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name></author><author><name sortKey="Wu, Xiao Dong" sort="Wu, Xiao Dong" uniqKey="Wu X" first="Xiao-Dong" last="Wu">Xiao-Dong Wu</name></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name></author><author><name sortKey="Ji, Yong Yong" sort="Ji, Yong Yong" uniqKey="Ji Y" first="Yong-Yong" last="Ji">Yong-Yong Ji</name></author><author><name sortKey="Xiong, Lei" sort="Xiong, Lei" uniqKey="Xiong L" first="Lei" 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last="Gan">Yong-Hua Gan</name></author><author><name sortKey="Li, Yu Chuan" sort="Li, Yu Chuan" uniqKey="Li Y" first="Yu-Chuan" last="Li">Yu-Chuan Li</name></author><author><name sortKey="Cao, Ju Tian" sort="Cao, Ju Tian" uniqKey="Cao J" first="Ju-Tian" last="Cao">Ju-Tian Cao</name></author><author><name sortKey="Zuo, Jiang Ping" sort="Zuo, Jiang Ping" uniqKey="Zuo J" first="Jiang-Ping" last="Zuo">Jiang-Ping Zuo</name></author><author><name sortKey="Shan, Shi Fang" sort="Shan, Shi Fang" uniqKey="Shan S" first="Shi-Fang" last="Shan">Shi-Fang Shan</name></author><author><name sortKey="Xie, En" sort="Xie, En" uniqKey="Xie E" first="En" last="Xie">En Xie</name></author><author><name sortKey="Chen, Song Hua" sort="Chen, Song Hua" uniqKey="Chen S" first="Song-Hua" last="Chen">Song-Hua Chen</name></author><author><name sortKey="Jiang, Zhi Qin" sort="Jiang, Zhi Qin" uniqKey="Jiang Z" first="Zhi-Qin" last="Jiang">Zhi-Qin Jiang</name></author><author><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name></author><author><name sortKey="Wang, Yuan" sort="Wang, Yuan" uniqKey="Wang Y" first="Yuan" last="Wang">Yuan Wang</name></author><author><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name></author><author><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia-Rui" last="Wu">Jia-Rui Wu</name></author></analytic><series><title level="j">Journal of molecular biology</title><idno type="ISSN">0022-2836</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Disulfides (metabolism)</term><term>Humans</term><term>Membrane Glycoproteins (metabolism)</term><term>Phylogeny</term><term>Proteomics</term><term>SARS Virus (chemistry)</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Sequence Analysis, Protein</term><term>Spike Glycoprotein, Coronavirus</term><term>Vero Cells</term><term>Viral Envelope Proteins (metabolism)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Animaux</term><term>Cellules Vero</term><term>Disulfures (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Humains</term><term>Phylogénie</term><term>Protéines de l'enveloppe virale (métabolisme)</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Protéomique</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Disulfides</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Disulfures</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Humans</term><term>Phylogeny</term><term>Proteomics</term><term>Sequence Analysis, Protein</term><term>Spike Glycoprotein, Coronavirus</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Animaux</term><term>Cellules Vero</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Phylogénie</term><term>Protéines virales</term><term>Protéomique</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15312778</PMID><DateCompleted><Year>2004</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-2836</ISSN><JournalIssue CitedMedium="Print"><Volume>341</Volume><Issue>1</Issue><PubDate><Year>2004</Year><Month>Jul</Month><Day>30</Day></PubDate></JournalIssue><Title>Journal of molecular biology</Title><ISOAbbreviation>J. Mol. Biol.</ISOAbbreviation></Journal><ArticleTitle>Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients.</ArticleTitle><Pagination><MedlinePgn>271-9</MedlinePgn></Pagination><Abstract><AbstractText>Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Rong</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Rui-Fu</ForeName><Initials>RF</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Mu-De</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Man-Rong</ForeName><Initials>MR</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>You-Hua</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Ruan</LastName><ForeName>Hong-Qiang</ForeName><Initials>HQ</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Xiao-Sheng</ForeName><Initials>XS</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Lv</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Hu</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lei</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xiao-Dong</ForeName><Initials>XD</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Ying</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>Yong-Yong</ForeName><Initials>YY</Initials></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Lei</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Er-Hei</ForeName><Initials>EH</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xiao-Yi</ForeName><Initials>XY</Initials></Author><Author ValidYN="Y"><LastName>Si</LastName><ForeName>Bin-Ying</ForeName><Initials>BY</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hong-Xia</ForeName><Initials>HX</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Cui-E</ForeName><Initials>CE</Initials></Author><Author ValidYN="Y"><LastName>Gan</LastName><ForeName>Yong-Hua</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yu-Chuan</ForeName><Initials>YC</Initials></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Ju-Tian</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Zuo</LastName><ForeName>Jiang-Ping</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Shi-Fang</ForeName><Initials>SF</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>En</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Song-Hua</ForeName><Initials>SH</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Zhi-Qin</ForeName><Initials>ZQ</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xi</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Pei</LastName><ForeName>Gang</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Bing</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jia-Rui</ForeName><Initials>JR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Mol Biol</MedlineTA><NlmUniqueID>2985088R</NlmUniqueID><ISSNLinking>0022-2836</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C487105">3a protein, severe acute respiratory syndrome coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004220">Disulfides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane 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