Nucleocapsid protein as early diagnostic marker for SARS.
Identifieur interne : 002A42 ( PubMed/Curation ); précédent : 002A41; suivant : 002A43Nucleocapsid protein as early diagnostic marker for SARS.
Auteurs : Xiao-Yan Che [République populaire de Chine] ; Wei Hao ; Yadi Wang ; Biao Di ; Kai Yin ; Yin-Chao Xu ; Chang-Sen Feng ; Zhuo-Yue Wan ; Vincent C C. Cheng ; Kwok-Yung YuenSource :
- Emerging infectious diseases [ 1080-6040 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- sang : Anticorps antiviraux, Protéines nucléocapside.
- Facteurs temps, Humains, Marqueurs biologiques.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral, Nucleocapsid Proteins.
- chemical : Biomarkers.
- diagnosis : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- Humans, Time Factors.
Abstract
Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6-10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.
DOI: 10.3201/eid1011.040516
PubMed: 15550204
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Cheng</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15550204</idno><idno type="pmid">15550204</idno><idno type="doi">10.3201/eid1011.040516</idno><idno type="wicri:Area/PubMed/Corpus">002A42</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A42</idno><idno type="wicri:Area/PubMed/Curation">002A42</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nucleocapsid protein as early diagnostic marker for SARS.</title><author><name sortKey="Che, Xiao Yan" sort="Che, Xiao Yan" uniqKey="Che X" first="Xiao-Yan" last="Che">Xiao-Yan Che</name><affiliation wicri:level="1"><nlm:affiliation>Center of Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou, People's Republic of China. linche@pub.guangzhou.gd.cn</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Hao, Wei" sort="Hao, Wei" uniqKey="Hao W" first="Wei" last="Hao">Wei Hao</name></author><author><name sortKey="Wang, Yadi" sort="Wang, Yadi" uniqKey="Wang Y" first="Yadi" last="Wang">Yadi Wang</name></author><author><name sortKey="Di, Biao" sort="Di, Biao" uniqKey="Di B" first="Biao" last="Di">Biao Di</name></author><author><name sortKey="Yin, Kai" sort="Yin, Kai" uniqKey="Yin K" first="Kai" last="Yin">Kai Yin</name></author><author><name sortKey="Xu, Yin Chao" sort="Xu, Yin Chao" uniqKey="Xu Y" first="Yin-Chao" last="Xu">Yin-Chao Xu</name></author><author><name sortKey="Feng, Chang Sen" sort="Feng, Chang Sen" uniqKey="Feng C" first="Chang-Sen" last="Feng">Chang-Sen Feng</name></author><author><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name></author><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C C" last="Cheng">Vincent C C. Cheng</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="ISSN">1080-6040</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (blood)</term><term>Biomarkers</term><term>Humans</term><term>Nucleocapsid Proteins (blood)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (sang)</term><term>Facteurs temps</term><term>Humains</term><term>Marqueurs biologiques</term><term>Protéines nucléocapside (sang)</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Nucleocapsid Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs temps</term><term>Humains</term><term>Marqueurs biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6-10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15550204</PMID><DateCompleted><Year>2005</Year><Month>08</Month><Day>04</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1080-6040</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>11</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Emerging infectious diseases</Title><ISOAbbreviation>Emerging Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Nucleocapsid protein as early diagnostic marker for SARS.</ArticleTitle><Pagination><MedlinePgn>1947-9</MedlinePgn></Pagination><Abstract><AbstractText>Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6-10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Che</LastName><ForeName>Xiao-Yan</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Center of Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou, People's Republic of China. linche@pub.guangzhou.gd.cn</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hao</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yadi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Di</LastName><ForeName>Biao</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Kai</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yin-Chao</ForeName><Initials>YC</Initials></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Chang-Sen</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Zhuo-Yue</ForeName><Initials>ZY</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Vincent C C</ForeName><Initials>VC</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Emerg Infect Dis</MedlineTA><NlmUniqueID>9508155</NlmUniqueID><ISSNLinking>1080-6040</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, 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