SrasV1, PubMed, Curation, bibRecord, 002661

Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus.

Identifieur interne : 002661 ( PubMed/Curation ); précédent : 002660; suivant : 002662

Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus.

Auteurs : Khalid Amine Timani [République populaire de Chine] ; Qingjiao Liao ; Linbai Ye ; Yingchun Zeng ; Jing Liu ; Yi Zheng ; Li Ye ; Xiaojun Yang ; Kong Lingbao ; Jingrong Gao ; Ying Zhu

Source :

Virus research [ 0168-1702 ] ; 2005.

RBID : pubmed:15992957

Descripteurs français

KwdFr :
- Animaux, Cellules Vero, Cytométrie en flux, Délétion de gène, Humains, Lapins, Microscopie confocale, Noyau de la cellule (métabolisme), Nucléole (métabolisme), Protéines nucléocapside (), Protéines nucléocapside (génétique), Protéines nucléocapside (métabolisme), Signaux de localisation nucléaire, Transfection, Virus du SRAS (génétique), Virus du SRAS (métabolisme), Virus du SRAS (pathogénicité).
MESH :
- génétique : Protéines nucléocapside, Virus du SRAS.
- métabolisme : Noyau de la cellule, Nucléole, Protéines nucléocapside, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- Animaux, Cellules Vero, Cytométrie en flux, Délétion de gène, Humains, Lapins, Microscopie confocale, Protéines nucléocapside, Signaux de localisation nucléaire, Transfection.

English descriptors

KwdEn :
- Animals, Cell Nucleolus (metabolism), Cell Nucleus (metabolism), Chlorocebus aethiops, Flow Cytometry, Gene Deletion, Humans, Microscopy, Confocal, Nuclear Localization Signals, Nucleocapsid Proteins (chemistry), Nucleocapsid Proteins (genetics), Nucleocapsid Proteins (metabolism), Rabbits, SARS Virus (genetics), SARS Virus (metabolism), SARS Virus (pathogenicity), Transfection, Vero Cells.
MESH :
- chemical , chemistry : Nucleocapsid Proteins.
- chemical , genetics : Nucleocapsid Proteins.
- chemical , metabolism : Nucleocapsid Proteins.
- chemical : Nuclear Localization Signals.
- genetics : SARS Virus.
- metabolism : Cell Nucleolus, Cell Nucleus, SARS Virus.
- pathogenicity : SARS Virus.
- Animals, Chlorocebus aethiops, Flow Cytometry, Gene Deletion, Humans, Microscopy, Confocal, Rabbits, Transfection, Vero Cells.

Abstract

A novel coronavirus (CoV) has recently been identified as the aetiological agent of severe acute respiratory syndrome (SARS). Nucleocapsid (N) proteins of the Coronaviridae family have no discernable homology, but they share a common nucleolar-cytoplasmic distribution pattern. There are three putative nuclear localization signal (NLS) motifs present in the N. To determine the role of these putative NLSs in the intracellular localization of the SARS-CoV N, we performed a confocal microscopy analysis using rabbit anti-N antisera. In this report, we show that the wild type N was distributed mainly in the cytoplasm. The N-terminal of the N, which contains the NLS1 (aa38-44), was localized to the nucleus. The C-terminus of the N, which contains both NLS2 (aa257-265) and NLS3 (aa369-390) was localized to the cytoplasm and the nucleolus. Results derived from analysis of various deletion mutations show that the region containing amino acids 226-289 is able to mediate nucleolar localization. The deletion of two hydrophobic regions that flanked the NLS3 recovered its activity and localized to the nucleus. Furthermore, deletion of leucine rich region (220-LALLLLDRLNRL) resulted in the accumulation of N to the cytoplasm and nucleolus, and when fusing this peptide to EGFP localization was cytoplasmic, suggesting that the N may act as a shuttle protein. Differences in nuclear/nucleolar localization properties of N from other members of coronavirus family suggest a unique function for N, which may play an important role in the pathogenesis of SARS.

DOI: 10.1016/j.virusres.2005.05.007
PubMed: 15992957

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A novel coronavirus (CoV) has recently been identified as the aetiological agent of severe acute respiratory syndrome (SARS). Nucleocapsid (N) proteins of the Coronaviridae family have no discernable homology, but they share a common nucleolar-cytoplasmic distribution pattern. There are three putative nuclear localization signal (NLS) motifs present in the N. To determine the role of these putative NLSs in the intracellular localization of the SARS-CoV N, we performed a confocal microscopy analysis using rabbit anti-N antisera. In this report, we show that the wild type N was distributed mainly in the cytoplasm. The N-terminal of the N, which contains the NLS1 (aa38-44), was localized to the nucleus. The C-terminus of the N, which contains both NLS2 (aa257-265) and NLS3 (aa369-390) was localized to the cytoplasm and the nucleolus. Results derived from analysis of various deletion mutations show that the region containing amino acids 226-289 is able to mediate nucleolar localization. The deletion of two hydrophobic regions that flanked the NLS3 recovered its activity and localized to the nucleus. Furthermore, deletion of leucine rich region (220-LALLLLDRLNRL) resulted in the accumulation of N to the cytoplasm and nucleolus, and when fusing this peptide to EGFP localization was cytoplasmic, suggesting that the N may act as a shuttle protein. Differences in nuclear/nucleolar localization properties of N from other members of coronavirus family suggest a unique function for N, which may play an important role in the pathogenesis of SARS.</div>
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<ReferenceList><Reference><Citation>J Gen Virol. 2005 Jan;86(Pt 1):211-215</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15604448</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Virol. 2004 Jul;73(3):332-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15170625</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Jun;78(11):5658-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15140963</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Virol. 2004 Jul;73(3):323-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15170624</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Exp Cell Res. 2000 Apr 10;256(1):213-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10739668</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2002 Apr;83(Pt 4):795-800</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11907328</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 1989 Aug 15;162(3):963-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2788417</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2003 Sep;95(1-2):13-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12921992</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proteomics. 2004 Feb;4(2):492-504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14760722</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 May 24;361(9371):1779-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781537</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2001 Apr 20;276(16):12675-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11278402</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Microbiol Mol Biol Rev. 2001 Dec;65(4):570-94, table of contents</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11729264</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 1988 Mar 11;52(5):655-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3125984</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 1991 Mar 7;1071(1):83-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2004116</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2000 Sep 25;69(2):109-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11018280</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Jan;78(1):76-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14671089</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Biochem Biophys. 1999 May 15;365(2):186-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10328811</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2003 Aug 29;331(5):991-1004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12927536</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2002 Feb 22;291(2):367-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11846414</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1996 Jul;70(7):4773-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8676505</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2002 May;76(10):5233-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11967337</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2004 Apr 2;316(2):476-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15020242</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2004 Oct 1;327(2):169-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15351204</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Oct;78(19):10410-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15367607</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 1999 Oct 25;263(2):313-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10544105</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2001 Jan;75(1):506-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11119619</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2004 Jul 9;319(4):1228-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15194498</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2004 May 14;317(4):1030-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15094372</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2004 Feb 20;314(4):931-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14751221</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Aug;78(15):7863-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15254158</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Jan;79(2):1164-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15613344</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Genomics. 1992 Dec;14(4):897-911</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1478671</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2003 Nov 28;311(4):870-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14623261</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 1999 Oct;64(1):1-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10500278</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem J. 2004 Oct 1;383(Pt 1):13-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15294014</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2004 Oct;105(2):121-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15351485</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2003 May 15;423(6937):240</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12748632</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Annu Rev Cell Dev Biol. 1995;11:155-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8689555</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 May;74(9):3975-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10756009</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 1981 Mar;53(Pt 1):67-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6268741</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2001 Oct;75(19):9345-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11533198</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2003 Sep;95(1-2):23-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12921993</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Virol. 2004 Aug;30(4):309-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15163419</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

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Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus.

Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus.

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